Methoxy poly ethylene glycol thiol

Manufactured by Laysan Bio

Sourced in United States

Methoxy-poly(ethylene-glycol)-thiol is a chemical compound used in various laboratory applications. It serves as a versatile building block for the preparation of functionalized polymers and conjugates. The product's core function is to provide a reactive thiol group for chemical modifications and conjugation reactions.

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Lab products found in correlation

Peg sh, by Laysan Bio (1 mentions) Citric acid monohydrate, by Merck Group (1 mentions) Hexane, by Merck Group (1 mentions) Dimethyl sulfoxide (dmso), by Merck Group (1 mentions) Dimethylformamide, by Merck Group (1 mentions) Tetrahydrofuran, by Merck Group (1 mentions) 1 6 hexanediol diacrylate, by Thermo Fisher Scientific (1 mentions) Disodium phosphate, by Merck Group (1 mentions) Decylamine, by Merck Group (1 mentions) 1 3 aminopropyl 4 methylpiperazine e7, by Thermo Fisher Scientific (1 mentions) 1 4 butanediol diacrylate, by Thermo Fisher Scientific (1 mentions)

Close spelling variants of this product

Poly(ethylene glycol) (2 citations) Methoxy-poly(ethylene glycol)-thiol (mPEG-SH, (2 citations)

2 protocols using methoxy poly ethylene glycol thiol

Multifunctional Theranostic Nanoparticles

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Methoxy poly(ethylene glycol)-b-poly(lactic-co-glycolic acid) (Mw ~5000:20000 Da) (PLGA-PEG), poly(lactic-co-glycolic)-b-poly(ethylene glycol)-maleimide (Mw ~20000:5000 Da) (PLGA-PEG-MAL), methoxy poly(ethylene glycol)-b-poly((D,L) lactic acid) (MW ~5000:16000 Da) (PLA-PEG) and maleimide-poly(ethylene glycol)-b-poly(D,L-lactide) (MW ~5000:16000 Da) were purchased from Polyscitech Inc. Methoxy-poly(ethylene-glycol)-thiol (Mw~2000 Da and Mw~5000 Da) (PEG-SH) were purchased from Laysan Bio Inc, while FITC-Poly(ethylene glycol)-thiol (Mw~2000 Da) was obtained from Nanocs. Mouse breast cancer cell line (4T1) was purchased from ATCC Inc. DiD oil (DilC18(5) oil) was a product of Life Technologies. Maleimide quantification assay was a product of Abcam®. Additional salts, solvents and buffers were purchased from Fisher Scientific. Antibodies for flow cytometry analysis were all purchased from Biolegend.

Zhou H., Fan Z., Li P.Y., Deng J., Arhontoulis D.C., Li C.Y., Bowne W.B, & Cheng H. (2018). Dense and Dynamic Polyethylene Glycol Shells Cloak Nanoparticles from Uptake by Liver Endothelial Cells for Long Blood Circulation. ACS nano, 12(10), 10130-10141.

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Tailored Biomaterial Synthesis Protocol

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1,4-Butanediol diacrylate (B4), 1,6-hexanediol diacrylate (B6), 1-(3-aminopropyl)-4-methylpiperazine (E7) (Alfa Aesar), octylamine (S8m), decylamine (S10m), acetone, dimethyl sulfoxide (DMSO), dimethylformamide (DMF), tetrahydrofuran (THF), hexane, citric acid monohydrate, disodium phosphate (Sigma-Aldrich, St. Louis, MO, USA), methoxy poly(ethylene glycol) thiol (2 kDa and 800 Da) (Laysan Bio, Inc.), and Verteporfin (VP (US Pharmacopeial Convention, Inc.) were purchased and used as received.

Shamul J.G., Shah S.R., Kim J., Schiapparelli P., Vazquez-Ramos C.A., Lee B.J., Patel K.K., Shin A., Quinones-Hinojosa A, & Green J.J. (2019). Verteporfin-Loaded Anisotropic Poly(Beta-Amino Ester)-Based Micelles Demonstrate Brain Cancer-Selective Cytotoxicity and Enhanced Pharmacokinetics. International Journal of Nanomedicine, 14, 10047-10060.

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