For each patient CBCT, planning CT and repeat CT images were used. CBCT images were acquired with an IBA Proteus Plus (IBA, Belgium) and reconstructed with the clinically used protocol. Repeat 4D‐CT and planning 4D‐CT scans were acquired on a Siemens
SOMATOM Confidence (Siemens Healthineers, Germany) and on a Siemens
SOMATOM Definition AS scanner, respectively, using the same imaging protocol. For treatment planning and dose calculation, average 4DCTs were generated from the 10 breathing phases of pCTs and rCTs. More detailed imaging and reconstruction parameters for CBCT, rCT, and pCT are listed in the Supporting Information (Table
S2).
Repeat CT scans were acquired on the same day as the CBCT, used for training of the DCNN and selected as reference for image quality and dosimetric evaluation. There was a time difference of a few weeks between the pCT acquisition, used within the patient specific correction workflow, and the rCT/CBCT acquisition. For all patients, the first available rCT‐CBCT pair (acquired in the first week of treatment) was chosen.
Thummerer A., Seller Oria C., Zaffino P., Meijers A., Guterres Marmitt G., Wijsman R., Seco J., Langendijk J.A., Knopf A., Spadea M.F, & Both S. (2021). Clinical suitability of deep learning based synthetic CTs for adaptive proton therapy of lung cancer. Medical Physics, 48(12), 7673-7684.