Fecl2 4h2o

The materials were used to synthesize MNPs:
FeCl₃·6H₂O, ≥99%; FeCl₂·4H₂O, ≥99%; MnCl₂·4H₂O, ≥99%; and NaOH, ≥99% purchased from Sigma-Aldrich.
All the chemicals were used without further purification and are water
soluble.

Green (D512S, ZnS:Cu) and orange (D611S, ZnS:Cu,Mn) microparticles were purchased from Shanghai KPT Co. Poly(vinylidene fluoride-cotrifluoroethylene-co-chlorofluoroethylene) [P(VDF-TrFE-CFE)] was purchased from Piezotech, Inc. Short MWNTs (US4365) grown by chemical vapor deposition and purified to over 95 wt% were manufactured at US Research Nanomaterials, Inc., Houston, USA. FeCl₃·6H₂O and FeCl₂·4H₂O were purchased from Sigma-Aldrich. NaOH was purchased from Daejung Co. N-hexadecane was purchased from Alfa Aesar. All other chemicals were purchased from Sigma-Aldrich and used as received. VHB 4905 and 4910 were purchased from 3 M and used as received.

CP hydrochloride was purchased from Sobhan Oncology Co., Tehran, Iran. β-CD was purchased from Walker Chemie, Munich, Germany, o-Phenylenediamine and potassium dihydrogen orthophosphate, dimethylformamide (DMF), ammonium hydroxide (25%) and sodium hydroxide flakes were purchased from Merck, Darmstat, Germany. FeCl₂- 4H₂O, FeCl₃-6H₂O, and sodium alginate were purchased from Sigma-Aldrich, Louis, MO, USA, and used without further purification except when mentioned specifically. Dulbecco’s modified eagle’s medium F12 (DMEM), fetal bovine serum (FBS), penicillin–streptomycin (100 μg/mL), phosphate-buffered saline (PBS), MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide), and dimethyl sulphoxide (DMSO) were purchased from the Sigma Aldrich Company, Mo, USA.

TiCl₄ (97%), FeCl₂·4H₂O (98%), FeCl₃·6H₂O (97%) NH₃·H₂O (25%), PEG400 (p.a.), ammonium oxalate (99%), silver nitrate (>99%), tert-butyl alcohol (99%) benzoquinone (p.a.) and metronidazole (>99%) were purchased from Sigma-Aldrich (USA). The used reagents had an analytical grade. Whereas the water used in all experiments was deionized.

For the synthesis of the core-shell nanoparticles, iron oxide nanoparticles were firstly synthesized within the droplets of the reactor, as previously described^{24 (link),34 (link)}. Briefly, through the first two fused silica capillaries of the reactor, two aqueous solutions were injected at a flow rate of 10 µL/min. The first solution was 0.06 M of FeCl₃·6H₂O (Alfa Aesar, USA) and 0.03 M of FeCl₂∙4H₂O (Sigma-Aldrich, USA) dissolved in DI water, and the second solution was 4 M ammonia (Alfa Aesar, USA). As a continuous phase mineral oil (M5904, Sigma-Aldrich USA) with 0.075 vol % Triton X-100 (Samchun Chemical, Korea) and 1.75 vol % Abil EM 90 (Evonik Industrial, Germany) was used, the flowrate injected through the central Tygon tubing was 10 µL/min. For the synthesis of the gold shell around the iron cores, a gold precursor solution was injected into the existing droplets through the single capillaries at 100, 130, and 160 cm. The gold precursor solution consisted of 0.03 M HAuCl₄ (Sigma-Aldrich USA) dissolved in DI water. For all three injections, the same flowrate was used and flowrate was determined by a self-optimizing algorithm based on the transmission of the droplets and two initial guesses for the flowrate. To quench the reaction, core-shell nanoparticles were collected in a vial filled with water, once they left the capillary droplet reactor.