Explotab

Manufactured by JRS Pharma

Sourced in United States, Germany

Explotab is a pharmaceutical excipient used as a disintegrant in solid dosage forms. It is designed to facilitate the breakup of tablets and capsules upon ingestion, aiding the release and subsequent absorption of the active pharmaceutical ingredient.

Automatically generated - may contain errors

Lab products found in correlation

Spelling variants of this product

Explotab® CLV (3 citations)

9 protocols using explotab

Fenofibrate Formulation Development

Check if the same lab product or an alternative is used in the 5 most similar protocols

Fenofibrate was kindly donated from JPI Co. (Riyadh, Saudi Arabia). Polyvinylpyrrolidone, Kollidon^® 12 and D-α-Tocopherol polyethylene glycol 1000 succinate, and Kolliphor^® TPGS were obtained as a gift sample from BASF Co. (Ludwigshafen, Germany). Microcrystalline cellulose and Avicel^® PH-102 were gained as a gift sample from DuPont Nutrition USA, Inc. (Wilmington, NC, USA). Lactose monohydrate and Granulac 200^® were obtained from Meggle (Wasserburg, Germany). Colloidal silicon dioxide and Aerosil 200^® were purchased from Evonik (Hanau-Wolfgang, Germany). Sodium stearyl fumarate, Pruv^® and sodium starch glycolate, and Explotab^® were obtained as a gift sample form JRS pharma (Rosenberg, Germany). Sodium dihydrogen phosphate dehydrate, disodium hydrogen phosphate dodecahydrate and sodium hydroxide were purchased from Merck (Darmstadt, Germany).

Fayed M.H., Alalaiwe A., Almalki Z.S, & Helal D.A. (2022). Design Space Approach for the Optimization of Green Fluidized Bed Granulation Process in the Granulation of a Poorly Water-Soluble Fenofibrate Using Design of Experiment. Pharmaceutics, 14(7), 1471.

+ Open protocol

+ Expand

Nebivolol Hydrochloride Formulation

Check if the same lab product or an alternative is used in the 5 most similar protocols

Nebivolol HCl (NEB) (2,2′-Azanediylbis(1-(6-fluorochroman-2-yl) ethanol) hydrochloride) was a kind gift from Menarini S.p.a. (L’Aquila, Italy). Beta-cyclodextrin (βCD) was from Sigma (St. Louis, MO, USA). Hydroxypropyl-βCD (HPβCD, average substitution degree 0.62) was kindly supplied by Roquette (Lestrem, France), and sulfobutylether-βCD (Dexolve^®) (SBEβCD, average substitution degree 6.5) was a kind gift from Cyclolab Ltd. (Budapest, Hungary). Randomly substituted methyl-βCD (RAMEB, average substitution degree 1.8) was from Wacker Chemie (München, Germany). Explotab^® (sodium starch glycolate) was from JRS Pharma (Rosenberg, Germany), and Mg stearate, polyvinylpyrrolidone (PVP) K90, mannitol and CaHPO₄ were from Sigma (St. Louis, MO, USA). All other chemicals and solvents were of analytical reagent grade.

Maestrelli F., Cirri M., Mennini N., Fiani S., Stoppacciaro B, & Mura P. (2024). Development of Oral Tablets of Nebivolol with Improved Dissolution Properties, Based on Its Combinations with Cyclodextrins. Pharmaceutics, 16(5), 633.

+ Open protocol

+ Expand

Dry Granulation and Tablet Formulation

Check if the same lab product or an alternative is used in the 5 most similar protocols

Example 9

After crystallization, polymorph forms of Formula I compound, may be formulated by dry granulation using a roller compactor, followed by a tableting operation. Additional ingredients in the tablets may include microcrystalline cellulose (Avicel PH, FMC BioPolymer), lactose (FastFlo, Foremost Farms USA), sodium starch glycolate (EXPLOTAB, JRS Pharma), or magnesium stearate (Hyqual, Macron Fine Chemicals).

US10851088B2. Polymorphs and solid forms of a pyrimidinylamino-pyrazole compound, and methods of production (2020-12-01). Denali Therapeutics Inc. [US]. Inventors: Travis Remarchuk [US], Anantha Sudhakar [US].

+ Open protocol

+ Expand

Formulation of Polymorph Forms

Check if the same lab product or an alternative is used in the 5 most similar protocols

Example 9

After crystallization, polymorph forms of Formula I compound, may be formulated by dry granulation using a roller compactor, followed by a tableting operation. Additional ingredients in the tablets may include microcrystalline cellulose (Avicel® PH, FMC BioPolymer), lactose (FastFlo®, Foremost Farms USA), sodium starch glycolate (EXPLOTAB®, JRS Pharma), or magnesium stearate (Hyqual®, Macron Fine Chemicals).

US10370361B2. Polymorphs and solid forms of a pyrimidinylamino-pyrazole compound, and methods of production (2019-08-06). Denali Therapeutics Inc. [US]. Inventors: Travis Remarchuk [US], Anantha Sudhakar [US].

+ Open protocol

+ Expand

Niclosamide ASD Granules Formulation

Check if the same lab product or an alternative is used in the 5 most similar protocols

The niclosamide ASD granules were admixed with sodium bicarbonate (Spectrum chemical, New Brunswick, NJ, USA) and sodium starch glycolate (Explotab^®, JRS Pharma, Patterson, NY, USA) in a 70/25/5 ratio. This mixture was filled into either Capsuline^® (HPMCP/HPMC) (Dania Beach, FL, USA) or Eudracap^TM (HPMC/Eudragit^® polymers) capsules, size 0. The Eudracaps were kindly donated by Evonik Corporation–North America (Piscataway, New Jersey, NJ, USA).

Jara M.O., Warnken Z.N., Sahakijpijarn S., Thakkar R., Kulkarni V.R., Christensen D.J., Koleng J.J, & Williams RO I.I.I. (2022). Oral Delivery of Niclosamide as an Amorphous Solid Dispersion That Generates Amorphous Nanoparticles during Dissolution. Pharmaceutics, 14(12), 2568.

+ Open protocol

+ Expand

Sustained-Release Metformin Pellet Formulation

Check if the same lab product or an alternative is used in the 5 most similar protocols

Pellets were fabricated with α-lactose monohydrate (Granulac 200^®, Meggle Pharma, Wasserburg am Inn, Germany), MCC (Ceolus^® PH-101, Asahi Kasei, Tokyo, Japan) or XPVP (Kollidon CL-M^®, BASF, Ludwigshafen, Germany), and metformin hydrochloride (MET; Granules India, Hyderabad, India). The sustained release layering material consisted of ethylcellulose (EC) dispersion (Aquacoat^® ECD, FMC Biopolymer, Philadelphia, PA, USA), triethyl citrate (Merck Schuchardt OHG, Hohenbrunn, Germany) as a plasticizer, and talc powder (Guangxi Longguang Talc Development Co., Ltd., Guilin, China) as an anti-adherent. MCC was also the tablet filler with sodium starch glycolate (Explotab^®, JRS Pharma, Pirna, Germany). Purified water was used as the dissolution and disintegration media.

Thio D.R., Heng P.W, & Chan L.W. (2022). MUPS Tableting—Comparison between Crospovidone and Microcrystalline Cellulose Core Pellets. Pharmaceutics, 14(12), 2812.

+ Open protocol

+ Expand

Antioxidant-Enriched Pharmaceutical Excipients

Check if the same lab product or an alternative is used in the 5 most similar protocols

The ABTS^•+ (2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (purity 98%), Trolox (6-hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid), 97% absolute ethanol, D-mannitol, trifluoracetic acid (TFA, 99%), microcrystalline cellulose (MCC), Arabic gum, and sodium chloroacetate (SCA, 98%) were obtained from Sigma Aldrich (Saint Louis, MO, USA). High amylose corn starch (Hylon VII) was kindly provided by Ingredion (Westchester, IN, USA). Croscarmellose sodium (Solutab^®, CMC, 98%) was purchased from Blanver (São Paulo, SP, Brazil). Explotab^® and Prosolv^® were obtained from JRS pharma (Patterson, NY, USA) and polyvinylpyrrolidone (PVP) from International Specialty Products (Wayne, WA, USA). The other chemicals were reagent grade.

De Sousa Sabino L.B., Copes F., Saulais S., De Brito E.S., Da Silva Júnior I.J., Le T.C., Mateescu M.A, & Mantovani D. (2022). Anthocyanins Formulated with Carboxymethyl Starch for Gastric and Intestinal Delivery. Molecules, 27(21), 7271.

+ Open protocol

+ Expand

Formulation of Polymorph Compounds

Check if the same lab product or an alternative is used in the 5 most similar protocols

Example 9

After crystallization, polymorph forms of Formula I compound, may be formulated by dry granulation using a roller compactor, followed by a tableting operation. Additional ingredients in the tablets may include microcrystalline cellulose (Avicel® PH, FMC BioPolymer), lactose (FastFlo®, Foremost Farms USA), sodium starch glycolate (EXPLOTAB®, JRS Pharma), or magnesium stearate (Hyqual®, Macron Fine Chemicals).

US11427571B2. Polymorphs and solid forms of a pyrimidinylamino-pyrazole compound, and methods of production (2022-08-30). DENALI THERAPEUTICS INC. [US]. Inventors: Travis Remarchuk [US], Anantha Sudhakar [US].

+ Open protocol

+ Expand

Formulation and Characterization of Nimodipine Cyclodextrin Complexes

Check if the same lab product or an alternative is used in the 5 most similar protocols

Nimodipine (Nim) was purchased from Fagron, Greece; and hydroxypropyl-β-cyclodextrin (HP-β-CD) and methyl-β-cyclodextrin (Me-β-CD) were provided from the Global Holding Group Co., Ltd., (Ningbo, China). All used chemicals and solvents were of analytical reagent grade.
F-MELT^® was purchased from Fuji Chemical Industries Co., Ltd., Toyama, Japan; Disintequik™ ODT was purchased from Kerry Inc., Beloit, WI, USA; and PROSOLV^® SMCC HD 90 and EXPLOTAB^® were provided by JRS PHARMA GmbH & Co. KG, Rosenberg, Germany. LIGAMED^® MF-2-V, used in the study, was produced by Peter Graven NV, Venlo, Limburg, The Netherlands.
A Mettler Toledo AT261 balance (with 0.01 mg sensitivity) was used for weighing the raw materials.

Novac M., Musuc A.M., Ozon E.A., Sarbu I., Mitu M.A., Rusu A., Gheorghe D., Petrescu S., Atkinson I, & Lupuliasa D. (2022). Manufacturing and Assessing the New Orally Disintegrating Tablets, Containing Nimodipine-hydroxypropyl-β-cyclodextrin and Nimodipine-methyl-β-cyclodextrin Inclusion Complexes. Molecules, 27(6), 2012.

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!