Injectomat tiva agilia

Manufactured by Fresenius

Sourced in Germany

The Injectomat TIVA Agilia is a syringe infusion pump designed for the administration of anesthetic and analgesic drugs during Total Intravenous Anesthesia (TIVA) procedures. The device is capable of precisely controlling the flow rate and volume of infused medications.

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5 protocols using injectomat tiva agilia

Propofol Pharmacokinetics in Healthy Volunteers

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Following approval by the Partners Human Research Committee (Boston, MA), 11 American Society of Anesthesiologists I healthy volunteers were studied in this randomized, crossover, nested protocol. All subjects provided written informed consent prior to participation. Subjects were recruited through a recurring broadcast e-mail advertisement to employees at Massachusetts General Hospital. Eligible subjects were 18-45 with a Body Mass Index of 18.5-28 kg/m² and with no history of dysphagia. Prior to enrollment, a preliminary history and physical was performed. All experiments were conducted at Massachusetts General Hospital in a research facility that was hospital-certified as an anesthetizing location. The study area was equipped with a standard anesthesia workstation with automated recordkeeping and resuscitation equipment.
Propofol was administered to target concentrations using a Fresenius target controlled infusion Pump (Injectomat TIVA Agilia, Fresenius Kabi, Brezins, France). Two board-certified anesthesiologists were present for the duration of each experiment, and one of them was assigned to monitor and care for the subject as his only responsibility. All subjects received standard anesthesia monitoring (electrocardiogram, pulse oximetry, capnography, and oscillometric blood pressure measurements).

D'Angelo O.M., Diaz-Gil D., Nunn D., Simons J.C., Gianatasio C., Mueller N., Meyer M.J., Pierce E., Rosow C, & Eikermann M. (2014). Anesthesia and increased hypercarbic drive impair the coordination between breathing and swallowing. Anesthesiology, 121(6), 1175-1183.

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Standardized Drug-Induced Sleep Endoscopy

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DISE was performed in a supine position in an operation room immediately before UPsT. Oxymetazoline-soaked pledgets were applied for the vasoconstriction of nasal mucosa before the procedure. Throughout the examination, a target-controlled infusion system (Fresenius Kabi Injectomat TIVA Agilia, Bad Homburg, German) was employed: the system had an initial propofol dose of 1.5 µg/mL that was increased at increments of 0.2 µg/mL to reach anesthesia of absent arousal to loud verbal stimulation and maintain the bispectral index (BIS) level at approximately 60–70.19 (link) When the required BIS level was achieved, a flexible endoscope was used to assess potential obstructions in the upper airway. The DISE procedure lasted at least 2 minutes long or two to three repeat cycles of snoring, hypoxia, obstruction with apnea and breakthrough with snoring again to ensure reproducible and reliable assessment. All DISE findings were scored by two experienced otolaryngologists on the velum, oropharyngeal lateral walls, tongue base, and epiglottis (VOTE) classification system.20 (link)

Chiu F.H., Chen C.Y., Lee J.C, & Hsu Y.S. (2021). Effect of Modified Uvulopalatopharyngoplasty without Tonsillectomy on Obstructive Sleep Apnea: Polysomnographic Outcome and Correlation with Drug-Induced Sleep Endoscopy. Nature and Science of Sleep, 13, 11-19.

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Anesthesia Management for Thoracoscopic Surgery

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All patients are fitted with a surgical mask before entering the operating room. The anesthesia provider ensures that the mask covers the nasal high-flow cannula from the time of induction of anesthesia onwards (Figure 1). The patient is then preoxygenated with nasal high-flow oxygen at an initial flow rate of 20 l/min (20 (link)). Pulse oximetry, electrocardiography, arterial blood pressure, and frontal bispectral index (BIS Quatro; Aspect Medical Systems, Norwood, MA, USA) are monitored continuously. A detector is placed in front of the nose or mouth to monitor end-tidal carbon dioxide. The patients are premedicated with 25–50 mcg of intravenous fentanyl, and then sedated with an intravenous target-controlled infusion of propofol (Injectomat® TIVA Agilia; Fresenius Kabi GmbH, Graz, Austria), as described elsewhere (17 (link)). The level of sedation is maintained at a BIS value of 40–60.
The patient is placed in a lateral decubitus position for thoracoscopic surgery. Fentanyl is injected incrementally to maintain a respiratory rate of < 20 breaths/min. The oxygen flow is temporarily suspended immediately before iatrogenic pneumothorax and resumed after confirmation of one-lung ventilation by the surgeon. Oxygen flow is limited to 20 l/min to maintain oxygen saturation above 90% throughout the procedure.

Wang M.L., Hung M.H., Hsu H.H., Cheng Y.J, & Chen J.S. (2022). Non-intubated Thoracoscopic Surgery to Minimize Contamination From Airway Secretions During the COVID-19 Pandemic. Frontiers in Surgery, 9, 818824.

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Fabrication of Charged PCL Nanofibers

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Polycaprolactone (Mw 80.000) and acetone (Barnes, Sydney, Australia) were used to make a polymer solution. The PCL solution was prepared by dissolving PCL pellets in acetone overnight. The rotating collector was based an aluminium tube with a gap feature and external covering [68 (link)]. A 10 mL syringe with 20 G needle was used to dispense the solution onto a grounded rotating collector. The needle tip was connected to a van der Graaf generator (Serrata, Dural, Australia) to charge the solution. Ejection rate was adjusted using a syringe pump (Injectomat Tiva Agilia, Fresenius Kabi AG, Bad Homburg, Germany). Each sample was produced using approximately 2 mL of PCL solution. Syringe temperature was controlled using a 35 W lamp.

Anindyajati A., Boughton P, & Ruys A.J. (2018). Modelling and Optimization of Polycaprolactone Ultrafine-Fibres Electrospinning Process Using Response Surface Methodology. Materials, 11(3), 441.

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Electrospinning of Polycaprolactone Scaffolds

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Polycaprolactone pellets (Mw 80.000) were dissolved in acetone (Barnes, Sydney, Australia) overnight to make an electrospinning solution with 10% w/v concentration. The electrospinning collector was a rotating aluminium mandrel featuring covered gaps [70 (link)]. Parameter setting for the process was flow rate, working distance, and mandrel rotation of 4.5 mL/h, of 12.5 cm, and 1500 RPM, respectively. PCL solution was dispensed from a 10 mL syringe with a 20 G needle onto the grounded collector. A van der Graaf generator (Serrata, Dural, Australia) was connected to the needle tip to generate an electrical charge into the polymer solution. A syringe pump (Injectomat Tiva Agilia, Fresenius Kabi AG, Bad Homburg, Germany) was used to adjust the flow rate.

Anindyajati A., Boughton P, & Ruys A.J. (2019). Mechanical and Cytocompatibility Evaluation of UHMWPE/PCL/Bioglass® Fibrous Composite for Acetabular Labrum Implant. Materials, 12(6), 916.

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