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Liaison direct renin kit

Manufactured by DiaSorin
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Sourced in Italy

The LIAISON Direct Renin kit is a laboratory equipment product manufactured by DiaSorin. It is used for the quantitative determination of renin in human serum and plasma samples. The kit utilizes a chemiluminescent immunoassay technology to measure renin levels.

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Lab products found in correlation

Liaison aldosterone kit, by DiaSorin (5 mentions) Aldoctk 2, by DiaSorin (1 mentions)

6 protocols using liaison direct renin kit

1

Plasma Renin and Aldosterone Measurement

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Plasma renin concentration (PRC) and plasma aldosterone concentration were measured by chemiluminescence immunoassay using the LIAISON Direct Renin kit (DiaSorin S.p.A, Vercelli, Italy) and the LIAISON Aldosterone kit (DiaSorin Inc., Stillwater, MN, USA). Plasma was collected from patients after 2 hours of upright position for measuring PRC and plasma aldosterone concentration.
Fan P., Pan X.C., Zhang D., Yang K.Q., Zhang Y., Tian T., Luo F., Ma W.J., Liu Y.X., Wang L.P., Zhang H.M., Song L., Cai J, & Zhou X.L. (2020). Pediatric Liddle Syndrome Caused by a Novel SCNN1G Variant in a Chinese Family and Characterized by Early-Onset Hypertension. American Journal of Hypertension, 33(7), 670-675.
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2

Plasma Renin and Aldosterone Measurement

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The plasma renin concentration and plasma aldosterone concentration (PAC) were measured by chemiluminescence immunoassay using the LIAISON® direct renin kit (DiaSorin S.p.A, Vercelli, Italy) and the LIAISON® aldosterone kit (DiaSorin Inc., Stillwater, MN, USA). Other biochemical examinations were performed using standard protocols.
Fan P., Lu Y.T., Yang K.Q., Zhang D., Liu X.Y., Tian T., Luo F., Wang L.P., Ma W.J., Liu Y.X., Zhang H.M., Song L., Cai J., Lou Y, & Zhou X.L. (2020). Apparent mineralocorticoid excess caused by novel compound heterozygous mutations in HSD11B2 and characterized by early-onset hypertension and hypokalemia. Endocrine, 70(3), 607-615.
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3

Aldosterone and Renin Measurement

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Blood samples were centrifuged and tested immediately after collection. PRA and PACRIA were measured by RIA with the RENCTK RIA kit (DiaSorin, Saluggia, Italy) and ALDOCTK-2 (DiaSorin, Saluggia, Italy) according to the manufacturer's instructions. DRC and PACCLIA were detected by CLIA using the LIAISON® Direct Renin kit (DiaSorin, Saluggia, Italy) and the LIAISON® XL Aldosterone kit on the corresponding fully automated analyzer (DiaSorin, Saluggia, Italy) according to the manufacturer's protocol. The equations of ARR and ADRR are as follows: ARR= PRA/PACRIA; ADRR=DRC/  PACCLIA.
Li T., Ma Y., Zhang Y., Liu Y., Fu T., Zhang R., Kang K., Yang Y., Wang L., Jiang Y, & Lu Y. (2019). Feasibility of Screening Primary Aldosteronism by Aldosterone-to-Direct Renin Concentration Ratio Derived from Chemiluminescent Immunoassay Measurement: Diagnostic Accuracy and Cutoff Value. International Journal of Hypertension, 2019, 2195796.
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4

Comprehensive Diagnostic Evaluation for Adrenal Disorders

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Imaging examinations were performed during the proband’s hospitalization, including echocardiography, abdomen ultrasound and CT of the kidneys, adrenal glands and renal arteries. Biochemical evaluations performed included urine protein, microalbuminuria, adrenocorticotropin and serum cortisol on different occasions. Plasma renin concentration (PRC) and PAC were measured for all the participants at Fuwai Hospital by a chemiluminescence immunoassay using the LIAISON Direct Renin kit (DiaSorin S.p.A, Vercelli, Italy) and the LIAISON Aldosterone kit (DiaSorin Inc., Stillwater, USA). The other biochemical examinations were measured using standard methods.
Fan P., Lu C.X., Zhang D., Yang K.Q., Lu P.P., Zhang Y., Meng X., Hao S.F., Luo F., Liu Y.X., Zhang H.M., Song L., Cai J., Zhang X, & Zhou X.L. (2018). Liddle syndrome misdiagnosed as primary aldosteronism resulting from a novel frameshift mutation of SCNN1B. Endocrine Connections, 7(12), 1528-1534.
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5

Adrenal and Renal Imaging Protocol

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Computed tomography of the kidneys, adrenal glands, and renal arteries and echocardiography were performed on the proband. PRC and PAC were measured in 8 subjects (Table 1) after they had remained in an upright position for 2 h. PRC and PAC were measured by chemiluminescence immunoassay using a LIAISON Direct Renin kit (DiaSorin S.p.A, Vercelli, Italy) and a LIAISON Aldosterone kit (DiaSorin Inc., Stillwater, MN, USA), respectively. Other biochemical measurements were made using standard methods.
Fan P., Zhang D., Pan X.C., Yang K.Q., Zhang Q.Y., Lu Y.T., Zhang Y., Liu X.Y., Ma W.J., Zhang H.M., Song L., Cai J., Liu Y.X, & Zhou X.L. (2020). Premature Stroke Secondary to Severe Hypertension Results from Liddle Syndrome Caused by a Novel SCNN1B Mutation. Kidney & blood pressure research, 45(4).
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6

Comprehensive Hypertension Evaluation

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Imaging examinations were performed including echocardiography, abdomen ultrasound, and computed tomography (CT) of the kidneys, adrenal glands, and renal arteries. Laboratory testing covered general biochemical measurements associated with hypertension, such as serum electrolytes, urine protein, microalbuminuria, and blood gas analysis. PRC and PAC were measured at Fuwai Hospital by means of a chemiluminescence immunoassay using the LIAISON Direct Renin kit (DiaSorin S.p.A, Vercelli, Italy) and the LIAISON Aldosterone kit (DiaSorin Inc., Stillwater).
Fan P., Zhao Y.M., Zhang D., Liao Y., Yang K.Q., Tian T., Lou Y., Luo F., Ma W.J., Zhang H.M., Song L., Cai J., Liu Y.X, & Zhou X.L. (2019). A Novel Frameshift Mutation of SCNN1G Causing Liddle Syndrome with Normokalemia. American Journal of Hypertension, 32(8), 752-758.
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