Mice were mobilized by G-CSF (6 days, 250 μg/kg, s.c.) or AMD3100 (5 mg/kg s.c.) in the absence or presence of refludan, a direct inhibitor of thrombin (5 mg/kg/day, divided in two doses; Bayer) or tranexamic acid, an inhibitor of plasminogen activation (20 mg/mice/day; Sigma Aldrich, MO, USA). Control mice were injected with vehicle, refludan, or tranexamic acid only. Six hours after the last G-CSF injection or 1 hour after AMD3100 injection, PB was obtained from the vena cava (with a 25-gauge needle and 1-mL syringe containing 250 U heparin).
Amd3100
Manufactured by Bayer
Sourced in United States
AMD3100 is a lab equipment product. It is a small-molecule compound that functions as a CXCR4 antagonist. The core function of AMD3100 is to inhibit the CXCR4 receptor, which plays a role in various biological processes.
Automatically generated - may contain errors
Lab products found in correlation
2 protocols using amd3100
1
Mobilization of Mice by G-CSF and AMD3100
2
Mobilizing Mice for Cell Transplantation
Check if the same lab product or an alternative is used in the 5 most similar protocols
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Mice were mobilized by G-CSF (6 days, 250 μg/kg, subcutaneously) or AMD3100 (5 mg/kg subcutaneous) in the absence or presence of refludan, a direct inhibitor of thrombin (5 mg/kg/day, divided in two doses; Bayer, Whippany, NJ, USA) or tranexamic acid, an inhibitor of plasminogen activation (20 mg/mice/day; Sigma-Aldrich, MO, USA). Control mice were injected with vehicle, refludan or tranexamic acid only. At 6 h after the last G-CSF injection or 1 h after AMD3100 injection, PB was obtained from the vena cava (with a 25-gauge needle and 1 ml syringe containing 250 U heparin).
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