Syloid 244fp

Manufactured by Grace Bio-Labs

Syloid® 244FP is a synthetic amorphous silica product. It is a fine, white powder with a high surface area. The product is primarily used as a flow aid and absorbent in various applications.

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Lab products found in correlation

Polyplasdone xl, by Ashland (1 mentions) Opadry clear, by Colorcon (1 mentions) Aerosil, by Evonik (1 mentions)

2 protocols using syloid 244fp

Formulation and Quality Control of Curcumin-Boswellia Extract

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For the clinical study, the sunflower lecithin-based formulation of C. longa L. and B. serrata standardized extracts (500 mg) was prepared by Indena S.p.A., as oblong-shaped, film-coated tablets, corresponding to a content of 17.0–23.0% w/w of curcumin and 7.0–11.0% w/w of boswellia extracts, respectively by high performance liquid chromatography (HPLC) assay. The active ingredient is a solid dispersion containing the standardized association of curcumin extract (≥90% as total curcuminoids assessed by HPLC assay) and boswellia extract (≥65.0% of total triterpenic acids assessed by HPLC assay). The remaining food-grade components of the phytosome tablets are calcium carbonate E170 (95DC M; Dr Paul Lohman^®), polyvinylpolypyrrolidone E1202 (Polyplasdone^™ XL; Ashland), sodium croscarmellose E468 (Solutab^® A-IP; Blanver Farmoquimica LTDA), silicon dioxide E551 (Syloid^® 244FP; Grace), talc E553b (Mondo Minerals B.V.), magnesium stearate E470b (Ligafood^®; Peter Greven Nederland C.V.), and hydroxypropyl methylcellulose E463-based film-coating (Opadry^® Clear; Colorcon). Before releasing, the film-coated tablets containing the food-grade lecithin formulation were tested for appearance, average mass, uniformity of mass, HPLC-content of curcumin and boswellia extracts, disintegration time, and microbiological quality.

Giacosa A., Riva A., Petrangolini G., Allegrini P., Fazia T., Bernardinelli L., Gasparri C., Faliva M.A., Peroni G., Perna S, & Rondanelli M. (2020). Symptomatic uncomplicated diverticular disease management: an innovative food-grade formulation of Curcuma longa and Boswellia serrata extracts. Drugs in Context, 9, 2020-9-2.

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Pharmaceutical Formulation Development

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Feno was obtained from Sigma Aldrich. HPMC E5 (Methocel E5 LV) was procured from Dow chemicals. Syloid 244FP was procured from Grace and Aerosil was obtained from Evonik. The reagent like ethanol 190 proof was obtained from Sigma Aldrich.

Chaudhari S.P., Bhadiyadra M., & Dave R.H. (2020). Evaluating the effect of the porous and non-porous colloidal silicon dioxide as a stabilizer on amorphous solid dispersion. Journal of Drug Delivery and Therapeutics, 10(5), 255-263.

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