A Philips IQon spectral CT scanner was used to scan and enhance the abdomen of CD patients with the following parameters: tube voltage of 120 kV, tube current of 115 mA, slice thickness and slice spacing of 1.0 mm, and field of view (FOV) of 410 mm × 410 mm. Quality control was performed monthly using a Quantitative CT (QCT) body film (Model 4, QCT pro, mindways, United States) and an image analysis system based on the original image of the CT scan body film (Model 4).
Iqon spectral ct scanner
Manufactured by Philips
The IQon Spectral CT scanner is a medical imaging device developed by Philips. It utilizes spectral imaging technology to capture detailed information about the composition of tissues and materials within the body. The scanner is designed to provide high-quality, comprehensive data to support clinical decision-making.
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Lab products found in correlation
7 protocols using iqon spectral ct scanner
1
Spectral CT Imaging of Crohn's Disease
2
Quantifying Tumor Cellularity Using Spectral CT
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Pre-resection CT imaging data were retrieved from the hospital picture archiving system (PACS). All patients underwent contrast enhanced CT in the venous phase (70 s after injection of contrast agent; Ultravist®-370 Bayer, 70 mL, followed by a 30 mL saline chaser) using a Philips IQON Spectral CT scanner (Philips Healthcare, Best, The Netherlands). Conventional, virtual monoenergetic 40 keV images and iodine maps were reconstructed using the philips intellispace portal software (Version 11.1). Histopathological determined regions of different cellularity levels were identified in close collaboration with the responsible pathologist as described above. Corresponding HU values were measured in all images by creating a ROI with diameter approximately 5.0 mm and normalizing it to an equally sized ROI in the aorta (HUTumor/HUAorta). Figure 3 depicts examples of identified regions for low, intermediate and high cellularity level tumor regions in three different patients. MonoE 40 keV CT images are displayed alongside the corresponding histopathology images.
3
Spectral CT Imaging Protocol for Oncology
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All patients underwent a thoraco-abdominopelvic exam on an IQON® Spectral CT scanner (Philips Healthcare, Best, The Netherlands) with a 120 kVp voltage and adapted mAs according to dose modulation. Portal phase images were obtained after intravenous contrast medium (100 mL, Xenetix 350® Guerbet, Villepinte, France) in all patients, except for one with history of serious allergic reaction to iodinated contrast material. One of the patients received positive oral contrast material diluted in mineral water to a concentration of 5% (Telebrix Gastro®, Guerbet, Aulnay-sous-Bois, France). Patients were imaged in the supine position from the pulmonary apex to pelvic symphysis in one spiral acquisition. Radiation dose was evaluated using patient protocols [Mean volume computed tomography dose index (CTDIvol) and Dose length product (DLP)] available in our picture archiving and communication system (PACS, Carestream; Carestream Health, Rochester, New York, NY, USA). The effective dose in millisievert (mSv) was calculated using a “k factor” of 0.015, according to recommendations from International Commission of Radiological protection (ICRP) [12 ].
4
Viscerocranium CT Imaging Protocol
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Each subject received a CT scan of the viscerocranium using either a Siemens Somatom Definition AS + scanner or a Philips IQon Spectral CT scanner. Clinical scan parameters were set according to the clinical routine: collimation, 0.625 mm; pixel spacing, 0.3/0.3 mm; pitch factor, 0.6; tube voltage (peak), 120 kVp; modulated tube current, 102–132 mA. Images were acquired in axial orientation and reformatted in sagittal and coronal orientation using a bone-specific convolution kernel (170H/YB, 3 mm slices).
5
Spectral CT Analysis of Lung Nodules
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Images were obtained by using a Philips IQon spectral CT scanner. All patients were scanned by using the following parameters: tube current, 148–202 mA; collimation thickness, 0.625 mm; helical pitch 1.14; reconstruction thickness 2 mm and the use of Philip iDose4 level-3 iterative reconstruction algorithms. For contrast material-enhanced scanning, an iodinated nonionic contrast agent (Uvexan 300) was injected through the right ulnar vein at 3 mL/s by using an automated injector. The patient was scanned from the oropharynx to the level of the superior edge of the aortic arc. ROI was placed in the aortic arch position, and the scan was automatically triggered. The CT value of the aortic arch reached 150 HU to start the arterial phase, and the arterial phase was scanned for 30s before entering the venous phase. Two radiologists with 10 and 8 years of work experience retrospectively analyzed the imaging data independent of each other, including the longest diameter of the nodule (d ≤ 10 mm, >10 mm), shape (regular or irregular), margin (well or ill defined), area of marginal contact (≤1/4, 1/4 to <1/2 and ≥1/2) (Zhan et al., 2012 (link)), calcification (positive or negative), difference in density between arterial and plain scan, and difference in density between venous and plain scan. When the diagnosis was inconsistent, disagreement was resolved by consensus.
6
Spectral CT Protocol for Dual-Phase Angiography
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All DLCT scans were performed with a Philips IQon Spectral CT scanner (Philips Healthcare, Amsterdam, The Netherlands). The scans included pulmonary CT conventional non-enhanced, and contrast-enhanced scans (both arterial and venous phase). The non-ionic contrast agent (70 mL iopromide; Beijing Beilu Pharmaceutical Co., Ltd., Beijing, China) was administered via an antecubital vein at an intended flow rate of 3.0 mL/s with a high-pressure syringe, followed by 30 mL of saline, injected at the same flow rate. Scans were performed using the bolus chase method. The region of interest (ROI) was located in the descending aorta with a trigger threshold CT number of 150 Hounsfield units (HU). The arterial and venous phases were started 6 and 36 seconds, respectively, after contrast agent injection. The spectral parameters included tube voltage of 120 kVp, spectral CT adaptive current, collimator width of 64 mm × 0.625 mm, pitch of 1.234, 0.27-second rotation time, and a matrix of 512×512. After the scans were completed, the data obtained in the enhanced double-phase were reconstructed by projected spatial spectral reconstruction (Spectral, level 4). The image reconstruction thickness was 1 mm and the image spacing was 1 mm.
7
Dual-Phase CT Angiography Protocol
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The DLCT scans, which comprised both conventional non-enhanced CT and contrast-enhanced CT (cortical and medullary phases), were conducted using IQon spectral CT scanner (Philips Healthcare, Amsterdam, Netherlands).
The contrast agent, iopromide (Bayer Healthcare Company Ltd., Leverkusen, Germany), was administered intravenously via the antecubital vein at a dose of 1.2 mL/kg body weight (80–100 mL) using a high-pressure syringe with an intended flow rate of 3.0 mL/s. The ROI was placed in the abdominal aorta with a trigger threshold of 180 Hounsfield units (HU). Monitoring began after 10 seconds of contrast injection, followed by a 6-second delay for cortical phase scanning after reaching the threshold and medullary phase scanning after 90 seconds of contrast injection. Parameters included tube voltages of 120 kVp, spectral CT adaptive current, collimator width of 64×0.625 mm, pitch of 1.234, 0.27 seconds rotation time, and matrix of 512×512. Following completion of the scans, data obtained from the enhanced dual phases were reconstructed using projected spatial spectral reconstruction (iDose 4). The image reconstruction had a thickness and spacing of 1 mm.
The contrast agent, iopromide (Bayer Healthcare Company Ltd., Leverkusen, Germany), was administered intravenously via the antecubital vein at a dose of 1.2 mL/kg body weight (80–100 mL) using a high-pressure syringe with an intended flow rate of 3.0 mL/s. The ROI was placed in the abdominal aorta with a trigger threshold of 180 Hounsfield units (HU). Monitoring began after 10 seconds of contrast injection, followed by a 6-second delay for cortical phase scanning after reaching the threshold and medullary phase scanning after 90 seconds of contrast injection. Parameters included tube voltages of 120 kVp, spectral CT adaptive current, collimator width of 64×0.625 mm, pitch of 1.234, 0.27 seconds rotation time, and matrix of 512×512. Following completion of the scans, data obtained from the enhanced dual phases were reconstructed using projected spatial spectral reconstruction (iDose 4). The image reconstruction had a thickness and spacing of 1 mm.
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