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Menitorix

Manufactured by GlaxoSmithKline

Menitorix is a laboratory equipment product designed for the measurement and analysis of various biological and chemical samples. It is a versatile instrument that can be used in a wide range of research and testing applications.

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2 protocols using menitorix

1

Routine Infant Immunization Schedule

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All infants received routine immunisations according to the Australian National Immunisation Program: at birth: intramuscular HepB vaccine (H-B-Vax II Paediatric® (bioCSL)); at 6 weeks, 4 and 6 months of age: intramuscular combined diphtheria-tetanus-acellular pertussis (DTPa)-HepB-inactivated polio (IPV)-Haemophilus influenzae type b (Hib) vaccine (Infanrix® hexa (GlaxoSmithKline)), intramuscular 13-valent conjugate pneumococcal vaccine (PCV13) (conjugated to CRM197, a diphtheria toxin) (Prevenar13® (Wyeth)), and oral rotavirus vaccine (RotaTeq® (Merck)); at 12 months of age: subcutaneous measles-mumps-rubella (MMR) vaccine (Priorix® (GlaxoSmithKline)) or (M-M-R®II (Seqirus)) and intramuscular combined Hib and meningococcal C vaccine (conjugated to tetanus toxin) (Menitorix® (GlaxoSmithKline)). Approximately half of the infants were randomised to receive intradermal BCG-Denmark (Statens Serum Institute, Copenhagen) shortly after birth as part of the MIS BAIR. None of the infants received an influenza vaccine. Vaccine records were obtained from the National Australian Immunisation register and/or individual immunisation records.
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2

Hib-MenC Vaccine Antibody Response

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Antibody responses specific for Hib were studied as part of a single center, open-label clinical study in healthy adults aged 18-65 years, undertaken to generate a Hib reference serum for the UK’s National Institute for Biological Standards and Control (NIBSC). Written informed consent was obtained from the participants before enrollment. Ethical approval was obtained from the Oxfordshire Research Ethics Committee (OXREC Reference: 08/H0605/74). Volunteers received a Hib-MenC polysaccharide-protein conjugate vaccine (Menitorix®, GlaxoSmithKline), containing Hib polyribosyl ribitol phosphate (PRP, 5 μg) polysaccharide and meningococcal serogroup C polysaccharide (5 μg) individually conjugated to tetanus toxoid carrier protein (total 17.5 μg). Blood was taken from participants immediately prior to vaccination, and at 7 and 28 days after vaccination.
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