Terazosin hydrochloride

In electrophysiological experiments, l-noradrenaline bitartrate monohydrate (NA; Tokyo Chemical Industry, Tokyo, Japan), CNQX (Alomone Labs, Jerusalem, Israel), dl-AP-5 (AP-5; Tocris Bioscience, Bristol, UK), terazosin hydrochloride (Sigma, St. Louis, MO, USA), atipamezole hydrochloride (Wako, Osaka, Japan), timolol maleate (Sigma), and phenylephrine hydrochloride (Wako) were dissolved in distilled water. Picrotoxin (Sigma) was dissolved in dimethyl sulfoxide. These drug solutions were diluted with standard Ringer’s solution before use. Kynurenic acid hydrate (KYNA; Tokyo Chemical Industry) was dissolved in standard Ringer’s solution. In behavioral experiments, Picrotoxin, NA, and terazosin (Tocris) were dissolved in phosphate-buffered saline (PBS). Picrotoxin injection into the cortex has been reported to elicit seizures^{29 (link)}. The doses of drugs were chosen based on the previous studies^{26 (link),30 (link)–32 (link)}.

Leflunomide, teriflunomide, tolvaptan and BTP2 were purchased from Tocris Bioscience (Bristol, UK). Omeprazole, lansoprazole, rufinamide, prazosin hydrochloride, terazosin hydrochloride, flutamide, roflumilast and propidium iodide were purchased from Sigma-Aldrich (Dorset, UK). Conivaptan hydrochloride was purchased from Selleckchem (distributed by Stratech, Suffolk, UK) and OAG was purchased from Cayman Chemicals (distributed by Cambridge Bioscience, Cambridge, UK). All molecules were of ≥98% purity certified by the vendors.