Log In Sign up
The largest database of trusted experimental protocols

Simcyp version 15

Manufactured by Certara
Visit Supplier

Simcyp Version 15 is a physiologically-based pharmacokinetic (PBPK) modeling and simulation platform developed by Certara. It is designed to predict the pharmacokinetics and pharmacodynamics of drugs in virtual populations. The platform incorporates a comprehensive database of human physiological and biochemical parameters, as well as drug-specific parameters, to enable the simulation of drug absorption, distribution, metabolism, and elimination.

Automatically generated - may contain errors

Lab products found in correlation

Spelling variants of this product

Simcyp (8 citations)

2 protocols using simcyp version 15

1

Pediatric PBPK Modeling of CYP2C19 Maturation

Check if the same lab product or an alternative is used in the 5 most similar protocols
The exploration of CYP2C19 maturation followed a learn‐confirm‐refine strategy for each PBPK model. The workflow for pantoprazole and esomeprazole PBPK models used for pediatrics is described in Figure1.15, 16 All the PBPK models were developed in Simcyp version 15 (Certara).
Duan P., Wu F., Moore J.N., Fisher J., Crentsil V., Gonzalez D., Zhang L., Burckart G.J, & Wang J. (2018). Assessing CYP2C19 Ontogeny in Neonates and Infants Using Physiologically Based Pharmacokinetic Models: Impact of Enzyme Maturation Versus Inhibition. CPT: Pharmacometrics & Systems Pharmacology, 8(3), 158-166.
+ Open protocol
+ Expand
2

Simcyp PBPK Model for Pravastatin

Check if the same lab product or an alternative is used in the 5 most similar protocols
Simcyp, version 15 (Certara, Princeton, NJ) PBPK model for pravastatin was used in this investigation. The input parameters for pravastatin model are summarized in Table1. Information that has been previously disclosed in the Simcyp compound profile of pravastatin is indicated in Table1. The basic model structure and details of model modification are described below.
Mao J., Doshi U., Wright M., Hop C.E., Li A.P, & Chen Y. (2018). Prediction of the Pharmacokinetics of Pravastatin as an OATP Substrate Using Plateable Human Hepatocytes With Human Plasma Data and PBPK Modeling. CPT: Pharmacometrics & Systems Pharmacology, 7(4), 251-258.
+ Open protocol
+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required

Sign up now

Revolutionizing how scientists
search and build protocols!