We created the B6 Albino MIP-luc ob/ob mice (ob/ob-luc) mouse by crossing CD-1MIP-luc mice (a kind gift from Dr. Graeme Bell (University of Chicago, IL)) and B6 Albino mice (provided by The Jackson Laboratory, Bar Harbor, Maine) to create B6 Albino MIP-luc mice using speed congenics. B6 ob/ob mice (provided by Taconic, Cranbury Township, New Jersey) were also crossed with B6 Albino mice to create B6 albino ob/ob mice. These B6 Albino MIP-luc (lean control) mice were crossed with B6 albino ob/ob mice to create the B6 Albino ob/ob MIP-luc mice (Figure S1 ). Both genders of mice homozygous for the B6 Albino and the ob/ob genes, and carriers of the MIP-luc genes were used for experimentation.
B6 albino mice
Manufactured by Jackson ImmunoResearch
B6 albino mice are a strain of laboratory mice commonly used in biomedical research. They have a white coat color due to a genetic mutation that affects pigmentation. These mice are widely used as a control or reference strain in various types of studies.
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5 protocols using b6 albino mice
1
Generation of B6 Albino ob/ob Mice
2
Compound 1a Induces Local and Systemic Anti-Cancer Effects
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Example 110
Compound 1a was tested for its anti-cancer activity in a GL261 brain orthotopic model. GL261 is a murine glioma cell line. Luciferase expressing GL261 mouse glioma cells (2×104 cells/mouse) were intra-cranially implanted into female 5-6 week-old B6 albino mice (Jackson Labs, Bar Harbor, Me.). Three to 4 days later, GL261 cells were implanted subcutaneously (106 cells/mouse) under the right forelimb area to allow development of a tumor mass for compound administration. Ten days after intra-cranial tumor cell implantation, compound (10 mg/kg) was administered intratumorally, a single time, into the sc tumor. The local anti-cancer effect of compound was measured through its effect on the sc tumor, while the compound's abscopal effect was assessed by the overall survival of treated mice compared with vehicle-treated control mice, based on the detrimental effect of the growing tumor mass in each mouse brain. Compound 1a showed both potent activity at local sc tumors and showed curative systemic activity in 5 of 8 treated animals (
3
Local and Systemic Anti-Cancer Effects
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Example 110
Compound 1a was tested for its anti-cancer activity in a GL261 brain orthotopic model. GL261 is a murine glioma cell line. Luciferase expressing GL261 mouse glioma cells (2×104 cells/mouse) were intra-cranially implanted into female 5-6 week-old B6 albino mice (Jackson Labs, Bar Harbor, Me.). Three to 4 days later, GL261 cells were implanted subcutaneously (106 cells/mouse) under the right forelimb area to allow development of a tumor mass for compound administration. Ten days after intra-cranial tumor cell implantation, compound (10 mg/kg) was administered intratumorally, a single time, into the sc tumor. The local anti-cancer effect of compound was measured through its effect on the sc tumor, while the compound's abscopal effect was assessed by the overall survival of treated mice compared with vehicle-treated control mice, based on the detrimental effect of the growing tumor mass in each mouse brain. Compound 1a showed both potent activity at local sc tumors and showed curative systemic activity in 5 of 8 treated animals (
4
Albino Mouse Husbandry Protocol
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All animal protocols were approved by the Institutional Animal Care and Use Committee of Rutgers University. B6(Cg)-Tyrc-2j/J or B6 albino mice were obtained from The Jackson Laboratory (Bar Harbor, ME). Mice were fed ad libitum standard chow and kept at 12 h light/12 h dark cycles.
5
Local and Systemic Anti-Cancer Effect of Compound 1a
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Example 110
Compound 1a was tested for its anti-cancer activity in a GL261 brain orthotopic model. GL261 is a murine glioma cell line. Luciferase expressing GL261 mouse glioma cells (2×104 cells/mouse) were intra-cranially implanted into female 5-6 week-old B6 albino mice (Jackson Labs, Bar Harbor, Me.). Three to 4 days later, GL261 cells were implanted subcutaneously (106 cells/mouse) under the right forelimb area to allow development of a tumor mass for compound administration. Ten days after intra-cranial tumor cell implantation, compound (10 mg/kg) was administered intratumorally, a single time, into the sc tumor. The local anti-cancer effect of compound was measured through its effect on the sc tumor, while the compound's abscopal effect was assessed by the overall survival of treated mice compared with vehicle-treated control mice, based on the detrimental effect of the growing tumor mass in each mouse brain. Compound 1a showed both potent activity at local sc tumors and showed curative systemic activity in 5 of 8 treated animals (
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