Hydroxypropyl methylcellulose hpmc e5

Docetaxel (DOX) anhydrous (MWt = 807.9) was purchased from Knowshine (Shanghai) Pharmachemicals Inc. Hydroxypropyl methylcellulose (HPMC) E5 was purchased from Dow Chemical Co. (Midland, Michigan, USA). Sodium deoxycholate (SDC) was purchased from BDH Chemical Co. (Poole, England). Other chemicals were of reagent grade and were used as received. Undifferentiated/anaplastic thyroid cancer cell line (FRO) was kindly gifted from (King Faisal Specialist Hospital & Research Centre) KFSH & RC. The cells were cultured in humidified air with 5% CO2 at 37 °C in RPMI-1640 Medium with l-glutamine and sodium bicarbonate (R8758, Sigma Aldrich, St. Louis, MO, USA), and supplemented with 10% fetal bovine serum (FBS), and 1% penicillin-streptomycin, both from (Gibco).

Fenofibrate was purchased from Jiangsu Nhwa Pharmaceutical Co. (Xuzhou, China). Fenofibric acid and 4-chlorophenyl-4′-hydroxyphenyl methanone (internal standard) were acquired from Zhejiang Yidu Biotech Co. (Jiangshan, China). Commercial capsules of Lipilfen^® and Lipanthyl^® were purchased from Shanghai Ethypharm Pharmaceuticals Co. (Shanghai, China) and Laboratories Fournier (Dijon, France), respectively. Sucrose/starch nonpareil seeds (0.4–0.6 mm) were purchased from Hangzhou Gaocheng Biological Nutrient Technology Co. (Hangzhou, China). Aerosil^® 200, Eudragit^® RS PO, Eudragit^® E100 (Evonik, Essen, Germany), hydroxypropyl methylcellulose (HPMC) E5, ethyl cellulose (EC) 10 cPs (Dow Chemical Co., Midland, MI, USA), HPMC 6 cPs (Shin-Etsu Chemical Co., Tokyo, Japan), triethyl citrate (TEC [A Johnson Matthey, London, UK]), talc (passed through 200 mesh; Sichuan Serpentine Mineral Factory, Sichuan, China), polyethylene glycol (PEG) 4000, and lactose monohydrate (SLS, chemical grade) (Sinopharm Chemical Reagent Co., Shanghai, China) were used. Ethyl acetate, n-hexane, acetonitrile, and methanol were of chromatographic grade. All other reagents were of analytical grade or better.