Tamsulosin

Manufactured by Merck Group

Sourced in United States

Tamsulosin is a pharmaceutical compound used in the treatment of urinary tract disorders. It functions as an alpha-1 adrenergic receptor antagonist, which helps to relax the muscles in the prostate and bladder, facilitating the flow of urine.

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Lab products found in correlation

Close spelling variants of this product

Tamsulosin hydrochloride

3 protocols using tamsulosin

Pharmacological Agents for Urological Studies

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Krebs solution was obtained from Sigma Aldrich (St. Louis, MO, USA). Silodosin (Recordati, Milan, Italy), tamsulosin (Cayman, Ann Arbor, MI, USA), and naftopidil (Cayman) were procured and used. Silodosin and tamsulosin were dissolved in ethanol and naftopidil in methanol (Merck, Kenilworth, NJ, USA) and stored as stock solutions: Silodosin (1 mM), tamsulosin (400 nM), and naftopidil (200 µM) [15 (link)16 17 ].

Hong S.H., Jang E.B., Hwang H.J., Park S.Y., Moon H.S, & Yoon Y.E. (2022). Effect of α1D-adrenoceptor blocker for the reduction of ureteral contractions. Investigative and Clinical Urology, 64(1), 82-90.

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HuH-7 Cell Compound Screening

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Small-scale HuH-7^R-targeted quinazoline-derived small molecular compound screening was performed via IC₅₀ ranking based on MTT assays. HuH-7^R cells were seeded into 96-well plates and exposed to concentration gradients of prazosin (Sigma-Aldrich), cyproheptadine (Sigma-Aldrich), phentolamine (Sigma-Aldrich), doxazosin (Sigma-Aldrich), terazosin (Sigma-Aldrich), WB-4101 (Sigma-Aldrich), tamsulosin (Sigma-Aldrich), clozapine (Sigma-Aldrich), bunazosin (Angene Chemical), and ketanserin (Sigma-Aldrich) for 72 h. The IC₅₀ value of each compound was determined and ranked.

Chen C.T., Liao L.Z., Lu C.H., Huang Y.H., Lin Y.K., Lin J.H, & Chow L.P. (2020). Quantitative phosphoproteomic analysis identifies the potential therapeutic target EphA2 for overcoming sorafenib resistance in hepatocellular carcinoma cells. Experimental & Molecular Medicine, 52(3), 497-513.

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Pharmacological Interventions Protocol

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Quercetin, phenylephrine, tamsulosin, and cyclodextrin were purchased from Sigma‐Aldrich. The specific use of these drugs is specified in detail in each protocol above. Buprenorphine hydrochloride (Buprecare) and isoflurane (IsoFlo) were obtained from AST Farma, Oudewater, The Netherlands. Carprofen (Norocarp) was obtained from Norbrook Laboratories, Newry, UK.

Vrolijk M.F., van Essen H., Opperhuizen A., Bast A, & Janssen B.J. (2020). Haemodynamic effects of the flavonoid quercetin in rats revisited. British Journal of Pharmacology, 177(8), 1841-1852.

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