Chemicals such as 1-amino-propan-2-ol, 2,2′-azobisisobutyronitrile (AIBN), methacryloyl chloride, 6-amino hexanoic acid, tert-butoxycarbonyl hydrazide, N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC), carbon disulfide, ethanethiol, sodium hydride (60% dispersion in mineral oil), 5-hydroxy-2-pentanone, 4,6-trinitrobenzene-1-sulfonic acid (TNBSA), pentafluorophenol, 4-(dimethylamino)pyridine (DMAP), tert-butanol, N,N-dimethylacetamide (DMA), dichloromethane (DCM), dimethyl sulfoxide (DMSO), and 4-oxo-2,2,6,6-tetramethyl-1-piperidinyloxy, free radical (4-oxo-TEMP) were obtained from Merck (Czech Republic). Pyropheophorbide-a was purchased from Frontier Scientific® (USA), 2,2′-azobis(4-methoxy-2,4-dimethylvaleronitrile) (V-70) from Wako Chemicals (Germany), and N-(3-tert-butoxycarbonyl-aminopropyl)methacrylamide (APMA-Boc) from Polysciences, Inc., (USA). All of the other chemicals and solvents were of analytical grade. The solvents for the nuclear magnetic resonance (NMR) characterization of DMSO-d6 (99.80 atom% D) and CD3OD (99.80 atom% D) were obtained from VWR Chemicals (Belgium).
2 2 azobis 4 methoxy 2 4 dimethylvaleronitrile v 70
Manufactured by Fujifilm
Sourced in Germany, United States
2,2′-azobis(4-methoxy-2,4-dimethylvaleronitrile) (V-70) is a chemical compound used as a free radical initiator in various chemical processes. It is a solid, crystalline substance that decomposes to generate free radicals at a specific temperature range. The compound's core function is to initiate and promote free radical reactions in chemical synthesis, polymerization, and other applications where controlled free radical generation is required.
Automatically generated - may contain errors
Lab products found in correlation
Methacryloyl chloride, by Merck Group (2 mentions)
N 3 tert butoxycarbonyl aminopropyl methacrylamide apma boc, by Polysciences (2 mentions)
N n dimethylacetamide, by Merck Group (2 mentions)
2 2 azobisisobutyronitrile, by Merck Group (2 mentions)
Dmso d6, by Avantor (1 mentions)
Cd3od, by Avantor (1 mentions)
4 dimethylaminopyridine, by Merck Group (1 mentions)
N ethyl n 3 dimethylaminopropyl carbodiimide hydrochloride, by Merck Group (1 mentions)
Ethanethiol, by Merck Group (1 mentions)
Carbon disulfide, by Merck Group (1 mentions)
Tert butanol, by Merck Group (1 mentions)
Dichloromethane, by Merck Group (1 mentions)
Sodium hydride, by Merck Group (1 mentions)
Protein assay kit, by Bio-Rad (1 mentions)
Uv 2550, by Shimadzu (1 mentions)
Hplc grade methanol, by Avantor (1 mentions)
Glycerol monomethacrylate, by Polysciences (1 mentions)
Tfv d6, by LGC (1 mentions)
Dichloromethane, by Avantor (1 mentions)
Isopropanol, by Avantor (1 mentions)
6 protocols using 2 2 azobis 4 methoxy 2 4 dimethylvaleronitrile v 70
1
Synthesis of Photosensitizer Conjugates
2
Measuring LDL Oxidative Susceptibility
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LDL oxidative susceptibility was measured using a conventional method (Kurihara et al., 2003) (link). Blood samples were collected into tubes containing ethylenediaminetetraacetic acid (EDTA) from subjects in the morning after an overnight fast. Plasma samples were then stored frozen at –80°C until the LDL oxidation assay. After a plasma sample was adjusted to a specific gravity with KBr (Wako Pure Chemical, Japan), the LDL fraction was subsequently obtained by ultracentrifugation at 100 000 rpm for 40 min. The protein concentration in the LDL fraction was determined using a protein assay kit (Bio-Rad, USA) and adjusted to 70 μg/mL with phosphate-buffered saline. 2,2’-Azobis(4-methoxy-2.4-dimethyl valeronitrile) (V70, Wako Pure Chemical, Japan) was added to a final concentration of 400 μM, followed by incubation at 37°C. Absorbance at 234 nm was measured using a spectrophotometer (UV-2550, Shimadzu, Japan), and the lag time until the start of conjugated diene formation was measured.
3
Synthesis and Characterization of Tenofovir Alafenamide Polymer Conjugates
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Materials were purchased from Sigma-Aldrich unless otherwise specified. All solvents were Fisher HPLC grade. Chain transfer agents, 4-(((2-carboxyethyl)thiocarbonothioyl)thio)-4cyanopentanoic acid (CCC) and 4-cyano-4-((ethylsufanylthiocarbonyl)-sulfanyl)pentanoic acid (ECT) were purchased from Boron Molecular and OMM Scientific (Texas, USA), respectively.
Glycerol monomethacrylate was purchased from Polysciences and purified using basic alumina before polymerization. 2,2'-Azobis(4-methoxy-2,4-dimethylvaleronitrile) (V-70) was purchased from FUJIFILM Wako Pure Chemical Corporation, USA and used without further purification.
Fasudil hydrochloride was purchased from eNovation Chemicals (Green Brook, NJ, USA). Spectra/Por regenerated cellulose dialysis membranes were purchased from Spectrum Laboratories (Houston, TX, USA). Rhodamine B methacrylate (RhMA) was synthesized as described previously. [43] (link) Tenofovir alafenamide (TAF) fumarate (1:1 salt) was obtained from MedKoo Biosciences, Inc. Analytical standards: tenofovir (TFV) and tenofovir diphosphate (TFV-DP) were obtained from Cayman Chemical and Santa Cruz Biotech, respectively. Isotopic internal standards: TAF-d5 fumarate, TFV-d6 and TFV-DP 13 C5 were obtained from Toronto Research Chemicals and Moravek, respectively. HPLC grade methanol and water were purchased from VWR international Ltd.
Glycerol monomethacrylate was purchased from Polysciences and purified using basic alumina before polymerization. 2,2'-Azobis(4-methoxy-2,4-dimethylvaleronitrile) (V-70) was purchased from FUJIFILM Wako Pure Chemical Corporation, USA and used without further purification.
Fasudil hydrochloride was purchased from eNovation Chemicals (Green Brook, NJ, USA). Spectra/Por regenerated cellulose dialysis membranes were purchased from Spectrum Laboratories (Houston, TX, USA). Rhodamine B methacrylate (RhMA) was synthesized as described previously. [43] (link) Tenofovir alafenamide (TAF) fumarate (1:1 salt) was obtained from MedKoo Biosciences, Inc. Analytical standards: tenofovir (TFV) and tenofovir diphosphate (TFV-DP) were obtained from Cayman Chemical and Santa Cruz Biotech, respectively. Isotopic internal standards: TAF-d5 fumarate, TFV-d6 and TFV-DP 13 C5 were obtained from Toronto Research Chemicals and Moravek, respectively. HPLC grade methanol and water were purchased from VWR international Ltd.
4
Synthesis and Characterization of Multifunctional Polymers
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The chemicals used in this study were bought from the following suppliers and unless otherwise stated were used without further purification: PEG (average Mw = 3400) was purchased from Sigma Aldrich (Steinheim, Germany, now Merck KGaA). Acryloylchloride was purchased from Merck KGaA (Darmstadt, Germany). 4-Acryloylmorpholine (purity 97%), Iodmethane (purity 99%), and Triethylamine (purity 99%) were purchased from Acros Organics (Schwerte, Germany, now Thermo Fisher Scientific Inc.). MethAcryloylchloride (purity 97%) was purchased from Alfa Aesar (Landau, Germany, now Thermo Fisher Scientific Inc.). Cystamine dihydrochloride (purity > 97%) was purchased from TCI (Tokyo, Japan). The initiator 2,2′-Azobis(4-methoxy-2,4-dimethylvaleronitrile) (V-70) was purchased from FUJIFILM Wako Chemicals Europe GmbH (Neuss, Germany). Dithiothreitol (purity 98%) was purchased from abcr GmbH (Karlsruhe, Germany). All solvents used were either HPLC-grade or technical grade. In the case of technical grade solvents, all solvents were distilled prior to use. Isopropanol, Dichloromethane, and Tetrahydrofuran were purchased from VWR (Bridgeport, NJ 08014, PA, USA). Dimethylsulfoxide (purity 99%) was purchased from Grüssing GmbH (Filsum, Germany).
5
Synthesis of Functional Polymer Precursors
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3-Aminopropanoic acid, 4,4′-azobis(4-cyanopentanoic acid) (ACVA), 2,2′-azobis(2-methylpropionitrile) (AIBN), N,N'-dicyclohexylcarbodiimide (DCC), 4-dimethylaminopyridine (DMAP), methacryloyl chloride, 2-methacryloyloxyethyl phosphorylcholine (MPC), thiazolidine-2-thione (TT) and triethylamine (TEA) were purchased from TCI Europe, Belgium. Ammonium hydroxide, 4-cyano-4-(phenylcarbonothioylthio)pentanoic acid (CPP), 2-cyano-2-propyl benzodithioate (CPB), deferoxamine methanesulphonate salt (DFA), iron(III) chloride hexahydrate, iron(II) chloride tetrahydrate and sodium bicarbonate were purchased from Sigma-Aldrich, Czech Republic. 2,2'-Azobis(4-methoxy-2,4-dimethylvaleronitrile) (V-70) was from FUJIFILM Wako Chemicals Europe, Germany. All solvents were of HPLC grade (obtained from VWR International, Czech Republic) and dried over a layer of activated molecular sieves (4 Å) before use.
6
Synthesis and Characterization of Functional Polymers
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1,4-Dioxane, 2,2′-azobisisobutyronitrile (AIBN), 2-cyanopropan-2-yl dithiobenzoate (CTA-AIBN), 2-thiazoline-2-thiol, 2,4,6-trinitrobenzene-1-sulfonic acid (TNBSA), 3-azido-1-propylamine, 4,4′-azobis(4-cyanopentanoic acid) (ACVA), 4-cyano-4-(thiobenzoylthio)pentanoic acid (CTA-ACVA), dimethyl sulfoxide (DMSO), methacryloyl chloride, N,N-diisopropylethylamine (DIPEA), N,N-dimethylacetamide (DMA), phosphate buffered saline (phosphate buffer 0.01M and NaCl 0.154M, pH 7.4) (PBS), and t-butanol were purchased from Sigma-Aldrich (Prague, Czech Republic). 2,2′-Azobis(4-methoxy-2,4-dimethylvaleronitrile) (V-70) was from Fujifilm Wako Chemicals Europe (Neuss, Germany). 3-Amino-1-(11,12-didehydrodibenzo[b,f]azocin-5(6H)-yl)propan-1-one (DBCO-NH2) was from Click Chemistry Tools (Scottsdale, AZ, USA). N-(3-tert-butoxycarbonyl-aminopropyl)methacrylamide (APMA-Boc) was purchased from Polysciences, Inc. (Warrington, PA, USA), and 1-aminopropan-2-ol was from TCI Europe (Zwijndrecht, Belgium). All solvents and chemicals were of analytical grade.
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