Gap27

Manufactured by MedChemExpress

Gap27 is a chemical compound that functions as a gap junction inhibitor. It is used in laboratory research settings to study the role of gap junctions in various biological processes. Gap27 acts by blocking the formation and function of gap junctions, which are specialized cell-to-cell connections that facilitate the exchange of ions and small molecules between neighboring cells.

Automatically generated - may contain errors

Lab products found in correlation

Acacetin, by MedChemExpress (1 mentions) Lipopolysaccharides (lps), by Merck Group (1 mentions) Ferrostatin 1, by MedChemExpress (1 mentions)

2 protocols using gap27

Acacetin, LPS, and Gap27 Protocol

Check if the same lab product or an alternative is used in the 5 most similar protocols

Acacetin (MedChemExpress, molecular weight: 284.26 g/mol), LPS (Sigma, 055:B5, L2880), and Gap27 (MedChemExpress) were used in the experiments.

Ouyang Y., Rong Y., Wang Y., Guo Y., Shan L., Yu X., Li L., Si J., Li X, & Ma K. (2021). A Systematic Study of the Mechanism of Acacetin Against Sepsis Based on Network Pharmacology and Experimental Validation. Frontiers in Pharmacology, 12, 683645.

+ Open protocol

+ Expand

Neuroprotective Effects of Connexin43 Inhibition and GPX4 Activation

Check if the same lab product or an alternative is used in the 5 most similar protocols

Gap27 (a specific inhibitor of connexin43; 20 μg/kg; MedChemExpress) or Ferrostatin‐1 (an activator of GPX4; 125 μg/kg; MedChemExpress) was dissolved in physiological saline and then injected through the tail vein, 30 min prior to MCAO onset. The in vivo dose of Gap27 or Ferrostatin‐1 was according to a previous study of myocardial infarction¹⁷ and was tested in a preliminary study. Physiological saline was used in the control rats.

Qi Z., Yuan S., Liu K.J, & Ji X. (2022). Normobaric hyperoxia plays a neuroprotective role after cerebral ischemia by maintaining the redox homeostasis and the level of connexin43 in astrocytes. CNS Neuroscience & Therapeutics, 28(10), 1509-1518.

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!