In vivo DSI acquisitions of healthy volunteers are acquired on a 3T clinical scanner (Prisma, Siemens, Erlangen; 64ch head coil; 80 mT/m; Twice Refocused Spin Echo EPI sequence; RDSI q-space sampling (Baete et al., 2016 (link)), 4 shells, 200, 1500, 2750, 4000 mm2/s; TR=2000 (bootstrap) / 8500 (whole brain) ms, TE = 86 ms, 10 (bootstrap) / 50 (whole brain) slices, field of view 200×200 mm2, 2.5×2.5×2.5 mm3 resolution, partial Fourier 5/8). For each volunteer either whole brain or limited coverage datasets (five replications) for boot-strapping are acquired. For image correction an extra b0-dataset is acquired with PA phase encoding rather than AP phase encoding. A T1-weighted gradient-echo sequence (MPRAGE) serves as a reference for image registration (TR=2300 ms, TE=2.87 ms, 192 slices, 1×1×1 mm3 resolution, TI=900/1000 ms, 5 min 03 s) The protocol was approved by an Institutional Review Board.
A high resolution preprocessed in vivo DWI acquisition was provided by the Human Connectome Project (HCP) consortium led by Washington University, University of Minnesota, and Oxford University. We used a single subject from the MGH datasets (3T Siemens Skyra System; 64ch head coil; 1000, 3000, 5000 mm2/s, 256 q-space volumes, TR=8800 , TE=57 ms, 96 slices, field of view 210×210 mm2, 1.5×1.5×1.5 mm3 resolution, partial Fourier 5/8, GRAPPA 3; healthy volunteer).
A high resolution preprocessed in vivo DWI acquisition was provided by the Human Connectome Project (HCP) consortium led by Washington University, University of Minnesota, and Oxford University. We used a single subject from the MGH datasets (3T Siemens Skyra System; 64ch head coil; 1000, 3000, 5000 mm2/s, 256 q-space volumes, TR=8800 , TE=57 ms, 96 slices, field of view 210×210 mm2, 1.5×1.5×1.5 mm3 resolution, partial Fourier 5/8, GRAPPA 3; healthy volunteer).