The active substance used was cetirizine dihydrochloride (Jubilant Lifesciences Ltd, India; CTZ). The excipients used for the study SeDeM were talc (Fagron, Spain), magnesium stearate (Fagron, Spain), and colloidal silicon dioxide (Aerosil ®, Fagron, Spain). The excipients used in the factorial design were mannitol (Fagron, Spain) and polyvinylpyrrolidone Ph. Eur (Fagron, Spain). The reagents used for the preparation of phosphate buffers solutions (solubility studies) were: 37% HCl (Panreac, Barcelona), NaCl (Panreac, Barcelona), NaOH (Panreac, Barcelona) and KH2PO4 (Panreac, BCN).
Aerosil
Manufactured by Fagron
Sourced in Spain
Aerosil is a fumed silica product manufactured by Fagron. It is a fine, white, amorphous powder that is used as a thickening, suspending, and anti-caking agent in various applications.
Automatically generated - may contain errors
2 protocols using aerosil
1
Cetirizine Formulation Development and Evaluation
2
Carbamazepine Formulation Development
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The active pharmaceutical ingredient (API) used was carbamazepine (batches: 16CT000089 and 16CT000017), obtained from CTX Lifesciences Pvt. Limited, India.
The main excipients used were:l -HPC LH11 [(low-substituted hydroxypropylcellulose) (supplier: SHINETSU, Tokyo, Japan)]; l -HPC NBD022 [(low substituted hydroxypropyl cellulose) (supplier: SHINETSU, Tokyo, Japan)].
The adjuvant excipients used were: VIVASOL GF® [(croscarmellose) (batch: 7111601027, supplier: JRS PHARMA, Rosenberg, Germany)]; VIVAPHARM PVP PXL® [(crospovidone type A) (supplier: JRS PHARMA, Rosenberg, Germany)]; VIVAPHARM PVP PXL10® [(Crospovidone Type B) (supplier: JRS PHARMA, Rosenberg, Germany)]; PEARLITOL 200 SD® [(d -Mannitol) (supplier: ROQUETTE LAISA ESPAÑA, Valencia, Spain)]. The excipients used as lubricants and ligants were: Talc (supplier: Fagron, Barcelona, Spain); magnesium stearate (supplier: Fagron, Barcelona, Spain) and colloidal silicon dioxide (Aerosil®) (supplier: Fagron, Barcelona, Spain) as a standard lubrication blend. All components were stored at room temperature (20–30 °C).
The main excipients used were:
The adjuvant excipients used were: VIVASOL GF® [(croscarmellose) (batch: 7111601027, supplier: JRS PHARMA, Rosenberg, Germany)]; VIVAPHARM PVP PXL® [(crospovidone type A) (supplier: JRS PHARMA, Rosenberg, Germany)]; VIVAPHARM PVP PXL10® [(Crospovidone Type B) (supplier: JRS PHARMA, Rosenberg, Germany)]; PEARLITOL 200 SD® [(
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