Meloxicam

Manufactured by Henry Schein

Sourced in United States

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) that is used as a laboratory reagent. It functions as an inhibitor of the cyclooxygenase (COX) enzyme, which plays a role in the production of prostaglandins involved in inflammation and pain.

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Lab products found in correlation

Ketamine xylazine, by Akorn (3 mentions) Gonak, by Akorn (3 mentions) Slit lamp, by Zeiss (2 mentions) Cefazolin, by Henry Schein (2 mentions) Xylazine, by Akorn (2 mentions) Clonidine, by Merck Group (1 mentions) Heparin, by Henry Schein (1 mentions) Nicotine tartrate, by MP Biomedicals (1 mentions) Nicotine tartrate salt, by MP Biomedicals (1 mentions) Tetracaine, by Alcon (1 mentions) Ketamine, by Akorn (1 mentions) Tropicamide, by Akorn (1 mentions) Phenylephrine, by Akorn (1 mentions)

7 protocols using meloxicam

Laser-Induced Retinal Inflammation in Mice

Cited 1 time

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Male and female 10–12-week-old mice were treated as previously described [15 (link)]. Briefly, mice were anesthetized with ketamine/xylazine (Akorn, Lake Forest, IL). Pain control and hydration were achieved with a 1 mg/kg subcutaneous injection of Meloxicam (Henry Schein Animal Health, Melville, NY). Eyes were anesthetized and dilated, and a cover slip was coupled to the cornea with Gonak (Akorn) for slit lamp biomicroscopy and laser. Four (immunofluorescence) or eight (flow cytometry, to increase inflammatory cell numbers) focal burns (75 μm, 110 MW, 100 ms) were administered in each eye using a 532 nm argon ophthalmic laser (IRIDEX, Mountain View, CA) via a slit lamp (Zeiss, Oberkochen, Germany).

Droho S., Thomson B.R., Makinde H.M., Cuda C.M., Perlman H, & Lavine J.A. (2020). Ocular macrophage origin and heterogeneity during steady state and experimental choroidal neovascularization. Journal of Neuroinflammation, 17, 341.

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Laser-Induced Ocular Inflammation in Mice

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Male and female 10–12 week old mice underwent laser treatment as previously described^{23 (link)}. Briefly, mice were anesthetized with ketamine/xylazine (Akorn, Lake Forest, IL) and received 1 mg/kg subcutaneous injection of Meloxicam (Henry Schein Animal Health, Melville, NY). Eyes were anesthetized, dilated, and a cover slip was coupled to the cornea with Gonak (Akorn) for slit lamp biomicroscopy and laser. Four (immunofluorescence) or eight (flow cytometry, to increase inflammatory cell numbers) focal burns (75 μm, 100–120 mW, 100 ms) were administered in each eye using a 532 nm argon ophthalmic laser (IRIDEX, Mountain View, CA) via a slit lamp (Zeiss, Oberkochen, Germany).

Droho S., Perlman H, & Lavine J.A. (2021). Dendritic cells play no significant role in the laser-induced choroidal neovascularization model. Scientific Reports, 11, 17254.

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Clonidine and Meloxicam Effects on Neuropathic Pain

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For all experiments, an equivalent volume of 0.9% biological saline (Hospira Inc) was injected as vehicle control. The α2-agonist, clonidine (Sigma-Aldrich) was administered intrathecally at a concentration of 0.1 μg/5 μl in a total volume of 5 μl to animals having received CCI or sham, as described previously (Hylden and Wilcox, 1980 (link); Fairbanks, 2003 (link)). This dose did not induce motor dysfunction in mice (Stone et al., 2014 (link)). Investigators were blind to treatment for experiments measuring the effect of vehicle and clonidine in sham versus CCI. The nonsteroidal anti-inflammatory, meloxicam (Henry-Schein), was administered subcutaneously, into the nape of the neck, at 2 mg/kg (Kolstad et al., 2012 (link)). Testing was conducted in the OPTA using a 40°C reward zone. The effects of meloxicam versus vehicle on pain tolerance in animals having received CFA or control plantar injection was assessed.

Reker A.N., Chen S., Etter K., Burger T., Caudill M, & Davidson S. (2020). The Operant Plantar Thermal Assay: A Novel Device for Assessing Thermal Pain Tolerance in Mice. eNeuro, 7(2), ENEURO.0210-19.2020.

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Anesthetic Preparation and Administration

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Nicotine tartrate (MP Biomedicals, Solon, OH, USA) was dissolved in 0.9% sterile saline and the pH was adjusted to 7.2. Ketamine (Ketavet, St. Joseph, MO), xylazine (Akorn; Lake Forest, IL), cefazolin, meloxicam, and heparin (all from Henry Schein, Melville, NY) were administered at doses listed previously.

Powell G.L., Cabrera-Brown G., Namba M.D., Neisewander J.L., Marusich J.A., Beckmann J.S, & Gipson C.D. (2019). Economic demand analysis of within-session dose-reduction during nicotine self-administration. Drug and alcohol dependence, 201, 188-196.

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Nicotine Tartrate Administration and DREADD Viral Vectors

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(−)Nicotine tartrate salt (MP Biomedicals, Solon, OH) was dissolved in 0.9% sterile saline and adjusted to pH 7.2–7.4 with 1 M NaOH. The final stock concentration was 0.2 mg/mL free base, which was diluted to 0.02 mg/kg/mL based on body weight. DREADD Viral vectors AAV5-hsyn-DIO-mcherry (Catalog # 50459) and AAV5-hsyn-DIO-HM4D(Gi)-mcherry (Catalog # 44362) were obtained from Addgene (Watertown, MA, USA). The AAV5-hsyn-DIO-rM3D(G_s)-mcherry plasmid (Catalog # 50458) was obtained from Addgene and packaged using Penn Vector Core (Philadelphia, PA, USA). Heparin was purchased from Sagent Pharmaceuticals (Schaumburg, IL). Xylazine (100 mg/mL) was purchased from Biomeda (Cambridge, ON, Canada) and diluted to 8 mg/kg/mL with sterile saline prior to use. Ketamine was purchased from Dechra Veterinary Products (Overland Park, KS). Meloxicam and Cefazolin were both purchased through Henry Schein (Melville, NY) and diluted to 1 mg/kg and 100 mg/kg in sterile saline, respectively.

Leyrer-Jackson J.M., Overby P.F., Bull A., Marusich J.A, & Gipson C.D. (2020). Strain and sex matters: Differences in nicotine self-administration between outbred and recombinase-driver transgenic rat lines. Experimental and clinical psychopharmacology, 29(4), 375-384.

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Laser-induced Choroidal Neovascularization in Mice

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Mice were anesthetized via intraperitoneal (IP) delivery of ketamine (90 mg/kg; Akorn, Lake Forest, IL, USA)/xylazine (12 mg/kg; Akorn) cocktail. Eyes were anesthetized with 1 drop of 0.5% tetracaine (Alcon, Fort Worth, TX, USA). Pupils were dilated with 1 drop of 2.5% phenylephrine (Akorn) and 0.5% tropicamide (Akorn). The whiskers were trimmed with scissors. A subcutaneous injection of meloxicam (1 mg/kg; Henry Schein Animal Health, Melville, NY, USA) was given for pain control. Mice were moved to the slit lamp stage and a cover slip was coupled to the cornea using Goniosoft (OCuSOFT, Rosenberg, TX, USA) to allow direct retinal visualization. Mouse eyes were treated with 4 (CNV area quantitation) or 8 (flow cytometry) focal laser burns (75 um, 110 mW, 100 msec) in each eye using an IRIDEX (Mountain View, CA, USA) 532 nm argon ophthalmic laser delivered via a Zeiss (Oberkochen, Germany) slit lamp. IP injections of propranolol (20 mg/kg) or PBS were performed daily during the course of experiments.

Droho S., Cuda C.M., Perlman H, & Lavine J.A. (2019). Monocyte-Derived Macrophages Are Necessary for Beta-Adrenergic Receptor-Driven Choroidal Neovascularization Inhibition. Investigative Ophthalmology & Visual Science, 60(15), 5059-5069.

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Laser-Induced Retinal Inflammation in Mice

Cited 1 time

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Male and female 10–12 week-old mice were treated as previously described^{6 (link),11}. Briefly, mice were anesthetized with a ketamine/xylazine (Akorn, Lake Forest, IL) cocktail. Pain control and hydration were achieved with a 1 mg/kg subcutaneous injection of Meloxicam (Henry Schein Animal Health, Melville, NY). Eyes were anesthetized, dilated, and a cover slip was coupled to the cornea with Gonak (Akorn) for slit lamp microscopy and laser. Four (immunofluorescence) or eight (flow cytometry, immunohistochemistry and ELISA; to increase inflammatory cell numbers) focal burns (75 μm, 110 mW, 100 ms) were administered in each eye using a 532 nm argon ophthalmic laser (IRIDEX, Mountain View, CA) via a slit lamp delivery system (Zeiss, Oberkochen, Germany).

Droho S., Cuda C.M., Perlman H, & Lavine J.A. (2021). Macrophage-derived interleukin-6 is necessary and sufficient for choroidal angiogenesis. Scientific Reports, 11, 18084.

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