Tgf β1 3

Manufactured by Santa Cruz Biotechnology

Sourced in United States

TGF-β1–3 is a set of three cytokines that belong to the transforming growth factor beta (TGF-β) family. They are essential mediators of various cellular processes, including cell growth, differentiation, and immune regulation.

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2 protocols using tgf β1 3

Investigating TGF-β and NF-κB Pathways

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The following primary antibodies were used from Santa Cruz Biotechnology: pERK (T202/Y204), ERK1/2, TGF-β1–3, TGF-β1 siRNA, SMAD2 siRNA, siRNA, control siRNA, and β-actin. The following primary antibodies were used from Cell Signaling: NF-κBp65 (p65), PUMA, bcl-2, Mcl-1, Bcl-XL, PARP, Bax, Bak, Bid, Bim, and Caspase-3. NF-κBp65 siRNAs and hrTGF-β1 were from Applied Biosystems. MEK/ERK inhibitor U0126 was purchased from Cell Signaling Technology. Anti-Ki67 Ab was from Thermo Scientific. Inhibitors were tested for monotherapy and combination therapy: U0126:10 mM. Cells incubated with culture medium or culture medium with DMSO served as controls.

Yin Q., Liu S., Dong A., Mi X., Hao F, & Zhang K. (2016). Targeting Transforming Growth Factor-Beta1 (TGF-β1) Inhibits Tumorigenesis of Anaplastic Thyroid Carcinoma Cells Through ERK1/2-NF-κB-PUMA Signaling. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 22, 2267-2277.

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Antibody Detection in TGF-β Signaling

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Antibodies against TGF-β1-3, TβRII, and ALK5 (TβRI) were from Santa Cruz Biotechnology Inc. (Santa Cruz, CA, USA). Antibodies against Smad2, 3, 4, and 7 and P-Smad2 were kindly provided by professors Carl-Henrik Heldin and Peter ten Dijke. The antibodies were generated and purified as previously described [20 (link)].

Akbarshahi H., Sam A., Chen C., Rosendahl A.H, & Andersson R. (2014). Early Activation of Pulmonary TGF-β1/Smad2 Signaling in Mice with Acute Pancreatitis-Associated Acute Lung Injury. Mediators of Inflammation, 2014, 148029.

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