Fluorinert fc 770

Manufactured by 3M

Sourced in Sao Tome and Principe

Fluorinert FC-770 is a clear, colorless, and odorless fluorinated liquid produced by 3M. It has a boiling point of 97°C and is non-flammable. The product is designed for use as a heat transfer fluid in laboratory and industrial applications.

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Lab products found in correlation

Bpx 30, by Bayer (2 mentions) Achieva, by Philips (1 mentions) Lidocaine, by Akorn (1 mentions) Invivo, by Philips (1 mentions) Achieva tx, by Philips (1 mentions) Lsm 700, by Zeiss (1 mentions) Texas red dextran, by Thermo Fisher Scientific (1 mentions)

Close spelling variants of this product

Fluorinert (26 citations) FC-770 (6 citations)

4 protocols using fluorinert fc 770

Multiparametric MRI Protocol for Prostate Cancer

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MRI studies were performed using an endorectal (BPX-30, Medrad, Pittsburgh, PA) and a 16-channel anterior cardiac coil (SENSE, Philips Medical Systems, Best, The Netherlands) on a 3 T magnet (Achieva, Philips Medical Systems, Best, the Netherlands) without prior bowel preparation. The endorectal coil was inserted using a semi-anesthetic gel (Lidocaine, Akorn Inc., Lake Forest, IL) while the patient was in the left lateral decubitus position. The balloon surrounding the coil was distended with perfluorocarbon (Fluorinert FC-770, 3 M, St. Paul, MN) to a volume of approximately 45 mL. The MRI protocol included tri-planar T2 W turbo spin echo (TSE), diffusion weighted (DW) MRI (ADC maps and b2000 DW MRI), axial pre-contrast T1 W, axial 3D T1-weighted fast field echo dynamic contrast-enhanced MRI (DCE MRI) sequences [16 (link)].

Mena E., Lindenberg M.L., Shih J.H., Adler S., Harmon S., Bergvall E., Citrin D., Dahut W., Ton A.T., McKinney Y., Weaver J., Eclarinal P., Forest A., Afari G., Bhattacharyya S., Mease R.C., Merino M.J., Pinto P., Wood B.J., Jacobs P., Pomper M.G., Choyke P.L, & Turkbey B. (2017). Clinical impact of PSMA-based 18F—DCFBC PET/CT imaging in patients with biochemically recurrent prostate cancer after primary local therapy. European journal of nuclear medicine and molecular imaging, 45(1), 4-11.

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Multiparametric MRI of Prostate Cancer

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Multi-parametric MRI of the prostate is performed on a 3-Tesla MR scanner (Achieva-TX, Philips Healthcare, Best, NL) using the anterior half of a 32-channel SENSE cardiac coil (In Vivo, Philips Healthcare, Gainesville FL, USA) and an endorectal coil (BPX-30, Medrad, Indianola PA, USA). No pre-examination bowel preparation was required. The balloon of each endorectal coil is distended with approximately 45 mL of perfluorocarbon (Fluorinert FC-770, 3M, St Paul, MN, USA) to reduce imaging artifacts related to air-induced susceptibility. T2-weighted (T2W) MRI and diffusion-weighted MRI (DWI) are acquired. T2W MRI has a resolution of 0.27mm × 0.27mm. The standard DWI is acquired with 5 evenly-spaced b-values (0–750 s/mm²), and a map of the apparent diffusion coefficient (ADC) is calculated per voxel. Multi-parametric MRI is independently evaluated by three experienced genitourinary radiologists (SS, BT, and PLC with 2, 7 and 14 years of experience). The whole prostate, peripheral zone, transition zone, and cancer lesions are delineated and recorded in an MRI coordinate system. The whole prostate is first automatedly segmented by research software (iCAD Inc., Nashua, NH, USA) and the resulting segmentation is manually adjusted by the radiologists. DWI images are rigidly registered with T2W MRI images using MR coordinate information [16 ]. The registration is performed per MR slice.

Kwak J.T., Sankineni S., Xu S., Turkbey B., Choyke P.L., Pinto P.A., Merino M, & Wood B.J. (2015). Correlation of Magnetic Resonance Imaging with Digital Histopathology in Prostate. International journal of computer assisted radiology and surgery, 11(4), 657-666.

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Measuring Airway Surface Liquid Thickness in HNE Cells

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The thickness of the ASL was measured in HNE cells using a modified version of the method described by Terran et al. (Tarran et al. 2005 (link)). Briefly, the cells were washed, and 20 μL of PBS containing 0.2% (v/v) Texas Red-dextran (Invitrogen) was added onto the apical cell surface to label the ASL layer. A 100-μL aliquot of perfluorocarbon (Fluorinert FC-770; 3M, St. Paul, MN) was then added to the apical surface to prevent evaporation of the ASL. After 12 h, the cultures were transferred to the stage of an inverted confocal microscope (LSM 700; Carl Zeiss MicroImaging Inc., Thornwood, NY) and the height of the ASL was measured at five predetermined points in the cultures (one central, four circumferential) via XZ scans. Images were reconstructed three dimensionally and analyzed using Imaris 7.1 software (Bitplane Co, Zurich, Switzerland).

Lee H.J., Yoo J.E., Namkung W., Cho H.J., Kim K., Kang J.W., Yoon J.H, & Choi J.Y. (2015). Thick airway surface liquid volume and weak mucin expression in pendrin-deficient human airway epithelia. Physiological Reports, 3(8), e12480.

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Ex Vivo Mouse Brain MRI Imaging

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Animal experiments were preapproved by the Weizmann Institute's IACUC, which is fully accredited by the AAALAC, the US NIH Office of Laboratory Animal Welfare and the Israel Ministry of Health. Healthy male C57BL/6 mice aged ~6 months were used in the study, both for the in vivo (n = 4) and ex vivo (n = 4) experiments (with different mice used for the in vivo and ex vivo experiments). For the ex vivo experiments, the animals were sacrificed by cervical dislocation; their brains were then removed, and carefully submerged in their entirety in Fluorinert FC‐770 (3 M, Zwijndrecht, Belgium), a proton‐free fluid that minimizes susceptibility artifacts and has little impact on a tissue's histochemical properties.³², ³³ Such immersed brains were placed—without fixation—inside 5‐mm Shigemi tubes (Wilmad Labglass, Vineland, NJ, USA), for the purpose of improving the field homogeneity over our small specimens. Experiments were only performed within the first 8 h postremoval of the brains to avoid, in as much as possible, sample decomposition.

Martinho R.P., Jain M.G, & Frydman L. (2022). High‐field ex vivo and in vivo two‐dimensional nuclear magnetic resonance spectroscopy in murine brain: Resolving and exploring the molecular environment. Nmr in Biomedicine, 36(2), e4833.

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