Benznidazole

Manufactured by Roche

Sourced in Switzerland, Germany

Benznidazole is a laboratory product manufactured by Roche. It is an antiparasitic agent used for in vitro research and development purposes.

Automatically generated - may contain errors

Lab products found in correlation

α ketoisocaproate sodium salt, by Merck Group (2 mentions) N ethylmaleimide, by Merck Group (2 mentions) Pyruvate, by Merck Group (1 mentions) Nifurtimox, by Bayer (1 mentions)

4 protocols using benznidazole

Monoclonal Antibody-Mediated Immune Modulation in Chronic Infection

Check if the same lab product or an alternative is used in the 5 most similar protocols

Blocking or depleting monoclonal antibodies (mAb) were administered by i.p. injection every third day for 30 days with the exception of anti-CD8a which was administered every other day for 21 days. The clone, specificity, and amount administered with each treatment were as follows: anti-IL-10R (1B1.3A) 250 μg; anti-CD8a (YTS 169.4) 200 μg; anti-VLA-4 (PS/2) 150 μg; anti-PD-L1 (MIH5) 200 μg. The anti-CD8a Ab used for detection by flow cytometry is a distinct clone from the depleting Ab used.
Mice were treated with the trypanocidal drug benznidazole (Roche) to reduce the parasite load in chronically infected mice. The compound was administered orally (100 mg/kg body weight) for 21 days.

Pack A.D., Collins M.H., Rosenberg C.S, & Tarleton R.L. (2018). Highly competent, non-exhausted CD8+ T cells continue to tightly control pathogen load throughout chronic Trypanosoma cruzi infection. PLoS Pathogens, 14(11), e1007410.

+ Open protocol

+ Expand

Synthesis and Procurement of Compounds

Cited 1 time

Check if the same lab product or an alternative is used in the 5 most similar protocols

α-ketoisocaproate sodium salt, N-ethylmaleimide and NADH + H⁺ were obtained from Sigma Aldrich (St. Louis, MO, USA). Benznidazole and Nifurtimox were obtained from Roche (Basel, Switzerland) and Bayer (Munich, Germany), respectively. NPOx, B-NPOx and NIPOx were synthesized as previously described [21 (link),22 (link)].

Reséndiz-Mora A., Barrera-Aveleida G., Sotelo-Rodríguez A., Galarce-Sosa I., Nevárez-Lechuga I., Santiago-Hernández J.C., Nogueda-Torres B., Meza-Toledo S., Gómez-Manzo S., Wong-Baeza I., Baeza I, & Wong-Baeza C. (2022). Effect of B-NIPOx in Experimental Trypanosoma cruzi Infection in Mice. International Journal of Molecular Sciences, 24(1), 333.

+ Open protocol

+ Expand

Chagas Disease Therapeutic Compounds

Check if the same lab product or an alternative is used in the 5 most similar protocols

NAD, NADH, pyruvate, α-ketoisocaproate sodium salt and N-ethylmaleimide were obtained from Sigma Chemical Co. (St. Louis, MO, USA). Nifurtimox was purchased from Bayer (Munich, Germany) and benznidazole was from Roche (Basel, Switzerland). NPOx and Et-NPOx were synthesized according to previously reported methods [24 (link)]. All of the chemicals used in the current study were of the highest purity available.

Wong-Baeza C., Nogueda-Torres B., Serna M., Meza-Toledo S., Baeza I, & Wong C. (2015). Trypanocidal effect of the benzyl ester of N-propyl oxamate: a bi-potential prodrug for the treatment of experimental Chagas disease. BMC Pharmacology & Toxicology, 16, 10.

+ Open protocol

+ Expand

Antiparasitic Drug Treatment in Mice

Check if the same lab product or an alternative is used in the 5 most similar protocols

For drug treatment, benznidazole (Hoffmann-La Roche AG) was prepared from powder at 10 mg/ml in 7% Tween 80, 3% ethanol (vol/vol), and 90% (vol/vol) water. Posaconazole (Sequoia Research Products, Ltd.) was prepared at 2 mg/ml in 5% (vol/vol) dimethyl sulfoxide and 95% (vol/vol) HPMC-SV (0.5% [wt/vol] hydroxypropyl methylcellulose, 0.5% [vol/vol] benzyl alcohol and 0.4% [vol/vol] Tween 80). Noxafil (MSD, Ltd.), a liquid formulation of posaconazole (40 mg/ml), was diluted to 2 mg/ml in water. Mice were treated with standard doses of benznidazole (100 mg/kg/day) or posaconazole (20 mg/kg/day) by oral gavage for consecutive days, as required. To facilitate the detection of residual infection after treatment, BALB/c mice were immunosuppressed in some experiments with cyclophosphamide (200 mg/kg) by i.p. injection at 3- to 4-day intervals, for a maximum of three doses.

Francisco A.F., Lewis M.D., Jayawardhana S., Taylor M.C., Chatelain E, & Kelly J.M. (2015). Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging. Antimicrobial Agents and Chemotherapy, 59(8), 4653-4661.

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!