Mct flow pet ct scanner

Manufactured by Siemens

The MCT Flow PET/CT scanner is a medical imaging device designed for simultaneous positron emission tomography (PET) and computed tomography (CT) scanning. It is used for the acquisition of functional and anatomical data in a single examination.

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Lab products found in correlation

Biograph 16hr pet ct, by Siemens (1 mentions) Discovery mr750, by GE Healthcare (1 mentions)

Close spelling variants of this product

Siemens scanners (11 citations) Biograph mCT Flow PET/CT scanner (11 citations) MCT PET/CT scanner (10 citations) PET/CT scanner (10 citations) CT scanners (7 citations) Biograph mCT Flow 20-4R PET/CT scanner (3 citations)

3 protocols using mct flow pet ct scanner

Synthesis and PET/CT Imaging of 18F-FDG and 18F-FES

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The synthesis and quality control of ¹⁸F-FDG and ¹⁸F-FES were performed as reported in our previous study (15 (link)).
¹⁸F-FDG PET/CT imaging was done according to standard clinical procedures. All patients fasted for at least 6 h and had serum glucose levels less than 10 mmol/L before the intravenous injection of ¹⁸F-FDG (3.7–7.4 MBq/kg). The patients were kept lying comfortably in a quiet, dimly lit room before and after the tracer injection. About 1 h after tracer injection, the patients were administered 1 L of plain water orally and then scanned in the PET/CT (Siemens Biograph 16HR PET/CT or mCT Flow PET/CT scanner). About 222 MBq of ¹⁸F-FES was injected intravenously over 1–2 min. The scanning was initiated 1 h after administration of the tracer on the same PET/CT scanner as the ¹⁸F-FDG. The detail of PET/CT acquisition parameters were described as reported in prior studies (16 (link)).

Liu C., Xu X., Yuan H., Zhang Y., Zhang Y., Song S, & Yang Z. (2020). Dual Tracers of 16α-[18F]fluoro-17β-Estradiol and [18F]fluorodeoxyglucose for Prediction of Progression-Free Survival After Fulvestrant Therapy in Patients With HR+/HER2- Metastatic Breast Cancer. Frontiers in Oncology, 10, 580277.

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Standardized 18F-FDG PET/CT Imaging Protocol

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¹⁸F‐FDG was generated automatically by a cyclotron. Patients were asked to fast for 6 h or more before the exam, and the blood glucose was less than 10 mmol/L before the injection of ¹⁸F‐FDG (dose: 3.7 MBq/kg). Patients laid on a comfortable cushion in a quiet room during the injection.
PET/CT scans were acquired on a Siemens mCT Flow PET/CT scanner approximately 60 min after the injection. The coregistered images were displayed and confirmed on a workstation.

Xie Y., Liu C., Zhao Y., Gong C., Li Y., Hu S., Song S., Hu X., Yang Z, & Wang B. (2022). Heterogeneity derived from 18F‐FDG PET/CT predicts immunotherapy outcome for metastatic triple‐negative breast cancer patients. Cancer Medicine, 11(9), 1948-1955.

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Radiosynthesis and Evaluation of 18F-florzolotau

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¹⁸F-florzolotau was prepared in Huashan Hospital using a nucleophilic substitution reaction followed by acid hydrolysis, utilizing with an ¹⁸F-multifunction synthesizer (Beijing PET Technology Co., Ltd., Beijing, China). APRINOIA Therapeutics Co., Ltd (Suzhou, China) provided the tosylate precursor required for the radiosynthesis.
PET images were acquired on a Siemens mCT Flow PET/CT scanner (Siemens, Erlangen, Germany) in 3-dimensional (3D) mode. A low-dose CT transmission scan was performed for attenuation correction. ¹⁸F-florzolotau was administered intravenously (370 MBq). ¹⁸F-florzolotau PET imaging was performed over a 20-minute acquisition time (90–110 minutes). The images were reconstructed using a 3D ordered-subset expectation maximization algorithm (6 iterations; 21 subsets; Gaussian filter, 3.5 mm; zoom, 2). The reconstructed images had a matrix size of 256 × 256 × 148 and an effective voxel size of 1.59 × 1.59 × 1.50 mm.
High-resolution T1-weighted images were acquired in a 3.0-T horizontal magnet (Discovery MR750; GE Medical Systems, Milwaukee, WI) using the following parameters: TE = 3.2 ms, TR = 8.2 ms, TI = 450 ms, flip angle = 12°, acquisition matrix = 256 × 256 × 152, and voxel size = 1 × 1 × 1 mm.

Lu J., Clement C., Hong J., Wang M., Li X., Cavinato L., Yen T.C., Jiao F., Wu P., Wu J., Ge J., Sun Y., Brendel M., Lopes L., Rominger A., Wang J., Liu F., Zuo C., Guan Y., Zhao Q, & Shi K. (2023). Improved interpretation of 18F-florzolotau PET in progressive supranuclear palsy using a normalization-free deep-learning classifier. iScience, 26(8), 107426.

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