This prospective study included patients up to 16 years of age, who were referred for ultrasound evaluation of suspected appendicitis or undifferentiated right iliac fossa pain, between December 2015 and April 2017 in an Australian tertiary children’s hospital. A sample size was of 138 patients was required to achieve a sensitivity of at least 90%, with 80% power (ß) and α<0.05 [15 (link)]. This was adjusted to 230 patients, as we estimated a 50% improvement in the visualization rate (to 60%) due to the training provided as part of the study, compared to the 40% visualization rate of our prior study in the same population [16 ]. Changes in the value of ultrasound examinations between the current and prior study were evaluated through a comparison of diagnostic accuracy calculations, primarily the change in the likelihood ratio, which would alter the post-test probability and therefore the value of the examination for a referring clinician. Examinations performed after-hours were not included in the study to limit costs through overtime. Children's Health Queensland Human Research and Ethics Committee approval was obtained (HREC/15/QRCH/125). Written informed consent was provided by the parent or guardian of all children enrolled. All examinations were performed using a Philips Epiq 7G ultrasound platform (Philips Healthcare, Bothwell, WA, USA).
Epiq 7g
Manufactured by Philips
Sourced in United States, Japan
The Epiq 7G is a high-performance ultrasound system designed for comprehensive imaging. It features advanced imaging technologies to provide detailed visualization of anatomical structures. The system is capable of generating high-quality images to support clinical decision-making.
Automatically generated - may contain errors
Lab products found in correlation
Aplio 500, by Canon (3 mentions)
Aplio 500, by Toshiba (3 mentions)
Ie33 xmatrix, by Philips (2 mentions)
X6 1 transducer, by Philips (2 mentions)
3 8 mhz sector ultrasound transducer, by Philips (1 mentions)
Intellispace cardiovascular ultrasound viewer, by Philips (1 mentions)
Logiq e9, by GE Healthcare (1 mentions)
Qlab workstation, by Philips (1 mentions)
Mit elite plus, by Omron (1 mentions)
Somatom force scanner, by Siemens (1 mentions)
Affiniti 70, by Philips (1 mentions)
C5 1 probe, by Philips (1 mentions)
Stata 16, by StataCorp (1 mentions)
Echopac software version 112, by GE Healthcare (1 mentions)
Aplio 400, by Canon (1 mentions)
40 protocols using epiq 7g
1
Pediatric Appendicitis Ultrasound Accuracy
2
Echocardiographic Assessment Protocol
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Echocardiographic assessment was performed for all study participants by one investigator. Echocardiographic images were acquired using a Philips iE33 xMatrix or a Philips Epiq 7G ultrasound device (Philips Healthcare, Amsterdam, The Netherlands) with a 1–5 MHz or a 3–8 MHz sector ultrasound transducer (Philips Healthcare, Amsterdam, The Netherlands). Echocardiography was performed under constant three-lead ECG tracking. Three consecutive loops were recorded and transferred to an offline workstation for further analysis (IntelliSpace Cardiovascular Ultrasound Viewer, Philips Healthcare, Amsterdam, the Netherlands). The echocardiographic offline analysis was performed by one investigator for all study participants.
3
Echocardiographic Assessment of Aortic Valve
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Echocardiographic studies were performed using Vivid S70 (GE Vingmed Ultrasound, Horton, Norway; transducer M5Sc-D, 1.4–4.6 MHz), Vivid-E9 (GE Vingmed Ultrasound, Horton, Norway; transducer M5S-D, 1.4–4.6 MHz) and Philips EPIQ 7G (Philips Medical Systems, Andover, MA, USA; transducer X5-1, 1–5 MHz) ultrasound machines and stored in the Institutional Data Repository. All echocardiographic studies were conducted by experienced clinicians. Image analysis and all measurements were carried out according to the current guidelines [11 (link), 17 (link)]. At the time of recording, maximum efforts were made to obtain optimal aortic valve images using zoom mode in most cases and manual adjustments of the gain and dynamic range according to the recommendations [18 (link)]. Two-dimensional images in the parasternal long-axis view, parasternal short-axis view, as well as three- and five-chamber apical views of the left ventricle (LV) focused on the AV were recorded in standard Grey scale using harmonic imaging mode and stored for most studies.
4
Carotid Artery Ultrasound Examination
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Sonography of both common carotid arteries (CCA) was performed by one investigator for all study participants using either a Philips iE33 xMatrix or a Philips Epiq 7G ultrasound device (Philips Healthcare, Amsterdam, The Netherlands). During the examination, study participants were asked to remain in a supine position, and the neck was extended to a 45° angle and turned to the opposite side of examination [22 (link)]. Offline analysis was conducted by one investigator.
5
Echocardiographic Evaluation of Ventricular Volumes
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Echocardiographic examinations were performed using iE33 (Philips Medical Systems, Andover, MA, USA; Cardiocentro Ticino) and Epiq 7G (Philips Ultrasound, Inc, Reedsville, PA, USA; Medical University of Silesia) ultrasound systems. Patients were evaluated in the left lateral decubitus position and images acquired from standard parasternal, suprasternal, and apical windows. Data were digitally recorded and analysed offline by a single observer for the two centres. Left-ventricular end-systolic and end-diastolic volumes, and ejection fraction were obtained using the modified biplane Simpson method.
6
Laryngeal Ultrasound Diagnosis of VCD
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LUS was performed by 3 pediatric sonographers using a Philips Epiq 7G platform (Philips Healthcare). Static images were recorded with the cords abducted (Figure 2 , A) and adducted (Figure 2 , B). Cine-loops were recorded for review by a single consultant radiologist.![]()
Static images demonstrating cords abducted (A) and cords adducted (B) on laryngeal ultrasound.
7
Transthoracic Echocardiography and Cardiac Output Measurement
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Click or tap here to enter text. Transthoracic echocardiography (EPIQ 7G, Philips, Netherlands) was performed in Part A and Part B before ischemia operation, gene transfer, and sacrifice to measure any detectable pericardial fluid. Cardiac output was measured by LV cine imaging at rest and under dobutamine-induced stress at increasing infusion rates. Upon reaching the target heart rate of 160 bpm, the infusion rate was kept constant during fluoroscopic imaging. Before the operations, pigs were sedated with an intramuscular injection of 1.5 mL atropine and 6 mL of azaperone. After the sedation, animals were kept under anesthesia with propofol (15 mg/kg/h) and fentanyl (10 μg/kg/h).
8
Thyroid Nodule Ultrasonographic Evaluation
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Each nodule was evaluated using the LOGIQ E9 (GE Healthcare, Milwaukee, WI, USA) with both 9 MHz linear transducer and 1 to 5 MHz curvilinear transducer or the EPIQ 7G (Philips Healthcare, Cleveland, OH, USA) with both 12 to 15 MHz linear transducer and 1 to 5 MHz curvilinear transducer. B-mode and color duplex Doppler imaging was conducted using the 12 to 15 MHz linear transducer, while elastography was performed using the 9 MHz linear transducer. The examinations were performed by two physicians with over 10 years of experiences. The imaging findings that were evaluated included the nodule dimensions, ratio of the anteroposterior diameter to the transverse diameter, nodule echogenicity, peripheral halo, and calcification.
9
Liraglutide's Impact on Metabolic Parameters
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In order to assess the improvement in clinical parameters, we performed an overnight fasting metabolic profile at baseline and at 4 months and 10 months of liraglutide for glucose, hemoglobin A1c (HbA1c), insulin, high‐sensitivity C‐reactive protein (hsCRP), and lipids (low‐density lipoprotein [LDL] cholesterol, high‐density lipoprotein [HDL] cholesterol, and triglycerides). Standard biological assays were performed in accredited clinical chemistry laboratories in Switzerland. Homeostatic model assessment of insulin resistance (HOMA‐IR) was calculated as glycemia (mmol/L) × insulin (U/L)/22.5 [23 (link)]. Dyslipidemia was defined as the presence of one or more abnormal plasma lipid concentrations (LDL cholesterol > 3 mmol/L, triglycerides > 2.3 mmol/L) or use of statins [24 (link)]. Prediabetes was diagnosed based on HbA1c (5.7%–6.5%) or fasting glycemia (5.6–6.9 mmol/L).
To assess the effect of liraglutide on nonalcoholic fat liver disease (NAFLD), hepatic tests (aspartate transaminase, alanine transaminase, γ‐glutamyl transferase, alkaline phosphatase, platelets, albumin) and liver ultrasound (Philips, Epiq 7G) were performed before and after 10 months of treatment. NAFLD fibrosis score was calculated as previously described [25 (link)].
To assess the effect of liraglutide on nonalcoholic fat liver disease (NAFLD), hepatic tests (aspartate transaminase, alanine transaminase, γ‐glutamyl transferase, alkaline phosphatase, platelets, albumin) and liver ultrasound (Philips, Epiq 7G) were performed before and after 10 months of treatment. NAFLD fibrosis score was calculated as previously described [25 (link)].
10
Echocardiographic Evaluation of Sib-Pair Dogs
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For the echocardiographic examinations of the sib-pair (GR01 and GR02, at an age of 6 years and 1 month), the dogs were placed in right and then left lateral recumbency on an ultrasound examination table. The echocardiographic evaluation was conducted by use of an ultrasonographic unit (EPIQ 7G, Philips Ultrasound, Bothell, WA, USA) equipped with a 5-1 matrix transducer and ECG monitoring. The heart was examined and subjectively assessed in standard right- and left-sided views [29 (link)]. Blood flow over heart valves was interrogated using color mode Doppler echocardiography and measured using spectral Doppler echocardiography. Left ventricular dimensions were measured using M-mode echocardiography in the right parasternal short axis view at the level of the papillary muscles. The left atrial diameter was measured in the right parasternal short axis view at the level of the aortic valve. Left ventricular dimensions were compared to published weight-based normal reference ranges [30 (link)] and left atrial diameter was indexed to the aortic diameter as previously described [31 (link)].
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