Cobas 8000 chemistry autoanalyzer

All clinical and laboratory variables included in this study were collected from records of electronic medical record (EMR) system in West China hospital. Demographic variables such as age and gender, injury mechanisms, vital signs on admission including systolic blood pressure, diastolic blood pressure, heart rate, body temperature and respiratory rate were collected in this study. Occurrence of anisocoria and Glasgow Coma Scale (GCS) on admission were also recorded. Variables of blood routine and blood biochemistry examination including serum cystatin C level were obtained by analyzing blood samples collected at admission. Serum concentrations of cystatin C was detected using the Cobas 8000 chemistry autoanalyzer (Roche Diagnostics, Switzerland). Anatomic injury types including epidural hematoma, subdural hematoma, intracerebral hematoma, subarachnoid hemorrhage, intraventricular hemorrhage and diffused axonal injury were recorded according to findings of CT scans. Red blood cell (RBC) transfusion, usage of drugs for reducing intracranial pressure and types of surgical operation were included. Outcome of this study was the occurrence of AKI in TBI patients during their hospitalization. AKI was diagnosed based on the KIDGO criteria from the second day after admission to discharge.