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Discovery mr901

Manufactured by GE Healthcare
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The Discovery MR901 is a magnetic resonance imaging (MRI) system developed by GE Healthcare. It is designed to produce high-quality images of the human body for diagnostic purposes. The core function of the Discovery MR901 is to generate detailed images of internal structures and organs using powerful magnetic fields and radio waves.

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Fluorinert, by 3M (1 mentions)

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MR901

4 protocols using discovery mr901

1

High-Resolution 7T MRI Cartilage Evaluation

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High resolution MR imaging at 7T was performed at a horizontal bore 7T small animal scanner (Discovery MR901, GE Healthcare, Chalfont St. Giles, United Kingdom) using a 2-channel surface coil. For morphological cartilage evaluation, the MR examination included a 3D IM-w fs TSE sequence (TR, 3,000ms; TE, 20ms; matrix, 384x384; FOV, 60; slices, 72; slice thickness, 0.5mm; gap 0.5mm; bandwidth, 244 Hz/pixel). For quantitative relaxation time measurements, a sagittal 2D multi-slice multi-echo (MSME) spin-echo T2 mapping sequence was acquired (TR, 2000ms; TE, 8 echo times (10.6, 21.1, 31.7, 42.2, 52.8, 63.3, 73.9, 84.4ms); matrix 64x64; FOV, 30; slices, 66; slice thickness 0.5mm; gap 0.5mm; bandwidth, 299 Hz/pixel).
Herzen J., Karampinos D.C., Foehr P., Birnbacher L., Viermetz M., Burgkart R., Baum T., Lohoefer F., Wildgruber M., Schilling F., Willner M., Marschner M., Noël P.B., Rummeny E.J., Pfeiffer F, & Jungmann P.M. (2019). 3D grating-based X-ray phase-contrast computed tomography for high-resolution quantitative assessment of cartilage: An experimental feasibility study with 3T MRI, 7T MRI and biomechanical correlation. PLoS ONE, 14(2), e0212106.
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2

High-resolution MRI of Iron-Sensitive Brain Tissue

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Five AD (A1–A5) and 8 normal control (N1–N8) formalin-fixed human brain specimens were obtained from neuropathology (Table 1). Each specimen consisted of 3-cmby 3-cmsquare by 4-mm thick slabs from the frontal lobe, parietal lobe, medial temporal lobe, superior temporal gyrus, and occipital lobe. These sections from specimens A1–A5 and N1–N5 were separated by a thin plastic sheet and immersed in Fluorinert (3M, USA) in a 4-cm diameter sealed container within a scaffold to ensure nomotion (Fig.1A).MR imaging was performed using a 2-cm long transmit and/or receive radiofrequency solenoid coil (Fig. 1B) at 7T (GE/Agilent Discovery MR901). We used a modified balanced steady-state free precession sequence (bSSFP) for all imaged specimens as well as a gradient echo (GRE) sequence for A1–A5 and N4 (coronal 3D bSSFP or GRE acquisition, repetition time 21, echo time 10.5, flip angle 20, phase cycles 8 for bSSFP, number of excitations 8 for GRE, 0.1-mm isotropic voxels, field-of-view (FOV) 3 cm, 256 slices, bandwidth 8 kHz, total scan time 3 hours 37 minutes each, Fig.1C). Both sequences are highly and similarly iron sensitive. All the images were acquired at 0.1-mm isotropic voxel size and reconstructed at 0.0586 × 0.0586 in-plane with 0.1-mm slice thickness using a standard reconstruction.
Zeineh M.M., Chen Y., Kitzler H.H., Hammond R., Vogel H, & Rutt B.K. (2015). Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease. Neurobiology of aging, 36(9), 2483-2500.
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3

Contrast-Enhanced 7T MRI in Arthritis

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Control mice (Ctrl), animals with collagen-induced arthritis (RA) and RA mice treated with standard therapy (RA+Th) were examined before collagen induction (day -1) and twice during RA development (day 32 and day 42) with contrast-enhanced 7T MRI and clinical scoring at the same time points. The imaging time points were chosen according to the appearance of clinical symptoms (S1 Fig). MR images were acquired on 7T small animal MRI system (Discovery MR901, GE Healthcare, Waukesha, Wisconsin, USA and Agilent Technologies, Oxford, UK). Mice were anaesthetized with isoflurane and placed with a hind leg on a 2 cm single-channel receive coil (RAPID Biomedical, Rimpar, Germany). A 2D multislice T1 weighted spoiled gradient recalled echo sequence was used, with 5 slices of 0.25 mm slice thickness, TR 50 ms, TE 3.9 ms, flip angle 30 degrees, receive bandwidth 46.9 kHz, and 150 averages, matrix size 192x96 and field of view 15 mm x 7.5 mm. Image slices were oriented parallel to the bones of the hind leg, perpendicular to the surface of the paw. Images were acquired before, immediately after, and 20 min after tail vein injection of 100 μmol/kg body weight Gadofluorine P (invivoContrast GmbH, Berlin, Germany), an experimental contrast agent with increased affinity to extracellular matrix proteins.
Gassert F.T., Gassert F.G., Topping G.J., Rummeny E.J., Wildgruber M., Meier R, & Kimm M.A. (2019). SNR analysis of contrast-enhanced MR imaging for early detection of rheumatoid arthritis. PLoS ONE, 14(3), e0213082.
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4

Non-Destructive Iron Detection in Bulk Samples

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Specimens (before fixation) were examined using high-resolution MRI at 7T (GE/Agilent Discovery MR901) at room temperature. Gradient echo sequences (GRE) were acquired (full sequence parameters in Supplementary Table S1). This method can be used to initially locate iron deposits non-destructively in fresh and bulk samples as iron oxide is magnetic and therefore serves as a natural T2 contrast agent for MRI. For other mineral deposits in tissues that are non-magnetic, the MRI is omitted and the evaluation proceeds directly to histology studies with proper staining as detailed in the following section.
Zeng Y., DiGiacomo P.S., Madsen S.J., Zeineh M.M, & Sinclair R. (2021). Exploring valence states of abnormal mineral deposits in biological tissues using correlative microscopy and spectroscopy techniques: a case study on ferritin and iron deposits from Alzheimer’s disease patients. Ultramicroscopy, 231, 113254.
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