on Bruker 500 NMR spectrometers (Bruker, Billerica, MA, U.S.A.). Mass
spectra were recorded for CAD on a Bruker Daltonics microTOF-Q mass
spectrometer (Bruker, Billerica, MA, U.S.A.). In addition, the FTIR
spectra of CAD, CAD@ZIF-8, and CAD@ZIF-8-FA were recorded on a Thermo
Scientific Nicolet iS50 Fourier transform infrared spectrometer in
the wavenumber of 400–4000 cm–1. Particle
sizing was performed using dynamic light scattering with Zetasizer
Nano ZS (Malvern Instruments Ltd., U.K.). For each measurement, the
sample (1.0 mL) was put in a disposable polystyrene cuvette (SARSTEDT
AG & Co., Germany). The nanocarrier surface ζ-potential
was measured with Zetasizer Nano ZS by using disposable folded capillary
cells (DTS1070, Malvern, U.K.). Both the size and ζ-potential
were recorded as the average of three measurements. The structure
of the blank ZIF-8, CAD@ZIF-8, and CAD@ZIF-8-FA were evaluated by
transmission electron microscope (TEM; JEOL 1400 Plus, JEOL, U.S.A.)
at an acceleration voltage of 80 kV. The TEM samples were prepared
by using a tweezer to hold the carbon-coated copper grids (200 mesh;
Ted Pella, Inc., U.S.A.) and soaking them within the particle solution;
they were then removed and dried in the air prior to imaging.