Sodium alginate c6h7nao6 n

A polyacrylamide-sodium alginate dual-network hydrogel with well controlled drug-release properties was selected as the drug carrier [39 (link)]. Acrylamide (C₃H₅NO, Lot No. 20220401), sodium alginate ((C₆H₇NaO₆)_n, Lot No. 20210901), N, N-methylene-bis-acrylamide (C₇H₁₀N₂O₂, Lot No. 20210115), ammonium persulfate ((NH₄)₂S₂O₈, Lot No. 20211023) and calcium chloride anhydrous (CaCl₂, Lot No. 20210710) were all purchased from Sinopharm Chemical Reagent Co., Ltd., Shanghai, China.
For its broad-spectrum antibiotic in the pharmaceutical field, the tetracycline hydrochloride (C₂₂H₂₄N₂O₈·HCl, Lot No. G2116343, Shanghai Aladdin Biochemical Technology Co., Ltd., Shanghai, China) was used as a model drug [40 (link)]. The molecular weight is 480.9 g/mol and its saturation concentration in water is 41.59 mol/m³.

Sodium alginate (C₆H₇NaO₆)_n (molecular weight 196 kDa), calcium chloride (CaCl₂), and disodium hydrogen phosphate dodecahydrate (Na₂HPO₄.12H₂O) were purchased from Sinopharm Chemical Reagent Co., Ltd. (Shanghai, China). Xanthan gum was provided by Lavendersoap (New York, NY, USA). Tween 20 was purchased from Duksan Pharmaceutical Co., Ltd. (Ansan-si, South Korea). Bovine lactoferrin (bLf) was supplied by Sigma-Aldrich (St. Louis, MO, USA). Agar and de Man–Rogosa–Sharpe (MRS) broth were supplied by Solar-Bio Science and Technology Co., Ltd. (Beijing, China). All other reagents and chemicals used were of analytical grade and used without further processing unless otherwise stated.