Prism statistical program

Chi-squared test was performed to compare baseline clinical characteristics between patients in different groups. Survival curve was estimated by Kaplan–Meier analysis and the log-rank test was utilised to examine the significance of the differences in survival distributions between groups.
Data are presented as mean±s.d. The difference between the two groups was analysed using the unpaired Student's t-test, and Kruskal–Wallis analysis was used to test the differences between multiple groups. These statistical analyses were performed using the SPSS18 (SPSS, Chicago, IL, USA) and Prism statistical program (GraphPad, La Jolla, CA, USA). All statistical tests were two-sided, and P-value <0.05 was considered statistically significant.

For phenotype free survival, differences were calculated using the Mantel‐Cox log rank test method. Spearman's correlation was used to compute r and determine correlation between immunohistochemical stains. Reactive oxygen species (ROS) production and platelet aggregation were evaluated by t‐test. Changes in platelet binding under perfusion and platelet activation with flow cytometry were determined by two‐way analysis of variance. Statistical testing for the remaining readouts were calculated using the Mann‐Whitney rank‐sum test. All calculations were performed using the Prism statistical program, version 8 (GraphPad).