Participants completed pre-randomization MRI at the Vanderbilt University Institute for Imaging Sciences on a research-dedicated 3.0 T Philips Achieva whole-body scanner (Philips Medical Systems, Best, the Netherlands) using body coil radiofrequency transmission and a 32-channel head coil for reception. Structural imaging included a whole-brain T1-weighted MPRAGE image with TR = 8.75 ms, TE = 4.6 ms, flip angle = 9°, and spatial resolution = 0.89 × 0.89 × 1.2 mm3 plus a FLAIR T2-weighted imaging conducted with TR = 10 000 ms, TE = 125 ms, TI = 2700 ms, flip angle = 90°, and spatial resolution = 0.7 × 0.7 × 2.0 mm3. Resting-state functional MRI was conducted with eyes open (TR = 2000 ms, echo time = 35 ms, flip angle = 77°, spatial resolution = 2.75 × 2.75 × 3.7 mm3, 35 axial slices). WMH volumes were measured on FLAIR images using the Lesion Segmentation Toolbox (Schmidt et al., 2012 (link)) as previously described (Gandelman et al., 2019 (link)).
Achieva whole body scanner
Manufactured by Philips
Sourced in Netherlands
The Achieva whole-body scanner is a medical imaging device manufactured by Philips. It is designed to perform full-body scans, capturing detailed images of the internal structures of the human body. The Achieva utilizes advanced magnetic resonance imaging (MRI) technology to generate these comprehensive scans.
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Lab products found in correlation
32 channel head coil, by Philips (9 mentions)
Sense head 8 channel head coil, by Philips (5 mentions)
8 channel sense head coil, by Philips (2 mentions)
8 channel head coil, by Philips (2 mentions)
Eight channel head coil, by Philips (1 mentions)
Sense head coil array, by Philips (1 mentions)
32 channel whole head coil, by Philips (1 mentions)
Trio tim 3.0 t scanner, by Siemens (1 mentions)
Matlab r2007b, by MathWorks (1 mentions)
32 channel receive head coil, by Philips (1 mentions)
8 channel sense radiofrequency head coil, by Philips (1 mentions)
Sense head coil, by Philips (1 mentions)
6 element sense receiver head coil, by Philips (1 mentions)
39 protocols using achieva whole body scanner
1
Multimodal Brain Imaging Protocol
2
High-Resolution 3D T1-Weighted MRI Acquisition
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Scans were acquired on a 3.0 Tesla Philips Achieva whole-body scanner (Philips Medical Systems, Best, The Netherlands) equipped with a transmit-receive body coil and a commercial eight-element sensitivity encoding (SENSE) head coil array. For each participant, a volumetric 3D T1-weighted fast field echo sequence was applied twice to obtain two scans each with a duration of 468 s and a spatial resolution of 0.94 × 0.94 × 1.0 mm3 (acquisition matrix: 256 × 256 pixels, 160 slices). Further imaging parameters were field of view = 240 × 240 mm2, echo time = 3.7 ms, repetition time = 8.06 ms, flip angle = 8° and sensitivity encoding factor = 2.1. The two scans were then coregistered and averaged to increase both the signal-to-noise as well as the contrast-to-noise ratio.
3
Multimodal MRI for Hippocampal Iron and Volume
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MRIs were collected at the University of Texas Southwestern Medical Center's Advanced Imaging Research Center on a single 3T Philips Achieva whole-body scanner (Philips Medical Systems, Andover, MA) equipped with a 32-channel head coil. Regional iron content was assessed with a T2*-weighted multiecho 3D gradient-recalled echo sequence (65 axial slices, 8 echo times 5.68 milliseconds +Δ 2.57 milliseconds, flip angle 15°, repetition time 37 milliseconds, field of view 256 mm2, 512 × 512 × 65 matrix, voxel size 0.5 × 0.5 × 2 mm3, total time 10:14 minutes). Regional medial temporal lobe (MTL) volumes were assessed from an ultrahigh-resolution T2/PD–weighted image of the MTL aligned along the longitudinal axis of the hippocampus (repetition time 3,500 milliseconds, echo time 44 milliseconds, field of view 215 × 215 mm, voxel size 0.42 × 0.42 × 2.00 mm3, 30 coronal slices, flip angle 120°, total time 6:46 minutes) and facilitated by collection of a T1-weighted high-resolution magnetization-prepared rapid acquisition with gradient echo sequence (repetition time 8.3 milliseconds, echo time 3.8 milliseconds, field of view 256 × 204 mm, voxel size 1 × 1 × 1 mm3, 160 sagittal slices, flip angle 12°, total time 3:57 minutes).
4
MRI Acquisition and Preprocessing in UPLOAD2 Study
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MRI data were acquired for eligible UPLOAD2 participants at the University of Florida using a 3.0 Tesla Philips Achieva whole body scanner with a 32-channel head coil and at the University of Alabama, Birmingham, using an eight-channel head coil. The head was secured via cushions positioned inside the head coil to minimize movement. T1-weighted (T1w) images were acquired using a high-resolution three-dimensional (3D) MP-RAGE sequence (repetition time = 7.0 ms, echo time = 3.2 ms/8°, 1 mm3 (link)
isotropic voxels) and used for analysis. Every acquired T1w image was preprocessed using FreeSurfer 7.1.0 (http://surfer.nmr.mgh.harvard.edu/ ), using the ‘recon-all’ function with default parameters for the general cortical reconstruction process. All calculated areas and their respective parameters were then matched to Destrieux atlas55 (link)
(Freesurfer’s aparc.2009s) for visualization and further analysis.
isotropic voxels) and used for analysis. Every acquired T1w image was preprocessed using FreeSurfer 7.1.0 (
(Freesurfer’s aparc.2009s) for visualization and further analysis.
5
Multimodal Neuroimaging for Assessing White Matter Hyperintensities
6
Multimodal Neuroimaging Protocol for Brain Assessment
7
Multimodal Neuroimaging Protocol: 3T MRI and Diffusion
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The magnetic resonance imaging (MRI) scans were acquired on a 3.0 T Philips Achieva whole-body scanner (Philips Medical System, Best, The Netherlands) equipped with a transmit-receive body coil and a commercial eight-element sensitivity encoding (SENSE) head coil array. Volumetric 3D T1-weighted gradient-echo sequence scans were obtained with a measured spatial resolution of 0.94 × 0.94 × 1 mm (acquisition matrix 256 x 256 pixel, 160 slices). Further imaging parameters were: field of view FOV = 240 × 240 mm, echo time TE = 3.7 ms, repetition time TR = 8.06 ms, flip angle = 8, and SENSE factor R = 2.1.
Diffusion-weighted spin echo-planar (EPI) sequence scans were obtained with a measured spatial resolution of 2.0 × 2.0 × 2.0 mm (acquisition matrix 112 × 112 pixels, 75 slices). Further imaging parameters were: field of view FOV = 224 × 224 mm, echo time TE = 55 ms, repetition time TR = 13.006 ms, flip angle FA = 90, and SENSE factor R = 2.1. Diffusion was measured in 64 non-collinear directions preceded by a non-diffusion-weighted volume (reference volume). The b-value was 1.000 s/mm2.
Diffusion-weighted spin echo-planar (EPI) sequence scans were obtained with a measured spatial resolution of 2.0 × 2.0 × 2.0 mm (acquisition matrix 112 × 112 pixels, 75 slices). Further imaging parameters were: field of view FOV = 224 × 224 mm, echo time TE = 55 ms, repetition time TR = 13.006 ms, flip angle FA = 90, and SENSE factor R = 2.1. Diffusion was measured in 64 non-collinear directions preceded by a non-diffusion-weighted volume (reference volume). The b-value was 1.000 s/mm2.
8
3T MRI Structural Brain Imaging
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Structural magnetic resonance images (MRI) were acquired on the same 3 Tesla Philips Achieva whole body scanner, with a standard 32‐channel whole‐head coil. T1‐weighted anatomical scans were obtained at each time point (TR = 9.8 ms, TE = 4.6 ms, flip angle = 8°, 140 slices, 0.875 mm × 0.875 mm × 1.2 mm, and FOV=224 × 177 × 168 mm). Scan time for this sequence was 4 min 56 s. There were no major scanner hardware or software upgrades during the data collection period. A radiologist reviewed all T1‐weighted scans; no anomalous findings were reported.
9
Resting-State fMRI Acquisition Protocol
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Imaging data were collected on a 3T, Phillips Achieva whole-body scanner, with an 8 channel Philips SENSE head coil (Philips Medical Systems). Functional images were obtained with a single-shot T2*—weighted echo planar imaging sequence. Imaging sequence consisting of 250 volumes with: repetition time (TR): 2000 ms; echo time (TE): 30 ms; 3mm isotropic voxels; field of view (FOV): 240 x 240 reconstructed into 80 x 80; flip angle 80°; 38 transverse slices with 0 gap and scanned in a default interleaved sequence. The slices where collected starting from the bottom of the brain, collecting all the odd number slices first (1, 3, 5…) and then collecting all the even number slices (2, 4, 6…). The total scan time was 8 minutes. Participants were instructed to close their eyes and to rest comfortably, without moving or falling asleep, during the functional scan. For the 3D scan, an anatomical image with: TR: 10462 ms; TE: 54 ms; 2mm isotropic voxels; FOV: 224 x 224; flip angle 90°: 60 transverse slices with 0 gap and scanned in the default interleaved sequence.
10
Multimodal Brain Imaging of Adult and Geriatric Cohorts
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The adult cohort was imaged on a research-dedicated whole-body Siemens 3.0 T Trio Tim scanner at Duke University Medical Center using an 8-channel head coil. Parallel imaging was employed with an acceleration factor of 2. Duplicate sagittal MPRAGE sequences were obtained using a repetition time (TR) of 2300 ms, echo time (TE) of 3.46 ms, a flip angle of 9°, a 256 × 256 matrix, FOV 240 mm, 160 slices with a 1.2 mm slice thickness for voxel size of 0.9 × 0.9 × 1.2 mm.
The geriatric cohort was imaged on a research-dedicated 3.0 T Philips Achieva whole-body scanner at Vanderbilt University Medical Center using a 32-channel head coil. The MPRAGE images were obtained using TR = 8.75 ms, TE = 4.6 ms, flip angle = 9°, and spatial resolution = 0.89; × 0.89 × 1.2 mm3 plus a FLAIR T2-weighted imaging conducted with TR = 10,000 ms, TE = 125 ms, TI = 2700 ms, flip angle = 90°, and spatial resolution = 0.7 × 0.7 × 2.0 mm3. FLAIR T2-weighted imaging was also conducted using TR = 10,000 ms, TE = 125 ms, TI = 2,700 ms, flip angle = 90°, and spatial resolution = 0.7 × 0.7 × 2.0 mm3.
The geriatric cohort was imaged on a research-dedicated 3.0 T Philips Achieva whole-body scanner at Vanderbilt University Medical Center using a 32-channel head coil. The MPRAGE images were obtained using TR = 8.75 ms, TE = 4.6 ms, flip angle = 9°, and spatial resolution = 0.89; × 0.89 × 1.2 mm3 plus a FLAIR T2-weighted imaging conducted with TR = 10,000 ms, TE = 125 ms, TI = 2700 ms, flip angle = 90°, and spatial resolution = 0.7 × 0.7 × 2.0 mm3. FLAIR T2-weighted imaging was also conducted using TR = 10,000 ms, TE = 125 ms, TI = 2,700 ms, flip angle = 90°, and spatial resolution = 0.7 × 0.7 × 2.0 mm3.
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