Ge signa 3.0 t scanner

[¹¹C]K-2 was synthesized at Yokohama City University Hospital in accordance with the good manufacturing practice ordinance and was certified by the Japanese Society of Nuclear Medicine. PET imaging was performed with a Toshiba Aquiduo scanner (Toshiba Medical), which provided an axial field of view (FOV) of 240 mm and 80 contiguous 2.0-mm-thick slices. A 4.7-s transmission scan was performed for attenuation correction, and a 60-s intravenous injection of [¹¹C]K-2 (378 ± 19 MBq) was administered, followed by an emission scan of 90 min, with frames of 12 × 10, 2 × 30, 7 × 60 s, 1 × 2, 1 × 3, 3 × 5 and 6 × 10 min. Dynamic images were reconstructed with a 2D-ordered subset expectation maximization using four iterations, 14 subsets, a 128 matrix, a zoom of 2.8 and a 5.0-mm Gaussian filter. To permit the accurate delineation of brain regions for data analysis, each participant underwent an MRI scan on a GE SIGNA 3.0-T scanner (GE Medical Systems). Images were acquired with a proton-density-weighted sequence [time to echo = 17 ms, repetition time = 6000 ms, FOV = 22 cm (two-dimensional), matrix = 256 × 256, slice thickness = 2 mm and number of excitations = 2].

Whole-brain imaging data were acquired on a GE-Signa 3.0T scanner (General Electric, Milwaukee, WI) at the University of Georgia Bio-Imaging Research Center (birc.uga.edu). A total of 213 functional images were acquired using a gradient echo T2*-weighted echoplanar imaging (EPI) scan and were obtained using a flip angle of 90°, repetition time (TR) = 2.0s, echo time (TE) = 25ms, 40 slices, and a field of view (FOV) = 220mm x 220mm, matrix = 64 x 64. For structural whole brain images, a three-dimensional high-resolution spoiled gradient scan (FSPGR) (repetition time, 24 msec; echo time, 4.5 msec; flip angle, 20°; matrix size, 256 x 256; field of view, 25.6 cm; slice thickness, 1.0 mm; 164 contiguous slices) was conducted.