Inveon preclinical ct scanner

Manufactured by Siemens

Sourced in United States

The Inveon Preclinical CT scanner is a compact and high-performance computed tomography (CT) imaging system designed for preclinical research. It provides high-resolution, three-dimensional imaging of small animals and samples. The system's core function is to capture detailed anatomical data using X-ray-based tomographic imaging techniques.

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Inveon micro PET/CT Preclinical Scanner Inveon Preclinical CT Inveon CT scanner Inveon scanner CT scanners Inveon Siemens scanners

4 protocols using inveon preclinical ct scanner

Micro-CT Analysis of Vossicle Implants

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The vossicle with the peak total bioluminescence flux measurement closest to the mean for their respective group (n = 1) was chosen for imaging by μCT (Inveon Preclinical CT scanner, Siemens Medical Solutions USA, Inc., Malvern, PA). This was performed to both visually represent the implant and to complement the radiographic and histologic findings. Images were acquired in ~441 projections over 360 degrees at 110 kVp, 150 MA, 1300 millisecond exposure, Bin 1, and a medium-high system magnification with an isotropic pixel width (resolution) of 9.7 μm. Image data was reconstructed using Cobra software(Exxim, Pleasanton, CA). Bone morphometric indices – trabecular volume/total volume (Tb.V/TV, %), trabecular number (Tb.N, 1/mm), trabecular thickness (Tb.Th, μm), trabecular separation (Tb.Sp, μm), and trabecular pattern factor (Tb.Pf) – were analyzed in the caudal-most vertebral body using 3D bone morphometry analysis software (Inveon Research Workplace 3D Image Software, Siemens PreClinical). Segmentation thresholds were kept constant for all treatment groups. Two-dimensional VD views were created (RATOC System Engineering Co, Tokyo, Japan).

Hildreth BE I.I.I., Williams M.C., Dembek K.A., Hernon K.M., Rosol T.J, & Toribio R.E. (2015). Engraftment and bone mass are enhanced by PTHrP 1-34 in ectopically transplanted vertebrae (vossicle model) and can be non-invasively monitored with bioluminescence and fluorescence imaging. Transgenic research, 24(6), 955-969.

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Microcomputed Tomography Analysis of Tibial Lesions

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The tibias were removed postmortem from mice injected intratibially and imaged using microcomputed tomography (µCT) (Siemens, Inveon Preclinical CT scanner, Siemens AG, Munich, Germany). Images were acquired in 400 projections over 360° at 100 kVp, 200 MA, 900 ms exposure, Bin 2, and a medium-high system magnification with a pixel width of 19 µm. Image data were reconstructed using Cobra software (Exxim, Pleasanton, CA) and analyzed using 3D analysis software (Inveon Research Workplace 3-Dimensional Image Software, Siemens PreClinical). Segmentation thresholds were kept constant for all bones. Five mice were euthanized at 3 weeks post-injection to characterize early lesions and other mice were euthanized at 6 weeks (late lesions).

Simmons J.K., Dirksen W.P., Hildreth BE I.I.I., Dorr C., Williams C., Thomas R., Breen M., Toribio R.E, & Rosol T.J. (2014). Canine Prostate Cancer Cell Line (Probasco) Produces Osteoblastic Metastases In Vivo. The Prostate, 74(13), 1251-1265.

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Quantitative Brain Volume Assessment Using Preclinical CT

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Mice were anesthetized with 3-5% isoflurane for 5 minutes in a chamber and then placed into the Inveon Preclinical CT scanner (Siemens). CT scans were performed with a field of view (FOV) of 5 x 8 cm and 520 projections. The reconstructed image resolutions were 512 x 512 x 768 with an isotropic resolution of 0.1 mm, utilizing the Feldkamp reconstruction algorithm, beam hardening correction, and Hounsfield units calibration. To analyze brain parenchymal volume, the Inveon's Research Workplace software was used. Singular images from axial, coronal, and sagittal slices were selected, ensuring consistent anatomical landmarks were used to obtain the largest brain volume per slice. For axial slices, the mandible bone was used as the landmark; for coronal slices, the tip of the nasal bone with the widest skull diameter was used; and in sagittal slices, the appearance and location of the C2 spinal vertebrae served as the landmark. Using the ROI (Region of Interest) function, brain parenchymal volume was calculated by highlighting the space within the skull for each slice. This analysis allowed for precise assessment of brain parenchymal volume and ensured consistent measurements across different image slices.

Tang T.Z., Zhao Y., Agarwal D., Tharzeen A., Patrikeev I., Zhang Y., DeJesus J., Bossmann S.H., Natarajan B., Motamedi M, & Szczesny B. (2024). Serum amyloid A and mitochondrial DNA in extracellular vesicles are novel markers for detecting traumatic brain injury in a mouse model. iScience, 27(2), 108932.

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Micro-CT Analysis of Murine Femoral Morphometry

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Femora were dissected from four day old mice and fixed for 24 hr in 4% paraformaldehyde, then stored in 70% ethanol. Micro-computed tomography (μCT) analysis was conducted on a Siemens Inveon Preclinical CT scanner (Siemens AG, Munich, Germany). Images were acquired in 400 projections over 360 degrees at 100 kVp, 200 MA, 1 second exposure, Bin 2, and a medium-high system magnification with a pixel width (resolution) of 19.4 μm. Image data was reconstructed using Cobra software (Exxim, Pleasanton CA) and analyzed using 3D bone morphometry analysis software (Inveon Research Workplace 3D Image Software, Siemens PreClinical).
Anatomical lengths of the femora were measured. The volume of interest (VOI) for analysis of the diaphysis was defined as the central 5% of the overall length of the bone and cropped. The distal metaphysis was defined as 12.5% of the overall length just proximal to the distal physis. The VOI for analysis of the distal metaphysis was then defined as the upper 40% of this region (5% of the overall length of the femur). Cortical bone morphometric indices were analyzed in both the diaphysis and distal metaphysis and trabecular bone morphometric indices were analyzed in the distal metaphysis. Segmentation thresholds were kept constant for all femora and bones were both cropped and analyzed in a blinded manner using predefined randomization tables.

Carey H.A., Bronisz A., Cabrera J., Hildreth BE I.I.I., Cuitiño M., Fu Q., Ahmad A., Toribio R.E., Ostrowski M.C, & Sharma S.M. (2016). Failure to Target RANKL Signaling Through p38-MAPK Results in Defective Osteoclastogenesis in the Microphthalmia Cloudy-eyed Mutant. Journal of cellular physiology, 231(3), 630-640.

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