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Gamma counter

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The Gamma Counter is a laboratory instrument designed to measure the radioactivity of samples by detecting and quantifying gamma radiation. It provides precise measurements of the amount of gamma-emitting isotopes present in a sample.

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Lab products found in correlation

Synergy h4, by Agilent Technologies (1 mentions) Q exactive plus hybrid quadrupole orbitrap mass spectrometer, by Thermo Fisher Scientific (1 mentions) Advance 2 spectrometer, by Bruker (1 mentions) Inveon mm ct system, by Siemens (1 mentions) 1470 automatic gamma counter, by PerkinElmer (1 mentions) Inveon dpet, by Siemens (1 mentions)

4 protocols using gamma counter

1

Comprehensive Hormone and Metabolic Profile

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Blood samples were obtained between 08:00 AM and 10:00 AM after 12 hours of fasting. Serum was separated and stored at −20°C until further analyses. Follicle stimulating hormone (FSH), luteinizing hormone (LH), free testosterone, estradiol (E2), progesterone, free thyroxin (FT4), free triiodothyronine (FT3), and thyroid stimulating hormone (TSH) levels were measured with standard radioimmunoassay (RIA) on gamma counter (Capintec, USA). Immunoradiometric (IRMA) kit (Diagnostic Systems Laboratories, USA) was used for assaying serum leptin levels. The sensitivity of leptin IRMA kit (lowest detectable limit) was 0.1 ng per milliliter and intra- and interassay coefficients of variations were less than 8%. Fasting blood glucose (FBG) concentrations were determined by glucose oxidase method.
Baig M., Rehman R., Tariq S, & Fatima S.S. (2014). Serum Leptin Levels in Polycystic Ovary Syndrome and Its Relationship with Metabolic and Hormonal Profile in Pakistani Females. International Journal of Endocrinology, 2014, 132908.
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2

Analytical Characterization of Compounds

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Mass spectra and
ESI-MS in positive
and negative modes were generated using an in-house Agilent 6310 system
ion trap. Proton and carbon NMR spectra too were acquired using an
in-house Bruker ADVANCE II spectrometer (1H NMR and 13C NMR, 400 and 100 Hz). A well-type calibrated Capintec Gamma
counter was used for radiolabeling counting. The MTT assay absorbance
was acquired using a BioTek Synergy H4 hybrid multiplate reader. MicroSPECT
acquisitions were performed using a GE_FLEX Triumph MicroPET/SPECT/CT
triple-modality system. HRMS was done using a Thermo Scientific Q
Exactive Plus Hybrid Quadrupole-Orbitrap mass spectrometer.
Jaswal A.P., Hazari P.P., Prakash S., Sethi P., Kaushik A., Roy B.G., Kathait S., Singh B, & Mishra A.K. (2022). [99mTc]Tc-DTPA-Bis(cholineethylamine) as an Oncologic Tracer for the Detection of Choline Transporter (ChT) and Choline Kinase (ChK) Expression in Cancer. ACS Omega, 7(15), 12509-12523.
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3

PET Imaging of Copper-64 Labeled Antibody

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Mice were anesthetized with 3.0% isoflurane in oxygen and maintained under 1.5–2.0% isoflurane. 64Cu-169cDb (4.15 ± 1.11 μg/animal, 6.78 ± 1.22 MBq/animal) was administered by tail vein injection and PET imaging was conducted on an Inveon DPET small animal PET scanner (Siemens Medical Solutions USA, Knoxville, TN) for 30 min at 0, 5 and 24 h post injection. After each PET scan, the animals were moved to a small animal Inveon MM CT system (Siemens Medical Solutions USA, Knoxville, TN) and a CT scan was conducted to obtain anatomical information for co-registration of PET/CT images. Whole body activity was measured between scans with a gamma-counter (Capintec, Inc. NJ). After the final imaging time point, mice were euthanized by cervical dislocation under deep isoflurane. Blood, urine and organs (thymus, bone, stomach, intestine, liver, spleen, kidneys, heart, lungs, thigh muscle), lymph nodes (inguinal, axillary, mesenteric, cervical), and tumors were harvested for biodistribution analysis using a 1470 automatic gamma counter (PerkinElmer, CT) after which organs weights were taken on a microbalance. In some cases, organs were briefly scanned to obtain ex-vivo PET data and organs were evaluated with histological stains.
Seo J.W., Tavaré R., Mahakian L.M., Silvestrini M.T., Tam S., Ingham E.S., Salazar F.B., Borowsky A.D., Wu A.M, & Ferrara K.W. (2018). CD8+ T-cell density imaging with 64Cu-labeled cys-diabody informs immunotherapy protocols. Clinical cancer research : an official journal of the American Association for Cancer Research, 24(20), 4976-4987.
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4

Pharmacokinetics of 131I-NM-02 in Mice

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The pharmacokinetic profile of 131I-NM-02 was studied in five 6-week-old normal ICR mice. Each mouse was administered 740 kBq 131I-NM-02, corresponding to 1 μg of NM-02 in 200 μL of saline. Blood was collected in 10-μL capillary tubes at designated time points (1, 2, 5, 15, 30, 60, 90, and 120 min). The radioactivity of the blood samples was measured using a gamma counter (Capintec, Florham Park, NJ, USA) to calculate the percentage of injection dose per gram (% ID/g) of the wet tissue. Pharmacokinetic data were analyzed using DAS 2.0 (Shanghai, China), and the half-life of 131I-NM-02 in the blood was analyzed using a three-compartment model.
Zhao L., Gong J., Qi Q., Liu C., Su H., Xing Y, & Zhao J. (2023). 131I-Labeled Anti-HER2 Nanobody for Targeted Radionuclide Therapy of HER2-Positive Breast Cancer. International Journal of Nanomedicine, 18, 1915-1925.
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