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Xav 939 s1180

Manufactured by Selleck Chemicals
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Sourced in United States

XAV-939 (S1180) is a chemical compound used as a research tool in laboratory settings. It functions as a Tankyrase inhibitor, which plays a role in various cellular processes. The core function of this product is to serve as a research tool for investigating the effects of Tankyrase inhibition in experimental models.

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Lab products found in correlation

Ab32572, by Abcam (2 mentions) Ab16663, by Abcam (1 mentions) β actin 66009 1 ig, by Proteintech (1 mentions) Olaparib s1060, by Selleck Chemicals (1 mentions) Ab32072, by Abcam (1 mentions) Mg132 s2619, by Selleck Chemicals (1 mentions) Ab41902, by Abcam (1 mentions) Ab51037, by Abcam (1 mentions) Gw3965, by Merck Group (1 mentions) β tubulin 10094 1 ap, by Proteintech (1 mentions) Dimethyl sulfoxide (dmso), by Merck Group (1 mentions) Caspase 3, by Cell Signaling Technology (1 mentions) C caspase 3, by Cell Signaling Technology (1 mentions) β tubulin, by Cell Signaling Technology (1 mentions) Bcl2 associated x (bax), by Cell Signaling Technology (1 mentions) N cadherin, by Cell Signaling Technology (1 mentions) E cadherin, by Cell Signaling Technology (1 mentions) P β catenin, by Cell Signaling Technology (1 mentions) β actin, by Cell Signaling Technology (1 mentions) Uvx radiometer, by Analytik Jena (1 mentions)

5 protocols using xav 939 s1180

1

Protein Expression and Apoptosis Assay

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Antibodies for UBE2S (14115–1-AP) and β-actin (66009–1-Ig) were purchased from Proteintech (Wuhan, China). Antibodies for PARP (9532) and caspase-3 (9662) were obtained from Cell Signaling Technology (Danvers, MA, USA). Antibodies for c-Myc (ab32072), β-catenin (ab32572), and cyclin D1 (ab16663) were acquired from Abcam (Cambridge, UK). XAV-939 (S1180) and Olaparib (S1060) were obtained from Selleck Chemicals (Houston, TX, USA). Tosyl Arginine Methyl Ester (TAME, 172104) was purchased from Sigma-Aldrich (St. Louis, MO, USA).
Hu W., Li M., Chen Y, & Gu X. (2021). UBE2S promotes the progression and Olaparib resistance of ovarian cancer through Wnt/β-catenin signaling pathway. Journal of Ovarian Research, 14, 121.
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2

Investigating SHMT2 and BRCC36 Regulation

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The siRNA oligos targeting SHMT2 and BRCC36 were obtained from Ruibo (Shanghai, China). The target sequences of the siRNA oligos were as follows.
si-SHMT2 #1, 5' CCACAATCATGCCATTGCT3'
si-SHMT2 #2, 5'CCTGCAGGTTCTGAAGAAT3'
si-BRCC36 #1, 5'GCAGGAATTACAACAAGAA3'
si-BRCC36 #2, 5'GAAAGTGTGCCTTGAATCA3'
Proteasome inhibitor MG132 (S2619), Wnt pathway inhibitors XAV939 (S1180), and iCRT-14 (S8704) were purchased from Selleck (TX, USA). Cycloheximide (CHX) (239763) was purchased from Millipore (Darmstadt, Germany).
Liu C., Wang L., Liu X., Tan Y., Tao L., Xiao Y., Deng P., Wang H., Deng Q., Lin Y., Jie H., Zhang H., Zhang J., Peng Y., Zhang H., Zhou Z., Sun Q., Cen X, & Zhao Y. (2021). Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting β-catenin degradation. Theranostics, 11(6), 2966-2986.
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3

Quantitative Analysis of Wnt Signaling Pathway

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Anti-LXRα (ab41902), anti-β-catenin (ab32572), anti-CD44 (ab51037), and anti- Cyclin D1 (ab134175) antibodies were supplied by Abcam (Abcam, USA). GAPDH (10949-1-AP) and β-tubulin (10094-1-AP) antibodies were supplied by Proteintech Group (Proteintech, USA). Dimethyl sulfoxide and GW3965 were purchased from Sigma-Aldrich (St Louis, MO, USA). XAV939 (S1180) and Wnt agonist 1 (S8178) were purchased from Selleck (Selleck, USA).
Gao Y., Chen Z., Wang R., Tan X., Huang C., Chen G, & Chen Z. (2019). LXRα Promotes the Differentiation of Human Gastric Cancer Cells through Inactivation of Wnt/β-catenin Signaling. Journal of Cancer, 10(1), 156-167.
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4

Wnt/β-catenin Signaling Pathway Analysis

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Antibodies directed against β-catenin, p-β-catenin, E-cadherin, N-cadherin, Bax, Bcl, c-caspase 3, caspase 3, β-actin, and β-tubulin were purchased from Cell Signaling Technologies (Danvers, MA, USA). Antibodies directed against histone H3 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA). Antibodies directed against WDR74 were purchased from OriGene (Rockville, MD, USA). Antibodies directed against lef1, TCF1, c-myc, and cyclin D1 were purchased from Abisin (Shanghai, China). XAV-939(S1180), a Wnt/β-catenin signaling pathway-specific inhibitor, was purchased from Selleck Chemicals (Houston, TX, USA).
Cai Z., Mei Y., Jiang X, & Shi X. (2021). WDR74 promotes proliferation and metastasis in colorectal cancer cells through regulating the Wnt/β-catenin signaling pathway. Open Life Sciences, 16(1), 920-929.
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5

TRPA1 Signaling Pathway Regulation

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TRPA1 (19124-1-AP) was purchased from Proteintech Group (Rosemont, IL 60018, USA). CaMKII (4436), pCaMKII (12716), β-catenin (8480) were purchased from Cell Signaling Technology (Danvers, Massachusetts, USA). Retinal (R2500), JT010 (SML1672), HC030031 (H4415) were purchased from Sigma Aldrich (Darmstadt, Germany). Dimethyl sulfoxide (DMSO), RIPA buffer (R0100), BCA protein assay kit (PC0020), poloxamer gel (Polyethylene-polypropylene glycol 407, S7071) and formalin (G2161) were purchased from Solarbio (Beijing, China). Protease inhibitor cocktail (B14011) was purchased from Bimake (Shanghai, China). XAV-939 (S1180) was purchased from Selleck Chemicals (Shanghai, China). Fluo-4 AM (ab142773), DIO Staining Solution (C1038) were purchased from Beyotime (Shanghai, China). Stock solutions were prepared as follows: HC030031, and XAV-939 were dissolved in DMSO, JT010, and retinal in absolute ethanol. Masson-Fontana staining solution (G2032) was purchased from Solarbio (Beijing, China). Opti-MEM medium (31985062), Lipofectamine 2000 (11668030) and chemiluminescence (ECL) were obtained from Thermo Fisher Scientific (Massachusetts, USA). The UVA or UVB source used was a 9W UVA or UVB broadband lamp (Philips, Eindhoven, Netherlands) and radiation energies were measured using a UVX radiometer (UVP, Upland, California, USA).
Liu Y., Li Z., Wu W., Wang Y., Zhao G., Liu Y., Liu J, & Song Z. (2022). UVR Promotes Keratinocyte Phagocytosis and Skin Pigmentation Through TRPA1 Channels. Clinical, Cosmetic and Investigational Dermatology, 15, 1183-1193.
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