For PET scans, [11C]PiB scans were acquired on Siemens ECAT HR + PET scanners at both sites using a nominal dose of 15 mCi of radiotracer. Preprocessing of dynamic [11C]PiB data was performed in AIR, version 3.0 [26] . Dynamic PET data were corrected for inter frame motion and averaged over 50–70 min after injection. Parametric SUVR images were generated using a cerebellar gray matter ROI. For MRI scans, T1-weighted MRIs were acquired on a 3.0 T GE SIGNA 750 at the University of Wisconsin-Madison site and on a 3.0 T Siemens Magnetom Trio at the University of Pittsburgh Medical Center site. The SIGNA 750 acquisition used high-resolution volumetric spoiled gradient sequence (TI/TE/TR = 450/3.2/8.2 ms, flip angle = 12°, slice thickness = 1 mm no gap, matrix size = 256 × 256 × 156), whereas the Magnetom Trio acquisition used a magnetization prepared rapid acquisition gradient echo sequence (TI/TE/TR = 900/2.98/2300 ms, flip angle = 9°, slice thickness = 1.2 mm, matrix size = 160 × 240 × 256).
Ecat hr pet scanner
Manufactured by Siemens
Sourced in Germany
The ECAT HR PET scanner is a positron emission tomography (PET) device manufactured by Siemens. It is designed for high-resolution imaging of the human body. The scanner uses advanced technology to detect and measure the distribution of radioactive tracer substances in the body, providing detailed information about its internal structure and function.
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25 protocols using ecat hr pet scanner
1
PiB-PET and MRI Imaging Protocol
2
Synthesis and PET Imaging of [11C]PiB
3
PET Imaging of Amyloid Deposition
4
PET Imaging of Amyloid Deposition
5
PET Imaging of Amyloid Deposition
6
Neuroimaging of Amphetamine Effects
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Participants were scanned on a Siemens ECAT HR + PET scanner (CTI/Siemens, Knoxville, Tennessee) with lead septa removed (63-slice coverage), with a maximum resolution 4.2-mm, full width at half maximum (FWHM) in the center of the field of view. Attenuation correction was performed using a 12-min 68Ga transmission scan immediately prior to tracer injection. The emission scan started simultaneously with the injection of [11C]raclopride, as an i.v. bolus, and data were acquired for 60 min in 26 time frames of progressively longer duration. Vital signs were monitored and blood samples for plasma amphetamine collected just prior to capsule administration, at the time of tracer administration, mid-scan, and at the end of scan.
High-resolution (1 mm) T1-weighted magnetic resonance images (MRI) were obtained on a 1.5-Tesla Siemens scanner, using gradient echo pulse sequence (TR = 22 ms, TE = 9.2 ms, flip angle = 30°, FOV = 256 mm, and matrix 256 × 256).
High-resolution (1 mm) T1-weighted magnetic resonance images (MRI) were obtained on a 1.5-Tesla Siemens scanner, using gradient echo pulse sequence (TR = 22 ms, TE = 9.2 ms, flip angle = 30°, FOV = 256 mm, and matrix 256 × 256).
7
PET Imaging of Amyloid Deposition
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PET scans were collected on a Siemens ECAT HR PET scanner (Siemens, Malvern, PA) housed at UT Southwestern Medical School. Participants were injected with 370 MBq (10 mCi) of 18F-florbetapir (Avid Radiopharmaceuticals/Eli Lilly, Indianapolis, IN). Approximately 30 minutes after injection, participants were placed on the imaging table. A 2-minute scout was acquired to ensure that the brain was within the field of view. Fifty minutes after injection, an internal rod source transmission scan was acquired for 7 minutes, followed immediately by a dynamic emission acquisition of 2 frames by 5 minutes each. The transmission image was reconstructed using back-projection with a 6-mm full width at half-maximum gaussian filter. Emission images were processed by iterative reconstruction, 4 iterations and 16 subsets with a 3-mm full width at half-maximum ramp filter.
8
18F-florbetapir PET Imaging Protocol
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After an intravenous bolus injection of 10 mCi 18 F-florbetapir (also called AV45), participants were positioned in a Siemens (Munich, Germany) ECAT HR PET scanner for data acquisition, using laser guidance for precise head positioning. Velcro straps and foam wedges were used to secure the participant's head. To ensure the brain was completely in the field of view and absent of rotation in either the transverse or sagittal planes, a 2-minute scout scan was acquired. At 50 minutes post-injection, 2 frames of 5-minute PET emission scan and a 7-minute transmission scan were acquired in 3D mode using the following parameters: matrix size = 128 × 128, resolution = 5 mm × 5 mm, slice thickness = 2.42 mm, and field of view = 58.3 cm. Emission images were processed by iterative reconstruction, 4 iterations, and 16 subsets with a 3-mm full width at half maximum (FWHM) ramp filter. The transmission image was reconstructed using back-projection and a 6-mm FWHM Gaussian filter for attenuation correction 47, (link)48 (link) .
9
18F-florbetapir PET Imaging in aMCI
10
PET Imaging of Amyloid Deposition
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