Patients received a single injection of 68 Ga-PSMA (mean dose ± standard deviation, 130 ± 11 MBq, range 114–158 MBq) 60 min prior to image acquisition. To reduce tracer activity in the bladder, ureters, and kidneys, furosemide was injected intravenously 30 min prior to the radiotracer injection (0.13 mg/kg), patients drank 200 mL of water prior to radiotracer injection, and patients were asked to void prior to the scan. PET/CT acquisitions were performed on a Discovery VCT 690 PET/CT (GE Healthcare) (n = 38) or on a Discovery MI PET/CT (GE Healthcare) (n = 29) with six-bed positions (2.5 min acquisition time). CT as part of PET/CT was performed using the following scan parameters: tube voltage 140 kVp, tube current with automated dose modulation of 80 mA/slice, collimation 512 × 0.976, pitch 1.0, rotation time 0.5 s, coverage speed 78 mm/s, field of view (FOV) 50 cm. Images with a transverse pixel size of 1.00 and a slice thickness of 1.25 mm were reconstructed in the axial plane using the standard kernel.
Discovery mi pet ct
Manufactured by GE Healthcare
Sourced in United States
The Discovery MI PET/CT is a medical imaging system designed for positron emission tomography (PET) and computed tomography (CT) scans. It combines high-resolution PET and CT imaging capabilities to provide detailed information about the structure and function of the body.
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Lab products found in correlation
Discovery vct 690 pet ct, by GE Healthcare (5 mentions)
Signa pet mr, by GE Healthcare (4 mentions)
Discovery pet ct 690, by GE Healthcare (1 mentions)
Heliodent ds, by Dentsply (1 mentions)
Revolution evo ct system, by GE Healthcare (1 mentions)
Pmod v3, by PMOD Technologies (1 mentions)
Discovery 690 vct, by GE Healthcare (1 mentions)
Lightspeed vct, by GE Healthcare (1 mentions)
17 protocols using discovery mi pet ct
1
Optimized PET/CT Imaging of PSMA
2
FDG-PET/CT and Dental Radiography Protocol
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Detailed FDG-PET/CT acquisition protocols have been reported previously [14 (link), 15 (link)]. In brief, fasting patients with a blood glucose serum concentration below 12 mmol/l were injected with a standardised dose of 18F-FDG, according to our institution’s protocol. After the injection, the patients rested for one hour in supine position in a warm environment. Scanning was performed using integrated PET/CT systems (Discovery MI PET/CT or Discovery PET/CT 690, GE Healthcare, Waukesha, WI, USA).
OPTs were generated in a standing position, with the head oriented to the Frankfurt plane, using a Cranex 3D (Soredex, KaVo, Biberach, Germany). Periapical radiographs were generated using a Heliodent DS (Dentsply-Sirona, Bensheim, Germany) intraoral X-ray, operating at 60 kV and 7 mA. The parallel technique was used with a focus-patient distance of approximately 21 cm.
OPTs were generated in a standing position, with the head oriented to the Frankfurt plane, using a Cranex 3D (Soredex, KaVo, Biberach, Germany). Periapical radiographs were generated using a Heliodent DS (Dentsply-Sirona, Bensheim, Germany) intraoral X-ray, operating at 60 kV and 7 mA. The parallel technique was used with a focus-patient distance of approximately 21 cm.
3
PSMA-11 PET/CT and PET/MR Imaging
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Patients had undergone clinical routine 68Ga-PSMA-11-PET/computed tomography (CT) on a Discovery VCT 690 PET/CT (GE Healthcare, Waukesha, WI, USA) or on a Discovery MI PET/CT (GE Healthcare, Waukesha, WI, USA) or 68Ga-PSMA-11-PET/magnetic resonance (MR) (SIGNA PET/MR, GE Healthcare, Waukesha, WI, USA) after a single injection of 68Ga-PSMA-11 (mean dose ± standard deviation (SD) 130 ± 18 MBq, range 81-171 MBq). The institutional protocol is in agreement with the EANM and SNMMI procedure guidelines 24 . Details are given in the supplements.
4
FDG-PET/CT Protocol for Imaging
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Subjects fasted 6 h prior to the PET study. The patients were injected with 199 ± 4.9 MBq of [18F]FDG intravenously, followed by a rest period of 60 min. Subsequently, patients underwent a 10 min [18F]FDG PET/CT scan in a digital Discovery MI PET/CT (GE Healthcare, Milwaukee, USA) in 3-dimensional mode. The ordered subset expectation maximization (OSEM) algorithm was used for image reconstruction and attenuation correction with CT. The [18F]FDG PET acquisition procedures complied with the European Association of Nuclear Medicine guidelines [17 (link)].
5
PET/CT Scanner Performance Evaluation
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All studies were performed on a Discovery MI PET/CT (GE Healthcare). The system combines a 128-slice computed tomography (CT) system and a 4-ring PET system with LightBurst digital detectors providing a 20-cm axial field-of-view and a 70-cm transaxial field-of-view. The system is TOF-capable with a timing resolution of 377 ps [16 (link)].
6
Dynamic Lung Imaging in ARDS
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High-resolution CT imaging was performed for assessment of regional aeration and strain. After stabilization of ARDSNet or maximal compliance PEEP for 15 min, CT images (GE Discovery MI PET/CT with Revolution EVO CT system, tube current of 49 mAs and voltage of 120 kVp) were acquired dynamically during breathing. Segmentation of global lung volumes was performed semi-automatically with exclusion of large-to-intermediate bronchi and vessels. CT images were reconstructed with standard convolution kernel and filtered back projection resulting in a matrix of 512 × 512 × 112 voxels of 0.977 × 0.977 × 2.5 mm3 [29 (link)].
7
Prostate Cancer Imaging with 68Ga-PSMA-11 PET/CT and PET/MRI
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Patients underwent clinical routine 68Ga-PSMA-11-PET/computed tomography (CT) on a Discovery VCT 690 PET/CT (GE Healthcare, Waukesha, WI, USA) or on a Discovery MI PET/CT (GE Healthcare, Waukesha, WI, USA) or 68Ga-PSMA-11-PET/MRI (SIGNA PET/MR, GE Healthcare, Waukesha, WI, USA) after a single injection of 68Ga-PSMA-11 (mean dose ± standard deviation (SD) 130 ± 18 MBq, range 81–171 MBq). The institutional protocol is in agreement with the EANM and SNMMI procedure guidelines [26 (link)]. Details are given in the supplements.
8
PSMA-1007 PET/CT Guided Biopsy Targeting
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All patients underwent a pelvic PET/CT (two-bed positions) on a dedicated hybrid scanner (Discovery MI PET/CT, GE Healthcare, Waukesha, WI, USA) 60 min after injection of 78 ± 0.9 MBq (77–79) of [18F]PSMA-1007. Details of the imaging protocol are given in the Supplementary materials. For the biopsy-targeting purpose, suspected lesions were delineated on [18F]PSMA-1007 PET/CT by a double-boarded physician (nuclear medicine and radiologist) with 2–3 years of experience in PSMA PET imaging (AM, HG). [18F]PSMA-1007 PET/CT images were fused on PMOD (PMOD v3.8, PMOD-Technologies LLC), through which all CT and reconstructed PET images could be viewed side by side by the reader as well as in fused mode. We used the color scale “rainbow” with a window adapted to allow clear visualization of the target lesion in contrast to the background, thus increasing the conspicuity of suspicious lesions.
9
Ga-PSMA-11 PET/MRI or PET/CT Imaging
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Patients underwent a clinical routine 68Ga-PSMA-11 PET/MRI (SIGNA PET/MR, GE Healthcare, Waukesha, WI, USA) or 68Ga-PSMA-11 PET/CT (Discovery VCT 690 or Discovery MI PET/CT, GE Healthcare, Waukesha, WI, USA). Images were acquired 60 min after injection of 68Ga-PSMA-11 (mean dose ± standard deviation (SD), 131 ± 19 MBq, range 81–160 MBq). To reduce activity in the urinary system, furosemide was injected intravenously 30 min prior to the tracer injection (0.13 mg/kg) and patients were asked to void prior to the scan. The institutional protocol was in agreement with the EANM and SNMMI procedure guidelines [17 (link)]. Studies were reported in clinical routine by experienced dual board-certified radiologists and nuclear medicine physicians, avoiding known PSMA-positive pitfalls [18 (link), 19 (link)]. More details regarding imaging protocol and analysis are given in the supplements.
10
15O-water PET/CT Myocardial Perfusion
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Patients were scanned using a Discovery MI PET/CT (GE Healthcare, Waukesha, WI). The protocol started with a low dose CT scan during normal breathing for attenuation correction. Then 4 min rest and stress scans were perfomed after automated bolus injection of 400 MBq 15O-water according to our clinical standard protocol. Hyperemic MBF was induced using a continuous infusion of adenosine (140 μg·(kg × min)−1) starting 2 min prior to the start of aquisition and continuing throughout the whole scan.
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