Dogs were anaesthetized using butorphanol (0.2 mg/kg; Butomidor®, Richter Pharma, silures, Autria) in combination with medetomidine (5 μg/kg; Medetor®, CP-Pharma, Burgdorf, Germany) intravenously. Propofol (2–4 mg/kg to effect; Propovet®, Zoetis, Malakoff, France) intravenously was used for induction. Anesthesia was maintained with isoflurane (Iso-Vet®; Eurovet, Bladel, Netherlands). Dogs with intra-tracheal tubes were placed in ventral recumbency; the nasopharynx was manually obstructed. A 4-cm-long 12-Fr fenestrated catheter connected to a 60-mL syringe was introduced in the first third of the left nasal cavity. Twenty mL (20 ± 1 mL/kg) of sterile isotonic saline solution was then injected, with the ipsilateral nostril being completely manually obstructed to prevent leakage of the solution. The fluid was then directly aspirated in the syringe using manual suction while progressively removing the catheter from the nasal cavity (Video S1 ). The time of the procedure was recorded. Venous blood samples were obtained after the NALF procedure by jugular venipuncture using 5-mL plastic syringes and 21-G needles and placed immediately into 5-mL dry tubes.
Propovet
Manufactured by Zoetis
Sourced in France
Propovet is a veterinary anesthetic product used for the induction and maintenance of general anesthesia in dogs and cats. It contains the active ingredient propofol, a widely used intravenous anesthetic agent. Propovet provides rapid induction and smooth recovery from anesthesia.
Automatically generated - may contain errors
3 protocols using propovet
1
Nasal Lavage Fluid Collection in Dogs
2
Sheep Surgical Anesthesia and Monitoring
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On the day of surgery, pre-medication was performed by intravenous injection of a mixture of diazepam (Diazepam ® , TVM) and butorphanol (Torphasol ® , Axience). Anesthesia was induced by intravenous injection of propofol (Propovet ® , Zoetis). Each sheep was intubated, mechanically ventilated, and placed on isoflurane inhalant anesthetic (IsoFlo ® , Zoetis) for continued general anesthesia. A suitable electrolyte solution (Ringer lactate, Baxter) was administered via intravenous infusion during surgery. An anti-inflammatory drug (carprofen, Rimadyl ® , Zoetis, subcutaneous) and a prophylactic antibiotic treatment (amoxicillin, Duphamox LA ® , Zoetis, intramuscular) were administered via pre-operative injection. The surgical areas were clipped free of wool, scrubbed with povidone iodine (Vetedine savon ® , Vetoquinol), wiped with 70% isopropyl alcohol (Savetis), painted with povidone iodine solution (Vetedine solution ® , Vetoquinol), and draped. The sheep were placed in the supine position on a warmed pad. A rectal temperature probe and a rumen tube were inserted during surgery. Electrocardiogram (ECG), peripheral non-invasive arterial blood pressure, and oxygen saturation were monitored.
3
Nasal Swab Sampling in Dogs
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This study was approved by the ethical committee of the University of Liege (approval number: 1854) and all samples were obtained with informed and written owner consent.
Dogs were premedicated with butorphanol (0.2 mg/kg; Butomidor®, Richter Pharma) intravenously in combination with medetomidine (5 g/kg; Medetor®, CP-Pharma). Propofol (Propovet®, Zoetis) on demand was used for induction without intubation. Under general anesthesia the nostril was maintained open using a sterile speculum, and a sterile swab (Copan , FLOQSwabs TM , 553C, Brescia, Italy) was introduced through the speculum up to the distal third of the right nasal cavity (Figure 1). Three gentle complete circular movements were used to brush the mucosa before withdrawal of the swab through the speculum. The top of the swab was then cut, stored in a sterile cryotube and banked at -80°C until further analyses.
Dogs were premedicated with butorphanol (0.2 mg/kg; Butomidor®, Richter Pharma) intravenously in combination with medetomidine (5 g/kg; Medetor®, CP-Pharma). Propofol (Propovet®, Zoetis) on demand was used for induction without intubation. Under general anesthesia the nostril was maintained open using a sterile speculum, and a sterile swab (Copan , FLOQSwabs TM , 553C, Brescia, Italy) was introduced through the speculum up to the distal third of the right nasal cavity (Figure 1). Three gentle complete circular movements were used to brush the mucosa before withdrawal of the swab through the speculum. The top of the swab was then cut, stored in a sterile cryotube and banked at -80°C until further analyses.
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