6510 q tof spectrometer

Unless otherwise specified, all commercially available reagents were used as received. Analytical thin layer chromatography (TLC) was carried out on silica gel 60 F254 plates with visualization using ultraviolet light or potassium permanganate dip. Column chromatography was carried out using silica gel 60 (70-200 µm). 1 H and 13 C NMR spectra were recorded on 300 or 500 MHz instruments. The chemical shifts are given in parts per million ( ppm) on the delta scale. The solvent peak was used as the reference value: for 1 H NMR, CHCl 3 = 7.26 ppm; for 13 C NMR, CHCl 3 = 77.16 ppm. Infrared spectra were recorded neat. ESI-HRMS were carried out on an Agilent 6510 Q-TOF spectrometer at the CRMPO (Centre Regional de Mesures Physiques de l'Ouest), University of Rennes.

NMR spectra were recorded in CDCl 3 on Bruker AM-300 (300 MHz) spectrometer at ambient temperature. Chemical shifts are reported in ppm relative to TMS as internal standard and coupling constants are reported in Hz. FTIR spectra were recorded on a Nicolet FT-IR 400 spectrometer in KBr or as neat. Optical rotations were measured on an Perkin-Elmer 141 polarimeter by using a 2 mL cell with a path length of 1 dm with CHCl 3 or CDCl 3 as solvent. Low resolution mass spectra were obtained on VG 70-70H or LC/MSD trap SL spectrometer operating at 70 eV using direct inlet system. High resolution mass spectra (HRMS) were recorded on an Agilent Technologies 6510 Q-TOF spectrometer. Technical-grade EtOAc and hexanes used for column chromatography were distilled before use. All the reagents and solvents were of reagent grade and used without further purification unless otherwise stated.