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Bsk805

Manufactured by Novartis
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The BSK805 is a laboratory equipment product. It is designed for use in research and testing applications. The core function of the BSK805 is to provide a controlled environment for conducting various experiments and analyses.

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Lab products found in correlation

Ruxolitinib, by Selleck Chemicals (2 mentions) Dexamethasone (dex), by Merck Group (1 mentions) Doxorubicin, by Merck Group (1 mentions) Cytarabine, by Merck Group (1 mentions) Chz868, by Novartis (1 mentions) Bbt594, by Novartis (1 mentions) Vincristine, by Cayman Chemical (1 mentions) Doxycycline, by Merck Group (1 mentions)

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NVP-BSK805 (5 citations)

2 protocols using bsk805

1

Evaluating Targeted Leukemia Therapies

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All continuous variables were compared using a two-sided t-test or one-way ANOVA, followed by Dunnett’s test or Tukey’s test for multiple comparisons, and error bars in all figures represent the SEM. Survival curves were compared using the log-rank test with GraphPad software. BSK805, BVB808, BBT594, and CHZ868 were synthesized by Novartis. Dexamethasone, cytarabine, and doxorubicin were purchased from Sigma-Aldrich. Vincristine was purchased from Cayman Chemical. Ruxolitinib was purchased from SelleckChem.
Wu S.C., Li L.S., Kopp N., Montero J., Chapuy B., Yoda A., Christie A.L., Liu H., Christodoulou A., van Bodegom D., van der Zwet J., Layer J.V., Tivey T., Lane A.A., Ryan J.A., Ng S.Y., DeAngelo D.J., Stone R.M., Steensma D., Wadleigh M., Harris M., Mandon E., Ebel N., Andraos R., Romanet V., Dölemeyer A., Sterker D., Zender M., Rodig S.J., Murakami M., Hofmann F., Kuo F., Eck M.J., Silverman L.B., Sallan S.E., Letai A., Baffert F., Vangrevelinghe E., Radimerski T., Gaul C, & Weinstock D.M. (2015). Activity of the type II JAK2 inhibitor CHZ868 in B-cell acute lymphoblastic leukemia. Cancer cell, 28(1), 29-41.
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2

Pharmacological Compound Preparation Methods

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BSK805 was obtained from Novartis and solubilized in DMSO for cell culture, or suspended in hydroxypropylmethylcellulose and tween 80. Ruxolitinib for cell culture was purchased from SelleckChem. Doxycycline was purchased from Sigma. Paclitaxel for injection was obtained from the Vanderbilt University Hospital Outpatient Pharmacy.
Balko J.M., Schwarz L.J., Cook R.S., Estrada M.V., Giltnane J.M., Sanders M.E., Sánchez V., Dean P.T., Wang K., Combs S.E., Hicks D., Pinto J.A., Landis M.D., Chang J.C., Doimi F.D., Gómez H., Rimm D.L., Yelensky R., Miller V.A., Stephens P.J, & Arteaga C.L. (2016). Triple negative breast cancers with amplification of JAK2 at the 9p24 loci demonstrate JAK2-specific dependence. Science translational medicine, 8(334), 334ra53.
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