Prism 9 program

No power analysis was performed since we included all patients operated for BC during 2015 to 2016 in Region Halland. The χ²-test was used to compare categorical variables between groups. The Mann-Whitney test was used to compare continuous variables. Bivariate logistic regression analysis was performed and crude odds ratios and adjusted odds ratios were calculated for explanatory variables correlating with the dichotomous dependent variable adherence (adherent vs non-adherent). Adherence to ET over time was depicted with the Kaplan-Meier analysis and adherence between groups was compared using a 2-sided log-rank test (Mantel-Cox). Cases where termination of ET was due to progressive disease or death were censored. Statistical significance was set at P values less than .05. Mean value ± standard error of the mean (SEM) is given in the text or median (95% confidence interval) where indicated. IBM SPSS Statistics version 26 (IBM Corp, Armonk, NY, USA) and GraphPad Prism program 9.1.0 (GraphPad Software, Inc, San Diego, CA, USA) were used to analyse data.

The chi-square test was performed to compare categorical variables, and the Mann–Whitney U test was performed to compare continuous variables between the groups. Cox regression univariate and multivariate analyses were performed to identify factors predicting overall survival, and crude hazard ratios (CHRs) and adjusted hazard ratios (AHRs) with 95% confidence intervals (CIs) were estimated. Targeted therapy constituted a time-dependent variable in the Cox regression analyses. p-Values less than 0.05 were considered statistically significant. The mean value ± standard deviation (SD) is given in the text. Our statistical consultant, author U.S., controlled the statistics in the study. IBM SPSS Statistics version 26 (IBM Corp., Armonk, NY, USA) and GraphPad Prism program 9.1.0 (GraphPad Software, Inc., San Diego, CA, USA) were used to analyze the data.

To avoid confusion of analysis and focus on the role of PrP^C as a prognostic factor in HCC recurrence and overall survival, we applied the following standards in this study. First, we considered only when HCC recurrence was observed according to radiologic evidence. Second, only deaths from hepatic origin were considered for overall survival. We did not analyze non-hepatic origin deaths in determining cumulative survival rates. Based on the same criteria, multivariate analyses for recurrence and survival were performed using the Cox regression hazard model or logistic regression model.
Data are expressed as the mean ± SD or median (range). For statistical significance, Student’s t-test and χ² test were conducted for comparisons of variables between groups. The cumulative recurrence and survival were evaluated by the Kaplan–Meier method, and differences were determined by the log rank test. A multivariate analysis was carried out to identify independent predictors for recurrence and survival using a Cox regression hazard model or logistic regression model. A value of p < 0.05 was regarded as significant. All analyses were performed using SPSS 27.0 software (SPSS, Inc., Chicago, IL, USA) and GraphPad Prism 9 program (GraphPad software, San Diego, CA, USA).