Sulisobenzone

Dimethyl sulfoxide (DMSO, 49), p-nitrosodimethylaniline, imidazole, nitroblue tetrazolium (NBT), quinine HCl (1), 4-methyl-7-ethoxycoumarin (3), 7-methoxycoumarin (5), 8-methoxypsoralen (6), acridine (7), diclofenac Na (11), hexachlorophene (16), indomethacin (19), ketoprofen ( 21), methyl β-naphthyl ketone (22), piroxicam (29), promethazine HCl (31), sulfanilamide (34), tetracycline HCl (35), 1,3-butylene glycol (47), 2-propanol (48), ethanol (50), and glycerin (51) were obtained from Fujifilm-Wako Pure Chemical Industries. Sulisobenzone (2), bithionol (9), doxycycline HCl (12), enoxacin (13), furosemide ( 14), glibenclamide (15), hydrochlorothiazide (16), ibuprofen (18), isoniazid (20), mequitazine (24), nalidixic acid (25), octyl dimethyl PABA (26), ofloxacin ( 27), omadine Na (28), prochlorperazine maleate (30), pyridoxine HCl (32), sparfloxacin (33), lactic acid (52), and penicillin G (54) were purchased from Sigma-Aldrich Japan. Benzophenone (8), lauric acid (53), and propylene glycol (55) were obtained from Junsei Chemical Co. (Tokyo, Japan), and 6-methylcoumarin (4) was purchased from Nacalai Tesque. Chlorpromazine HCl (10) and methyl-N-methylanthranilate (23) were purchased from Tokyo Chemical Industry (Tokyo, Japan).

Twenty phototoxic chemicals and 10 non-phototoxic chemicals were evaluated, including 6 drugs, 8 antimicrobials, 6 fragrances, 6 UV absorbers, and 4 other chemicals. Amiodarone HCl (1), anthracene (7), chlorpromazine HCl (9), 5-methoxypsoralen (15), 8-methox-ypsoralen (16), 6-methylcoumarin (17), ofloxacin (18) , hexachlorophene (21), ethylhexyl dimethyl p-aminobenzoate (23), chlorhexidine dihydrochloride (24), sodium lauryl sulfate (27), p-aminobenzoic acid (28), sulisobenzone (29), and lactic acid (30) were purchased from Sigma-Aldrich Japan (Tokyo, Japan). Rose bengal (2), bithionol (4), 3,3'4,5 tetrachlorosalicylanilide (5), fenofibrate (6), benzophenone (11), ketoprofen (13), methyl n-methylantranilate ( 14), and norfloxacin (19) were purchased from Wako Pure Chemical Industries (Osaka, Japan). 3,4',5-Tribromosalicylanilide (3), musk ambrette (8), promethazine (10), musk xylene (12), protoporphyrin IX, disodium (20), 2-octyl salicylate ( 22), 2-octyl methacrylate (25), and penicillin G (26) were purchased from Tokyo Chemical Industry (Tokyo, Japan).