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αifnar mar1 5a3

Manufactured by BioXCell
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The αIFNAR; MAR1-5A3 is a monoclonal antibody that binds to the interferon alpha/beta receptor (IFNAR). It is a lab equipment product used in research applications.

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Lab products found in correlation

Igg1 mopc 21, by BioXCell (1 mentions) Brefeldin a, by InvivoGen (1 mentions) α ly 6g 1a8, by BioLegend (1 mentions) αcd4 gk1, by BioXCell (1 mentions)

Spelling variants of this product

MAR1-5A3 (25 citations) αIFNAR antibody (MAR1–5A3; (2 citations)

2 protocols using αifnar mar1 5a3

1

Modulating IFN Receptor for Poly(I:C) Response

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On E13.5, pregnant females were i.v. injected with a single dose of 400 µg anti-IFN receptor 1 (αIFNAR; MAR1-5A3 [60 (link)], Bio X Cell, NH, USA) or control IgG (IgG1; MOPC-21, Bio X Cell, NH, USA) in 150 µl PBS. After 1 day, on E14.5, the treated females were injected with poly(I:C) or PBS, as described above.
Ben-Yehuda H., Matcovitch-Natan O., Kertser A., Spinrad A., Prinz M., Amit I, & Schwartz M. (2019). Maternal Type-I interferon signaling adversely affects the microglia and the behavior of the offspring accompanied by increased sensitivity to stress. Molecular Psychiatry, 25(5), 1050-1067.
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2

Blocking Antibodies Enhance Influenza Immunity

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For blocking antibodies, mice were injected i.p. with 250µg of α−CD4 (GK1.5, BioXcell) or 200µg of α-IFNAR (MAR1.5A3, BioXCell) one day before receiving 100 PFU of BrightFlu followed by a second dose at day 4 post infection. For depleting antibodies, mice were injected i.p. with 250µg of α-Ly-6G (1A8, Biolegend) daily for 5 days starting from 1 day prior to BrightFlu. Poly(I:C) was injected intratumorally with 10µg of Poly(I:C)-Rhodamine in 10µl PBS. For intracellular IL-12 staining, mice were injected i.v. with 250µg of Brefeldin A (Invivogen) and tissues harvested 6hr post injection.
Pirillo C., Al Khalidi S., Sims A., Devlin R., Zhao H., Pinto R., Jasim S., Shearer P., Shergold A., Donnelly H., Bravo-Blas A., Loney C., Perona-Wright G., Hutchinson E, & Roberts E. (2023). Co-transfer of antigen and contextual information harmonises peripheral and lymph node cDC activation. Science immunology, 8(85), eadg8249.
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