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Risperidone

Manufactured by Thermo Fisher Scientific
Sourced in Belgium

Risperidone is a laboratory reagent used in various analytical and research applications. It is a chemical compound with the molecular formula C₂₃H₂₇FN₄O₂. Risperidone is commonly used as a reference standard or analytical tool in a range of scientific disciplines, including but not limited to pharmaceutical, biochemical, and clinical research.

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2 protocols using risperidone

1

Pharmacological Dietary Interventions in Rodents

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All diets were prepared by Research Diets and shared the same macronutrients (21% kcal protein, 34% kcal carbohydrate, and 45% kcal fat), ingredient composition (Casein 800 kcal, DL-Methionine 12 kcal, cornstarch 200 kcal, maltodextrin 400 kcal, sucrose 695 kcal, corn oil 450 kcal, lard 1,305 kcal, and vitamin mix 40 kcal), and energy density (4.76 kcal/g). Risperidone (Cat# AC459390010; Acros Organics) was mixed into a control diet D09092903 to make the Risperidone diets D18041008 (25 mg/kg) and D18041007 (100 mg/kg). Similarly, olanzapine (Cat# 356941G; ChemPacific) was mixed into the same control diet D09092903 to make the olanzapine diet as we described previously (Lord et al., 2017 (link)). All diets are available for purchase at the vendor.
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2

Polymeric Microparticles for Drug Delivery

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The PLGA was obtained from Evonik (Darmstadt, Germany) under the commercial name Resomer® RG. PLGA grades of 50:50 lactic to glycolic acid ratio and of different molecular weights (Mw) and either acid- or ester-terminated were obtained: Resomer® RG 503H (acid-terminated, Mw 24 000–38 000); Resomer® RG 504 (ester-terminated, Mw 38 000–54 000); and Resomer® RG 505 (ester-terminated, Mw 54 000–69 000). Ethyl cellulose was obtained under the commercial name EthocelTM Standard 7 Premium from Dow (Midland, MI, USA). Risperidone and flurbiprofen were obtained from Acros Organics (Geel, Belgium). Lidocaine and agarose type I-B were obtained from Sigma-Aldrich. All other chemicals were of analytical grade or higher.
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