Oxymetazoline

4-Hydroxy guanabenz hydrochloride (4-OH-Guanabenz), full name: 2-[(2,6-Dichloro-4-hydroxyphenyl)methylene]hydrazinecarboximidamide Hydrochloride (Fig. 1) was synthesized in the Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland.Fig. 1

Chemical structure of 4-OH-Guanabenz. The structure was created using ChemDraw 20.1 software

Heparin was delivered by Polfa Warszawa S.A. (Warsaw, Poland), while thiopental sodium and ketoprofen were from Sandoz GmbH (Austria), ketamine and xylasine from Biowet Puławy (Poland), and cefuroxime from Polfarma S.A. (Poland), brimonidine, oxymetazoline, and yohimbine from Sigma-Aldrich (Germany).
1-(3-Chlorophenyl)piperazine (mCPP) was synthesized in the Department of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland.
Chemicals, such as HPLC grade acetonitrile, methanol, and nebivolol, were supplied by Merck (Darmstadt, Germany). Formic acid was obtained from Fluka (Buchs, Switzerland). Potassium dihydrogen phosphate, disodium hydrogen phosphate, and sodium chloride were purchased from J. T. Baker (Phillipsburg, PA, USA). Purified water (18.2 MΩ) was delivered by a Milli-Q water system (Millipore, Billerica, MA, USA).

Guanfacine, oxymetazoline, brimonidine, clonidine (Sigma-Aldrich, Germany), yohimbine (Tocris, Bristol, UK), heparin (Polfa Warszawa S.A., Warsaw, Poland), and thiopental (Sandoz International, France).

Esomeprazole, Pargyline, Leflunomide, Clofibrate, Ciprofloxacin, Ketorolac, Paroxetine, Dobutamine, Tranilast, Loperamide, Xylazine, Capsaicin, Papaverine, Oxymetazoline, Dexamethasone, Docetaxel, Topotecan, Paclitaxel were purchased from Sigma. Almotriptan Malate and Sirolimus were purchased from Selleckchem, Gefitinib from Invivogen, Cefprozil Monohydrate from Abcam and Imexon from MicroSource Discovery Systems Inc.; ATP, Apyrase, Suramin and Mefloquine were purchased from Sigma; Latrunculin B was purchased from Abcam.