The following drugs and chemicals were purchased from the chemicals supplier Sigma (now Millipore-Sigma) (St. Louis, MO, USA): L-3,4-dihydroxyphenylalanine methyl ester hydrochloride (L-dopa) (Sigma cat. # D1507 [For L-dopa IP injection, benserazide hydrochloride (Sigma cat. # B7283) is always injected concurrently to block peripheral dopa decarboxylase], 6-hydroxydopamine hydrochloride (6-OHDA) (Sigma cat. # H4381), dopamine hydrochloride (Sigma cat. # H8502), desipramine hydrochloride (Sigma cat. # D3900), and pargyline hydrochloride (Sigma cat. # P8013). Routine chemicals such sodium chloride (NaCl) for making 0.9% NaCl physiological saline were also purchased from Sigma (St. Louis, MO, USA). Buprenorphine, ketamine and xylazine were purchased from the animal healthcare supplier HenrySchien.com .
L 3 4 dihydroxyphenylalanine methyl ester hydrochloride l dopa
Manufactured by Merck Group
Sourced in United States
L-3,4-dihydroxyphenylalanine methyl ester hydrochloride (L-dopa) is a chemical compound used as a laboratory reagent. It serves as a precursor in the biosynthesis of the neurotransmitters dopamine, norepinephrine, and epinephrine.
Automatically generated - may contain errors
Lab products found in correlation
Benserazide hydrochloride, by Merck Group (2 mentions)
Dopamine hydrochloride, by Merck Group (1 mentions)
Pargyline hydrochloride, by Merck Group (1 mentions)
Desipramine hydrochloride, by Merck Group (1 mentions)
6 hydroxydopamine hydrochloride 6 ohda, by Merck Group (1 mentions)
L dopa, by Merck Group (1 mentions)
2 protocols using l 3 4 dihydroxyphenylalanine methyl ester hydrochloride l dopa
1
Neurotoxin-Induced Parkinson's Disease Model
2
Pharmacokinetics of L-DOPA and Retinoic Acid in Mice
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l-3,4-dihydroxyphenylalanine methyl ester hydrochloride (L-DOPA) and benserazide hydrochloride (peripheral L-DOPA decarboxylase inhibitor) were purchased from Sigma-Aldrich (St. Louis, MO). These drugs were dissolved in 0.9% saline and delivered to the mice via intraperitoneal (IP) injection. L-DOPA was always injected together with 5 mg/kg benserazide to inhibit peripheral DOPA decarboxylase. To avoid potential dopamine sensitization effects, each of these drugs was injected into a separate group of naïve mice. For dose-response experiments, each dose was also tested in a separate group of naïve mice. The injection was made between 9 AM and 4 PM. As described previously24 (link), all-trans-retinoic acid (RA) was dissolved in corn oil and mixed with regular mouse food pellets to a final concentration of 0.25 mg/g food. RA–supplemented diet was prepared fresh daily. The regular diet mixed with corn oil alone served as the control.
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