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Rag2 gammac mice

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Rag2−/− GammaC−/− mice are genetically modified mice that lack the Rag2 and GammaC genes. These mice have a severe combined immunodeficiency (SCID) phenotype, resulting in the absence of functional T and B cells. This mouse model is commonly used in research applications that require a severely immunocompromised host.

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Rag2−/− mice (48 citations)

4 protocols using rag2 gammac mice

1

Rag2-/- GammaC-/- Mouse Housing

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The Rag2−/− GammaC−/− mice were purchased from Jackson Laboratories. Animals were housed at room temperature (68–79°F) and 40–60% humidity.
Cakir B., Tanaka Y., Kiral F.R., Xiang Y., Dagliyan O., Wang J., Lee M., Greaney A.M., Yang W.S., duBoulay C., Kural M.H., Patterson B., Zhong M., Kim J., Bai Y., Min W., Niklason L.E., Patra P, & Park I.H. (2022). Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids. Nature Communications, 13, 430.
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2

Rag2−/− GammaC−/− Mice Protocol

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The Rag2−/− GammaC−/− mice were purchased from Jackson Laboratories. All animal experiments described in this study were approved by the Institutional Animal Care & Use Committee (IACUC) of Yale University.
Cakir B., Xiang Y., Tanaka Y., Kural M.H., Parent M., Kang Y.J., Chapeton K., Patterson B., Yuan Y., He C.S., Raredon M.S., Dengelegi J., Kim K.Y., Sun P., Zhong M., Lee S.H., Patra P., Hyder F., Niklason L.E., Lee S.H., Yoon Y.S, & Park I.H. (2019). Development of human brain organoids with functional vascular-like system. Nature methods, 16(11), 1169-1175.
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Rag2−/− GammaC−/− Mice Protocol

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The Rag2−/− GammaC−/− mice were purchased from Jackson Laboratories. All animal experiments described in this study were approved by the Institutional Animal Care & Use Committee (IACUC) of Yale University.
Cakir B., Xiang Y., Tanaka Y., Kural M.H., Parent M., Kang Y.J., Chapeton K., Patterson B., Yuan Y., He C.S., Raredon M.S., Dengelegi J., Kim K.Y., Sun P., Zhong M., Lee S.H., Patra P., Hyder F., Niklason L.E., Lee S.H., Yoon Y.S, & Park I.H. (2019). Development of human brain organoids with functional vascular-like system. Nature methods, 16(11), 1169-1175.
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4

Rag2-/- GammaC-/- Mouse Model

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The Rag2−/− GammaC−/− mice were purchased from Jackson Laboratories. All animal experiments described in this study were approved by the Institutional Animal Care & Use Committee (IACUC) of Yale University.
Kiral F.R., Cakir B., Tanaka Y., Kim J., Yang W., Wehbe F., Kang Y.J., Zhong M., Sancer G., Lee S.H., Xiang Y, & Park I.H. (2023). Generation of ventralized human thalamic organoids with thalamic reticular nucleus. Cell stem cell, 30(5), 677-688.e5.
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