Suvorexant

Manufactured by Adooq

Suvorexant is a laboratory instrument designed for the analysis and detection of chemical compounds. It operates by utilizing the principles of orexin receptor antagonism to identify and measure the presence of specific target analytes in research samples. The core functionality of Suvorexant is to provide accurate and reliable data for scientific investigations, without making interpretations or extrapolations about its intended use.

Automatically generated - may contain errors

Lab products found in correlation

2 protocols using suvorexant

Oleuropein and Suvorexant Evaluation in Rat CCI Model

Check if the same lab product or an alternative is used in the 5 most similar protocols

For this study, male Wistar rats (200-250 g) were used. The Institutional Animals Ethics Committee of Yidu Central Hospital of Weifang approved the experimental protocol (approval number: 201900876B097). Suvorexant was purchased from AdooQ BioScience, Irvine, CA; oleuropein and dimethyl sulfoxide (DMSO) were purchased from Sigma-Aldrich, St. Louis, MO. The doses of Suvorexant (10 and 20 mg/kg) [24 (link)] and oleuropein (10 and 20 mg/kg) [25 (link)] were selected on the basis of previously published literature. Suvorexant was dissolved in 10% DMSO, and oleuropein was dissolved in water. Vincristine sulfate was dissolved in normal saline. The drugs oleuropein and Suvorexant were administered to CCI, vincristine, and non-treated rats daily, by the oral route. The oral route was chosen to avoid the pain induction that may arise due to a daily injection of drugs. Since the direct administration of drugs by the oral route may also produce stress, drugs were administered by dissolving them in drinking water. To avoid variation in drinking water, drugs were dissolved in a specific volume of drinking water (200 mL of), and care was taken so that animals consumed the entire 200 mL of water.

Chen H., Ma D., Zhang H., Tang Y., Wang J., Li R., Wen W, & Zhang Y. (2021). Antinociceptive effects of oleuropein in experimental models of neuropathic pain in male rats. The Korean Journal of Pain, 34(1), 35-46.

+ Open protocol

+ Expand

Midazolam Metabolism and CYP3A Inhibition

Check if the same lab product or an alternative is used in the 5 most similar protocols

Midazolam was purchased from Wako Pure Chemical Industries (Osaka, Japan). The metabolite of Midazolam, 19-hydroxyMidazolam, was purchased from Sigma-Aldrich (St. Louis, MO). As an internal standard, 13 C-19-hydroxyMidazolam was obtained from Corning (Corning, NY). The following marketed drugs were used for the evaluation of the potential to inhibit or induce CYP3A: atomoxetine hydrochloride (Tokyo Chemical Industry, Tokyo, Japan), atorvastatin (LKT Laboratories, St. Paul, MN), azithromycin dehydrate (LKT Laboratories), casopitant mesylate (Santa Cruz Biotechnology, Dallas, TX), cimetidine (Sigma-Aldrich), deferasirox (Toronto Research Chemicals, North York, Canada), ethinyl estradiol (Sigma-Aldrich), everolimus (Selleck Chemicals, Houston, TX), felodipine (Sigma-Aldrich), fluoxetine (Sigma-Aldrich), fluvoxamine (Sigma-Aldrich), pazopanib (ChemieTek, Indianapolis, IN), ranitidine hydrochloride (Sigma-Aldrich), roxithromycin (Sigma-Aldrich), simvastatin (Wako Pure Chemical), suvorexant (AdooQ-BioScience, Irvine, CA), and tadalafil (Selleck Chemicals). Pooled human microsomes (mixed sex, 20 mg protein/ml) and pooled cryopreserved human hepatocytes were purchased from Sekisui XenoTech, LLC (Kansas City, KS). NADPH Regeneration System Solution A and NADPH Regeneration System Solution B were purchased from Corning.

Yamada M., Inoue S.I., Sugiyama D., Nishiya Y., Ishizuka T., Watanabe A., Watanabe K., Yamashita S, & Watanabe N. (2020). Critical Impact of Drug-Drug Interactions via Intestinal CYP3A in the Risk Assessment of Weak Perpetrators Using Physiologically Based Pharmacokinetic Models. Drug metabolism and disposition: the biological fate of chemicals, 48(4).

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!