Achieva nova dual

MRI data were obtained using a 1.5T MR scanner (Achieva Nova-Dual; Philips, Best, the Netherlands) in the Department of Medical Imaging, Guangdong No. 2 Provincial People's Hospital. Each subject lay supine with the head comfortably fixed using a belt and foam pads. During Rs-fMRI, subjects were instructed to close their eyes and remain as quiet as possible and to not think of anything systematically or fall asleep. The conventional imaging sequences including T1-weighted images and T2-FLAIR images were obtained for every subject to detect clinically silent lesions. Rs-fMRI data were acquired using a gradient-echo echo-planar sequence sensitive to blood oxygenation level dependent (BOLD) contrast. The Rs-fMRI acquisition parameters were as follows: repetition time (TR)  = 3,000 ms, echo time (TE)  = 50 ms, flip angle  = 90°, field-of-view  = 230×230 mm², matrix  = 64×64, and total volumes  = 160. A total of 33 axial slices of 4.5 mm thickness were collected with no intersection gap. In-plane resolution was 3.59×3.59 mm². Each Rs-fMRI scan lasted 8 minutes. After the examination, all participants were asked questions to verify the degree of their cooperation.

All MR imaging data were acquired with a 1.5T MR scanner (Achieva Nova Dual; Philips Medical Systems, Best, Netherlands), using a 16-channel neurovascular (NV) coil. Foam padding was used to limit head movement. Before the rs-fMRI scan, conventional MR imaging sequences including T₁-weighted images [repetition time (TR) = 600 ms, echo time (TE) = 29 ms] and T₂-FLAIR images [TR = 6000 ms, TE = 120 ms, and inversion time (TI) = 2000] were performed in every participant to detect clinically silent lesions. During rs-fMRI scan, participants were instructed simply to rest with their eyes closed, to remain as motionless as possible, to not think of anything in particular, and to not fall asleep. Whole-brain rs-fMRI data were acquired by using an echo planar imaging (EPI) sequence with the following parameters: TR = 3000 ms, TE = 50 ms, flip angle = 90°, field of view (FOV) = 23 × 23 cm², matrix = 64 × 64, and 4.5 mm slice thickness with no gap. Each brain volume comprised 33 axial slices, and 160 image volumes were collected in each functional run. Each rs-fMRI scan lasted 8 minutes. After the MR examination, each participant was asked some questions to check the degree of collaboration.

MR imaging data were acquired for all subjects using a 1.5-T MR scanner (Achieva Nova-Dual, Philips Medical Systems, Best, Netherlands). Each subject lay in the supine position with the head snugly fixed with foam pads and a belt. The routine acquisition of T₁-weighted and T₂-FLAIR images was performed for each subject to detect clinically silent lesions in the central nervous system. High-resolution three-dimensional T₁-weighted (3D-T₁) images covering the entire brain were acquired in the sagittal orientation using a fast field echo (FFE) sequence (S1 Data). The imaging parameters were as follows: repetition time = 25 ms, echo time = 4.1 ms, flip angle = 30°, field of view = 230 × 230 mm, matrix = 231 × 231, slice thickness = 1 mm, and number of slices = 160.

The fast field echo (FFE) three-dimensional T1-weighted (3D-T1WI) data were acquired by a 1.5-T MR scanner (Achieva Nova Dual; Philips Medical Systems, Best, Netherlands) with a 16-channel neurovascular coil. Additionally, we acquired other sequences to exclude other intracranial diseases. Detailed imaging parameters were provided in Supplementary Material.

All children were asked to fast for 8 h and forego liquid intake for 4 h before MRI examination. Before the examination, all children were trained to practice holding their breath for several seconds according to our instructions. During the examination, all children were asked to breathe freely and to hold their breath alternately. A 1.5-T MRI scanner (Achieva Nova Dual; Philips, Best, the Netherlands) was used to perform a coronal BOLD-MRI scan focused on the renal hilum using a gradient-echo echoplanar imaging sequence. Sixteen echo time chain and fast field echo sequences were used. The following scanning parameters were used: field of view 200×282×70 mm; slice thickness 5 mm; number of slices 12; repetition time 400 ms; voxel size 3×3 mm; and flip angle 45°. Each scan was completed as the subjects held their breath.