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4 protocols using lauroglycol

1

Solubilization of Micronized Compound I

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Example 4

Micronized Compound I was weighed into a vial (1.8 mg) and propylenglycol monolaurate [Lauroglycol FCC from Gattefossé] was added (100 μL). The sample was agitated by vortex at room temperature. No clear solution was obtained. More proplenglycol monolaurate was added in portions (2×100 μL) and a clear solution was obtained after agitation by vortex.

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2

Formulation and Evaluation of Curcumin Nanoparticles

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CUR was purchased from India (purity of 95%). Standard CUR was obtained from the Vietnam Institute of Quality control (99.56%). Capryol 90, Labrafil, Labrasol, and Lauroglycol were obtained from Gattefossé (Paris, France). All other chemicals were of analytical grade. A commercial gel (containing nanosized CUR) is a marketed product, which was purchased at a pharmacy in Vietnam.
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3

Formulation Development of LCZ Nanoemulsion

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LCZ was purchased from Macklin Biochemical Co., Ltd. (Shanghai, China); oleic acid was obtained from Tokyo Chemical Industries Co., Ltd. (Tokyo, Japan); propylene glycol dicaprylate (PGD) and castor oil were obtained from Hunan Erkang Pharmaceutical Co., Ltd. (Hunan Province, Changsha, China); Cremophor® RH (RH40), Cremophor® EL35 (EL35) and Kolliphor® HS15 (HS15) were obtained from BASF SE (Ludwigshafen, Germany); Tween 80 was obtained from Jinshan Pharmaceutical Co., Ltd. (Sichuan Province, Meishan, China); polyethylene glycol 400 (PEG400) was purchased from Solarbio Life Science (Beijing, China); Capryol 90, Lauroglycol™ FCC, Lauroglycol and Transcutol® P were received as gifts from Gattefosse (Lyon, France). Methanol and acetonitrile (HPLC grade) were obtained from Merck (Darmstadt, Germany) and Tedia (Fairfield, OH, USA), respectively. Other reagents (analytical grade) were purchased from commercial suppliers.
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4

Isoniazid-Rifampicin Delivery Protocol

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Isoniazid was obtained from Avra, rifampicin, resveratrol, Kolliphor, Methanol, Di-methyl sulfoxide and Castor oil were obtained from Sigma Ltd, India. Lauroglycol, Transcutol, Labrafil M, Capryol 90 were obtained as gift samples from Gattefosse. Ethanol, Oleic acid, Isopropyl myristate, Tween 80 and potassium chloride were purchased from Avra. All the chemicals obtained were pure and were of laboratory grade.
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